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  1. 1.   Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
  2. Cecchini, Michael; Pilat, Mary Jo; Uboha, Nataliya; Azad, Nilofer S; Cho, May; Davis, Elizabeth J; Ahnert, Jordi Rodon; Tinoco, Gabriel; Shapiro, Geoffrey I; Khagi, Simon; Powers, Benjamin; Spencer, Kristen; Groisberg, Roman; Drappatz, Jan; Chen, Li; Das,Bishu; Bao, Xun; Li, Jing; Narayan, Azeet; Vu, Dennis; Patel, Abhijit; Niger, Monica; Doroshow, Deborah; Durecki, Diane; Boerner, Scott A; Bindra, Ranjit; Ivy, Percy; Shyr, Derek; Shyr, Yu; LoRusso, Patricia M
  3. Cancer. 2025, Feb 15; 131(4): e35755.
  1. 2.   Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers
  2. Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Tetrahedron. 2025, Feb 01; 171
  1. 3.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 4.   Purification of Circular RNAs Using Poly(A) Tailing Followed by RNase R Digestion
  2. Xiao, Mei-Sheng; Wilusz, Jeremy E
  3. Methods in Molecular Biology (Clifton, N.J.). 2024 2765: 3-19.
  1. 5.   Quantitation of Active Pharmaceutical Ingredients in Polymeric Drug Products Using Elemental Analysis
  2. Xu,Jie; Hu, Yingwen; Clogston,Jeffrey
  3. Methods in Molecular Biology (Clifton, N.J.). 2024 2789: 35-43.
  1. 6.   Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
  2. Ren, Wen; Deng, Yuling; Ward, Jacob D; Vairin, Rebecca; Bai,Ruoli; Wanniarachchi, Hashini I; Hamal, Khagendra B; Tankoano, Pouguiniseli E; Tamminga, Caleb S; Bueno, Lorena M A; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. European Journal of Medicinal Chemistry. 2023, Sep 06; 263: 115794.
  1. 7.   Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
  2. Hawash, Mohammed; Ergun, Sezen Guntekin; Kahraman, Deniz Cansen; Olgac, Abdurrahman; Hamel,Ernest; Cetin-Atalay, Rengul; Baytas, Sultan Nacak
  3. Journal of Molecular Structure. 2023, Aug 05; 1285
  1. 8.   Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues
  2. Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai,Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2023, Jun 29; 92: 117400.
  1. 9.   Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG
  2. Yakhnin,Alex; Bubunenko,Mikhail; Mandell, Zachary F; Lubkowska,Lucyna; Husher, Sara; Babitzke, Paul; Kashlev,Mikhail
  3. Proceedings of the National Academy of Sciences of the United States of America. 2023, Jun 13; 120(24): e2221114120.
  1. 10.   Plasma Stability and Plasma Metabolite Concentration-Time Profiles of Oligo(Lactic Acid)8-Paclitaxel Prodrug Loaded Polymeric Micelles
  2. Repp, Lauren; Skoczen,Sarah; Rasoulianboroujeni, Morteza; Stern,Steve; Kwon, Glen S
  3. The AAPS Journal. 2023, Apr 11; 25(3): 39.
  1. 11.   Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design
  2. Shaw,Gary; Fan,Lixin; Cherry,Scott; Shi,Genbin; Tropea, Joseph E; Ji,Xinhua
  3. Current Research in Structural Biology. 2023, Jan 30; 5: 100095.
  1. 12.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 13.   Homologs of the Escherichia coli F Element Protein TraR, Including Phage Lambda Orf73, Directly Reprogram Host Transcription
  2. Gopalkrishnan, Saumya; Ross, Wilma; Akbari, Madeline S; Li, Xintian; Haycocks, James R J; Grainger, David C; Court,Don; Gourse, Richard L
  3. mBio. 2022, May 18; e0095222.
