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  1. 1.   Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids
  2. Dexheimer,Tom; Davoudi,Zahra; Coussens,Nathan; Silvers,Thomas; Morris, Joel; Takebe, Naoko; Said, Rabih; Moscow, Jeffrey A; Doroshow, James H; Teicher, Beverly A
  3. SLAS Discovery : advancing life sciences R & D. 2025, Feb 23; 100222.
  1. 2.   A randomised, placebo-controlled, phase III trial of leniolisib in activated phosphoinositide 3-kinase delta (PI3Kd) syndrome (APDS): Adolescent and adult subgroup analysis
  2. Rao, V Koneti; Šedivá, Anna; Dalm, Virgil A S H; Plebani, Alessandro; Schuetz, Catharina; Shcherbina, Anna; Trizzino, Antonino; Zharankova, Yulia; Orpia, Alanvin; Kulm,Elaine; Webster, Sharon; Körholz, Julia; Lougaris, Vassilios; Rodina, Yulia; Conlon, Niall; Coulter, Tanya; Bradt, Jason; Relan, Anurag; Uzel, Gulbu
  3. Clinical Immunology (Orlando, Fla.). 2024, Nov 17; 110400.
  1. 3.   Improved Production of Class I Phosphatidylinositol 4,5-bisphosphate 3-kinase
  2. Messing,Simon; Widmeyer, Stephanie R T; Denson,John-Paul; Mehalko,Jennifer; Wall,Vanessa; Drew,Matt; Snead,Kelly; Hong,Min; Grose,Carissa; Esposito,Dom; Gillette,Bill
  3. Protein Expression and Purification. 2024, Aug 20; 106582.
  1. 4.   Interim Analysis: Open-Label Extension Study of Leniolisib for Patients with APDS
  2. Rao, V Koneti; Kulm,Elaine; Šedivá, Anna; Plebani, Alessandro; Schuetz, Catharina; Shcherbina, Anna; Dalm, Virgil A; Trizzino, Antonino; Zharankova, Yulia; Webster, Sharon; Orpia, Alanvin; Körholz, Julia; Lougaris, Vassilios; Rodina, Yulia; Radford, Kath; Bradt, Jason; Relan, Anurag; Holland, Steven M; Lenardo, Michael J; Uzel, Gulbu
  3. The Journal of Allergy and clinical immunology.. 2023, Oct 03;
  1. 5.   Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
  2. Pahwa, Roma; Dubhashi, Janhavi; Singh, Anand; Jailwala, Parthav; Lobanov,Alexei; Thomas, Craig J; Ceribelli, Michele; Wilson, Kelli; Ricketts, Christopher J; Vocke, Cathy D; Wells, Catherine; Bottaro, Donald P; Linehan, W Marston; Neckers, Len; Srinivasan, Ramaprasad
  3. Journal of Experimental & Clinical Cancer Research : CR. 2022, Jun 27; 41(1): 208.
  1. 6.   Drugging multiple same-allele driver mutations in cancer
  2. Nussinov,Ruth; Zhang,Mingzhen; Maloney,Ryan; Jang, Hyunbum
  3. Expert Opinion on Drug Discovery. 2021, Aug; 16(8): 823-828.
  1. 7.   The Structural Basis of Akt PH Domain Interaction with Calmodulin
  2. Weako,Jackson; Jang, Hyunbum; Keskin, Ozlem; Nussinov,Ruth; Gursoy, Attila
  3. Biophysical Journal. 2021, May 18; 120(10): 1994-2008.
  1. 8.   New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases
  2. Bensen, Ryan; Brognard,John
  3. International Journal of Molecular Sciences. 2021, Mar; 22(6):
  1. 9.   Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases
  2. Zhang,Mingzhen; Jang,Hyunbum; Nussinov,Ruth
  3. Journal of molecular biology. 2020, NOV 6; 432(22): 5849-5859.
  1. 10.   PIK3Cd expression by fibroblasts promotes triple-negative breast cancer progression
  2. Gagliano, Teresa; Shah, Kalpit; Gargani, Sofia; Lao, Liyan; Alsaleem, Mansour; Chen, Jianing; Ntafis, Vasileios; Huang, Penghan; Ditsiou, Angeliki; Vella, Viviana; Yadav, Kritika; Bienkowska, Kamila; Bresciani, Giulia; Kang, Kai; Li, Leping; Carter, Philip; Benstead-Hume, Graeme; O'Hanlon,Tim; Dean,Michael; Pearl, Frances Mg; Lee, Soo Chin; Rakha, Emad A; Green, Andrew R; Kontoyiannis, Dimitris L; Song, Erwei; Stebbing, Justin; Giamas, Georgios
