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  1. 1.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 2.   Diazeniumdiolated carbamates: A novel class of nitric oxide donors
  2. Nandurdikar, R. S.; Maciag, A. E.; Cao, Z.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2012, Mar; 20(6): 2025-2029.
  1. 3.   Nitrogen-bound diazeniumdiolated amidines
  2. Biswas, D.; Deschamps, J. R.; Keefer, L. K.; Hrabie, J. A.
  3. Chemical Communications. 2010, Aug 21; 46(31): 5799-5801.
  1. 4.   Soft alkyl ether prodrugs of a model phenolic drug: the effect of incorporation of ethyleneoxy groups on transdermal delivery
  2. Thomas, J. D.; Majumdar, S.; Sloan, K. B.
  3. Molecules (Basel, Switzerland). 2009 14(10): 4231-45.
  1. 5.   Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound
  2. Nandurdikar, R. S.; Maciag, A. E.; Citro, M. L.; Shami, P. J.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(10): 2760-2762.
  1. 6.   Aryl Bis(diazeniumdiolates): Potent Inducers of S-Glutathionylation of Cellular Proteins and Their in Vitro Antiproliferative Activities
  2. Andrei, D.; Maciag, A. E.; Chakrapani, H.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Journal of Medicinal Chemistry. 2008 51(24): 7944-7952.
  1. 7.   Benzoylphenylurea sulfur analogues with potent antitumor activity
  2. Hallur, G.; Jimeno, A.; Dalrymple, S.; Zhu, T.; Jung, M. K.; Hidaleo, M.; Isaacs, J. T.; Sukumar, S.; Hamel, E.; Khan, S. R.
  3. Journal of Medicinal Chemistry. 2006, Apr; 49(7): 2357-2360.
  1. 8.   Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug
  2. Waterhouse, D. J.; Saavedra, J. E.; Davies, K. M.; Citro, M. L.; Xu, X.; Powell, D. A.; Grimes, G. J.; Potti, G. K.; Keefer, L. K.
  3. Journal of Pharmaceutical Sciences. 2006, JAN; 95(1): 108-115.
  1. 9.   Dolastatin 11 conformations, analogues and pharmacophore
  2. Ali, M. A.; Bates, R. B.; Crane, Z. D.; Dicus, C. W.; Gramme, M. R.; Hamel, E.; Marcischak, J.; Martinez, D. S.; McClure, K. J.; Nakkiew, P.; Pettit, G. R.; Stessman, C. C.; Sufi, B. A.; Yarick, G. V.
  3. Bioorganic & Medicinal Chemistry. 2005, JUL 1; 13(13): 4138-4152.
  1. 10.   Fluorinated 2-(4-amino-3-methylphenyl) benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells
  2. Brantley, E.; Trapani, V.; Alley, M. C.; Hose, C. D.; Bradshaw, T. D.; Stevens, M. F. G.; Sausville, E. A.; Stinson, S. F.
  3. Drug Metabolism and Disposition. 2004, DEC; 32(12): 1392-1401.
  1. 11.   The experimental antitumor agents Phortress and Doxorubicin are equiactive against human-derived breast carcinoma xenograft models
  2. Fichtner, I.; Monks, A.; Hose, C.; Stevens, M. F. G.; Bradshaw, T. D.
  3. Breast Cancer Research and Treatment. 2004, SEP; 87(1): 97-107.
  1. 12.   Potential prodrugs of nitric oxide-releasing PROLI/NO
  2. Showalter, B. M.; Saavedra, J. E.; Citron, M. L.; Keefer, L. K.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(237-MEDI, Part 2): U49-U49.
  1. 13.   Analytical challenges faced in designing potential anticancer agents from nitric oxide (NO)-releasing diazeniumdiolate prodrugs
  2. Waterhouse, D. J.; Saavedra, J. E.; Citro, M. L.; Buzard, G. S.; Ji, X. H.; Xu, X.; Fox, S. D.; Veenstra, T. D.; Keefer, L. K.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(081-ANYL, Part 1): U91-U91.
  1. 14.   Poly(ethylene glycol) prodrugs of the CDK inhibitor, alsterpaullone (NSC 705701): Synthesis and pharmacokinetic studies
  2. Greenwald, R. B.; Zhao, H.; Xia, J.; Wu, D. C.; Nervi, S.; Stinson, S. F.; Majerova, E.; Bramhall, C.; Zaharevitz, D. W.
  3. Bioconjugate Chemistry. 2004, SEP-OCT; 15(5): 1076-1083.
  1. 15.   Facile photochemical synthesis of mixed siloxyacetal glycosides as potential pH-sensitized prodrugs for selective treatment of solid tumors
  2. Svarovsky, S. A.; Taraban, M. B.; Barchi, J. J.
  3. Organic & Biomolecular Chemistry. 2004 2(21): 3155-3161.
  1. 16.   Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation
  2. Liu, J.; Li, C. X.; Qu, W.; Leslie, E.; Bonifant, C. L.; Buzard, G. S.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Molecular Cancer Therapeutics. 2004 3(6): 709-714.
  1. 17.   Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs
  2. Pettit, G. R.; Minardi, M. D.; Boyd, M. R.; Pettit, R. K.
  3. Anti-Cancer Drug Design. 2000 15(6): 397-403.
  1. 18.   Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A4
  2. Banwell, M. G.; Flynn, B. L.; Willis, A. C.; Hamel, E.
  3. Australian Journal of Chemistry. 1999 52(8): 767-774.
  1. 19.   Selective Pulmonary Vasodilation By Intravenous Infusion of an Ultrashort Half-Life Nucleophile Nitric Oxide Adduct
  2. Adrie, C.; Hirani, W. M.; Holzmann, A.; Keefer, L.; Zapol, W. M.; Hurford, W. E.
  3. Anesthesiology. 1998 88(1): 190-195.
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