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  1. 1.   HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCe Activation
  2. Mancardi, Daniele; Pagliaro, Pasquale; Ridnour,Lisa; Tocchetti, Carlo G; Miranda, Katrina; Juhaszova, Magdalena; Sollott, Steven J; Wink,David; Paolocci, Nazareno
  3. Antioxidants (Basel, Switzerland). 2022, Feb 14; 11(2):
  1. 2.   New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases
  2. Bensen, Ryan; Brognard,John
  3. International Journal of Molecular Sciences. 2021, Mar; 22(6):
  1. 3.   Orange is the new black: Kinases are the new master regulators of tumor suppression
  2. An,Elvira; Brognard,John
  3. IUBMB LIFE. 2019, JUN; 71(6): 738-748.
  1. 4.   Protein kinase Ca gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation
  2. Callender, Julia A; Yang, Yimin; Lordén, Gema; Stephenson, Natalie L; Jones, Alexander C; Brognard, John; Newton, Alexandra C
  3. Proceedings of the National Academy of Sciences of the United States of America. 2018, Jun 12; 115(24): E5497-E5505.
  1. 5.   Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.
  2. Czikora, Agnes; Lundberg, Daniel J; Abramovitz, Adelle; Lewin, Nancy E; Kedei, Noemi; Peach, Megan L; Zhou, Xiaoling; Merritt, Raymond C; Craft, Elizabeth A; Braun, Derek C; Blumberg, Peter M
  3. The Journal of biological chemistry. 2016, May 20; 291(21): 11133-47.
  1. 6.   Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells
  2. Hong, S. H.; Osborne, T.; Ren, L.; Briggs, J.; Mazcko, C.; Burkett, S. S.; Khanna, C.
  3. Veterinary and Comparative Oncology. 2011, Sep; 9(3): 207-218.
  1. 7.   Protein Kinase C zeta Mediates mu-Opioid Receptor-induced Cross-desensitization of Chemokine Receptor CCR5
  2. Song, C. C.; Rahim, R. T.; Davey, P. C.; Bednar, F.; Bardi, G.; Zhang, L.; Zhang, N.; Oppenheim, J. J.; Rogers, T. J.
  3. Journal of Biological Chemistry. 2011, Jun; 286(23): 20354-20365.
  1. 8.   Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities
  2. Raifman, O.; Kolusheva, S.; Comin, M. J.; Kedei, N.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.; Jelinek, R.
  3. Febs Journal. 2010, Jan; 277(1): 233-243.
  1. 9.   Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta
  2. Choi, S. H.; Czifra, G.; Kedei, N.; Lewin, N. E.; Lazar, J.; Pu, Y. M.; Marquez, V. E.; Blumberg, P. M.
  3. Journal of Biological Chemistry. 2008 283(16): 10543-10549.
  1. 10.   Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
  2. Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; El Kazzouli, S.; Chung, J. U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5198-5220.
  1. 11.   Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms
  2. Pu, Y. M.; Peach, M. L.; Garfield, S. H.; Wincovitch, S.; Marquez, V. E.; Blumberg, P. M.
  3. Journal of Biological Chemistry. 2006, Nov; 281(44): 33773-33788.
  1. 12.   Actin is the primary cellular receptor of bistramide A
  2. Statsuk, A. V.; Bai, R. L.; Baryza, J. L.; Verma, V. A.; Hamel, E.; Wender, P. A.; Kozmin, S. A.
  3. Nature Chemical Biology. 2005, DEC; 1(7): 383-388.
  1. 13.   Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE(2) and TGF-beta(1)
  2. Ha, C. T.; Waterhouse, R.; Wessells, J.; Wu, J. A.; Dveksler, G. S.
  3. Journal of Leukocyte Biology. 2005, JUN; 77(6): 948-957.
  1. 14.   Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKC delta-dependent increase in p27(Kip1) and decrease in retinoblastoma protein (pRb) phosphorylation
  2. Vucenik, I.; Ramakrishna, G.; Tantivejkul, K.; Anderson, L. M.; Ramljak, D.
  3. Breast Cancer Research and Treatment. 2005, MAY; 91(1): 35-45.
  1. 15.   PKC delta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
  2. Jelacic, T.; Linnekin, D.
  3. Blood. 2005, MAR 1; 105(5): 1923-1929.
  1. 16.   Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells
  2. Sun, R. H.; Gao, P.; Chen, L.; Ma, D. L.; Wang, J. M.; Oppenheim, J. J.; Zhang, N.
  3. Cancer Research. 2005, FEB 15; 65(4): 1433-1441.
  1. 17.   Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo
  2. Cataisson, C.; Pearson, A. J.; Torgerson, S.; Nedospasov, S. A.; Yuspa, S. H.
  3. Journal of Immunology. 2005, FEB 1; 174(3): 1686-1692.
  1. 18.   A proinflarnmatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
  2. Zhang, N.; Inan, S.; Cowan, A.; Sun, R. H.; Wang, J. M.; Rogers, T. J.; Caterina, M.; Oppenheim, J. J.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005 102(12): 4536-4541.
  1. 19.   Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, SEP 23; 47(20): 4858-4864.
  1. 20.   The discovery of protein kinase C (PK-C) isozyme: Specific ligands driven by a solid-phase combinatorial synthesis of diacylglycerol-lactones (DAG-lactones)
  2. Duan, D. H.; Peach, M. L.; Lai, C. C.; Lewin, N. E.; Kelley, J. A.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 177-MEDI, Abstract U939-177-MEDI, Abstract U939.
  1. 21.   Hydrophobic ligand-protein interactions vs. ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Sigano, D. M.; Tamamura, H.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 229-MEDI, Abstract U949-229-MEDI, Abstract U949.
  1. 22.   New design approaches aimed at targeting atypical PKC isoform zeta with diacylglycerol-lactones (DAG-lactones)
  2. Kang, J. H.; Peach, M. L.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(031-MEDI, Part 2): U10-U10.
  1. 23.   Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands
  2. Lee, J.; Kim, S. Y.; Kang, J. H.; Acs, G.; Acs, P.; Blumberg, P. M.; Marquez, V. E.
  3. European Journal of Medicinal Chemistry. 2004 39(1): 69-77.
  1. 24.   Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine
  2. Pettit, G. R.; Hoffmann, H.; Herald, D. L.; McNulty, J.; Murphy, A.; Higgs, K. C.; Hamel, E.; Lewin, N. E.; Pearce, L. V.; Blumberg, P. M.; Pettit, R. K.; Knight, J. C.
  3. Journal of Organic Chemistry. 2004 69(7): 2251-2256.
  1. 25.   Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(3): 644-655.
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