  3. The Journal of clinical investigation. 2020, JUN 1; 130(6): 3188-3204.
  1. 11.   Ras assemblies and signaling at the membrane
  2. Nussinov,Ruth; Tsai,Chung-Jung; Jang,Hyunbum
  3. Current opinion in structural biology. 2020, JUN; 62: 140-148.
  1. 12.   BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-kappa B and PI3K/AKT Signaling During Infection
  2. Miao, Yuhui; Jiang, Ming; Qi, Lu; Yang,De; Xiao, Weihua; Fang, Fang
  3. FRONTIERS IN IMMUNOLOGY. 2020, Feb 18; 11
  1. 13.   Ca2+-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1
  2. Zhang,Mingzhen; Li, Zhigang; Jang,Hyunbum; Hedman, Andrew C.; Sacks, David B.; Nussinov,Ruth
  3. BIOCHEMISTRY. 2019, Dec 10; 58(49): 4903-4911.
  1. 14.   The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin
  2. Jang,Hyunbum; Banerjee, Avik; Marcus, Kendra; Makowski, Lee; Mattos, Carla; Gaponenko, Vadim; Nussinov,Ruth
  3. Structure (London, England : 1993). 2019, Nov 5; 27(11): 1647-1659.e4.
  1. 15.   Calmodulin (CaM) Activates PI3K alpha by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85 alpha
  2. Zhang,Mingzhen; Li, Zhigang; Wang, Guanqiao; Jang,Hyunbum; Sacks, David B.; Zhang, Jian; Gaponenko, Vadim; Nussinov,Ruth
  3. JOURNAL OF PHYSICAL CHEMISTRY B. 2018, Dec 13; 122(49): 11137-11146.
  1. 16.   Esophageal squamous cell carcinoma transcriptome reveals the effect of FOXM1 on patient outcome through novel PIK3R3 mediated activation of PI3K signaling pathway
  2. Nicolau-Neto, Pedro; Da Costa, Nathalia Meireles; de Souza Santos, Paulo Thiago; Gonzaga, Isabela Martins; Ferreira, Maria Aparecida; Guaraldi, Simone; Moreira, Miguel Angelo; Seuánez, Hector N; Brewer, Lilian; Bergmann, Anke; Boroni, Mariana; Mencalha, Andre Luiz; Kruel, Cleber Dario Pinto; Lima, Sheila Coelho Soares; Esposito, Dom; Simão, Tatiana Almeida; Pinto, Luis Felipe Ribeiro
  3. Oncotarget. 2018, Mar 30; 9(24): 16634-16647.
  1. 17.   Flexible-Body Motions of Calmodulin and the Farnesylated Hypervariable Region Yield a High-Affinity Interaction Enabling K-Ras4B Membrane Extraction.
  2. Jang, Hyunbum; Banerjee, Avik; Chavan, Tanmay; Gaponenko, Vadim; Nussinov, Ruth
  3. The Journal of biological chemistry. 2017, Jul 28; 292(30): 12544-12559.
  1. 18.   A Computational Tool for Quantitative Analysis of Vascular Networks
  2. Zudaire, E.; Gambardella, L.; Kurcz, C.; Vermeren, S.
  3. Plos One. 2011, Nov; 6(11): 12.
  1. 19.   LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?
  2. Orr, S. J.; McVicar, D. W.
  3. Journal of Leukocyte Biology. 2011, Jan; 89(1): 11-19.
  1. 20.   In vivo expression of signaling proteins in reconstituted NK cells
  2. Orr, S. J.; Quigley, L.; McVicar, D. W.
  3. Journal of Immunological Methods. 2009 340(2): 158-163.
  1. 21.   The Immunostimulative Effect and Mechanisms of a Novel Mouse Anti-Human PD-1 Monoclonal Antibody on Jurkat Lymphocytic Cells Cocultured with Hepatoma Cells
  2. Li, Ziwei; Li, Bin; Li, Li; Wang, Guanying; Li, Yuanyuan; Fu, Ruoqiu; Ming, Yue; Ni, Rui; Wang,Jiming; Ye, George; Chen, Jianhong
  3. OncoTargets and Therapy. 2020 13: 12225-12241.
  1. 22.   High-Throughput Cell-Based Screening of Small Molecule KRAS Signaling Inhibitors Using a Homogeneous Time-Resolved Fluorescence (HTRF) Assay
  2. Smith,Brian; Rigby,Megan; Ma,Roger; Maciag,Anna
  3. Methods in Molecular Biology (Clifton, N.J.). 2024 2797: 271-285.
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