  1. 14.   Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis
  2. Jayasinghe, Oshadhi T; Mandell, Zachary F; Yakhnin,Alex; Kashlev,Mikhail; Babitzke, Paul
  3. Journal of Bacteriology. 2022, Mar 08; e0053421.
  1. 15.   MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome"
  2. Das, Subhendu K.; Kuzin, Vladislav; Cameron, Donald P.; Sanford, Suzanne; Jha, Rajiv Kumar; Nie, Zuqin; Rosello, Marta Trullols; Holewinski,Ronald; Andresson,Thorkell; Wisniewski, Jan; Natsume, Toyoaki; Price, David H.; Lewis, Brian A.; Kouzine, Fedor; Levens, David; Baranello, Laura
  3. Molecular Cell. 2022, Jan 6; 82(1): 140-158. e12.
  1. 16.   Bioequivalence assessment of high-capacity polymeric micelle nanoformulation of paclitaxel and Abraxane (R) in rodent and non-human primate models using a stable isotope tracer assay
  2. Hwang, Duhyeong; Vinod, Natasha; Skoczen,Sarah; Ramsey, Jacob D.; Snapp,Kelsie; Montgomery, Stephanie A.; Wang, Mengzhe; Lim, Chaemin; Frank, Jonathan E.; Sokolsky-Papkov, Marina; Li, Zibo; Yuan, Hong; Kabanov, Alexander; Stern,Steve
  3. Biomaterials . 2021, Nov; 278
  1. 17.   Iterative epigenomic analyses in the same single cell
  2. Ohnuki, Hidetaka; Venzon, David J.; Lobanov,Alexei; Tosato, Giovanna
  3. Genome Research. 2021, Oct; 31(11): 1819-1830.
  1. 18.   SARS-CoV-2: from its discovery to genome structure, transcription, and replication
  2. Castro Brant,Ayslan; Tian, Wei; Majerciak,Vladimir; Yang, Wei; Zheng,Zhi-Ming
  3. Cell & bioscience. 2021, Jul 19; 11(1):
  1. 19.   The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences
  2. Newman, Jane D.; Russell, Meghan M.; Fan,Lixin; Wang,Yun-Xing; Gonzalez-Gutierrez, Giovanni; van Kessel, Julia C.
  3. Nucleic acids research. 2021, Jun 4; 49(10): 5967-5984.
  1. 20.   Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
  2. Nance,Kellie; Meier,Jordan
  3. ACS central science. 2021, May 26; 7(5): 748-756.
  1. 21.   Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes
  2. Raskatov, Jevgenij A.; Schneider,Joel; Nilsson, Bradley L.
  3. Accounts of chemical research. 2021, MAY 18; 54: 2488-2501.
  1. 22.   Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors
  2. Takebe, Naoko; Naqash, Abdul Rafeh; Coyne, Geraldine O'Sullivan; Kummar, Shivaani; Do, Khanh; Bruns, Ashley; Juwara,Lamin; Zlott, Jennifer; Rubinstein, Larry; Piekarz, Richard; Sharon, Elad; Streicher, Howard; Mittra, Arjun; Miller, Sarah B.; Ji,Jay; Wilsker,Deborah; Kinders,Robert; Parchment,Ralph; Chen,Li; Chang,Ting-Chia; Das,Biswajit; Mugundu, Ganesh; Doroshow, James H.; Chen, Alice P.
  3. CLINICAL CANCER RESEARCH. 2021, Apr 16; 27(14): 3834-3844.
  1. 23.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 24.   Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors
  2. Spano, Virginia; Barreca, Marilia; Rocca, Roberta; Bortolozzi, Roberta; Bai, Ruoli; Carbone, Anna; Raimondi, Maria Valeria; Piccionello, Antonio Palumbo; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2021, Feb 15; 212
  1. 25.   The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity
  2. Xiang, Weiguo; Quadery, Tasdique M; Hamel,Ernest; Luckett-Chastain, Lerin R; Ihnat, Michael A; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & medicinal chemistry. 2021, Jan 1; 29: 115887.
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