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  1. 1.   The mechanism of Raf activation through dimerization
  2. Zhang,Mingzhen; Maloney,Ryan; Jang,Hyunbum; Nussinov,Ruth
  3. Chemical Science. 2021, Dec 08; 12(47): 15609-15619.
  1. 2.   Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sI(AHP), and its potentiation in hippocampal pyramidal neurons
  2. Tedoldi, Angelo; Ludwig, Petra; Fulgenzi,Gianluca; Takeshima, Hiroshi; Pedarzani, Paola; Stocker, Martin
  3. PLOS ONE. 2020, JUN 19; 15(7):
  1. 3.   Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
  2. Kondo, Yasushi; Ognjenovic,Jana; Banerjee, Saikat; Karandur, Deepti; Merk,Alan; Kulhanek, Kayla; Wong, Kathryn; Roose, Jeroen P.; Subramaniam, Sriram; Kuriyan, John
  3. SCIENCE. 2019, OCT 4; 366(6461): 109-+.
  1. 4.   Threonine Tyrosine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
  2. Zheng, Lin; Chen, Zibo; Kawakami, Masanori; Chen, Yulong; Roszik, Jason; Mustachio, Lisa Maria; Kurie, Jonathan M; Villalobos, Pamela; Lu, Wei; Behren, Carmen; Mino, Barbara; Solis, Luisa M; Silvester, Jennifer; Thu, Kelsie L; Cescon, David W; Rodriguez-Canales, Jaime; Wistuba, Ignacio I; Mak, Tak W; Liu, Xi; Dmitrovsky,Ethan
  3. Molecular cancer therapeutics. 2019, OCT; 18(10): 1775-1786.
  1. 5.   Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence
  2. Ramakrishna, Sneha; Highfill, Steven L.; Walsh, Zachary; Nguyen, Sang M.; Lei, Haiyan; Shern, Jack F.; Qin, Haiying; Kraft, Ira L.; Stetler-Stevenson, Maryalice; Yuan, Constance M.; Hwang, Jennifer D.; Feng,Yang; Zhu, Zhongyu; Dimitrov, Dimiter; Shah, Nirali N.; Fry, Terry J.
  3. CLINICAL CANCER RESEARCH. 2019, Sep 1; 25(17): 5329-5341.
  1. 6.   Structures of the PKA RI alpha Holoenzyme with the FLHCC Driver J-PKAc alpha or Wild-Type PKAc alpha
  2. Cao,Baohua; Lu, Tsan-Wen; Martinez Fiesco,Juliana; Tomasini, Michael; Fan,Lixin; Simon, Sanford M.; Taylor, Susan S.; Zhang,Ping
  3. Structure (London, England : 1993). 2019, MAY 7; 27(5): 816-+.
  1. 7.   Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90
  2. Sager, Rebecca A.; Woodford, Mark R.; Backe, Sarah J.; Makedon, Alan M.; Baker-Williams, Alexander J.; DiGregorio, Bryanna T.; Loiselle, David R.; Haystead, Timothy A.; Zachara, Natasha E.; Prodromou, Chrisostomos; Bourboulia, Dimitra; Schmidt,Laura; Linehan, W. Marston; Bratslavsky, Gennady; Mollapour, Mehdi
  3. Cell reports. 2019, Jan 29; 26(5): 1344-1356.e5.
  1. 8.   Allosteric activation of RAF in the MAPK signaling pathway
  2. Tsai,Chung-Jung; Nussinov,Ruth
  3. CURRENT OPINION IN STRUCTURAL BIOLOGY. 2018, Dec; 53: 100-106.
  1. 9.   Crosstalk between PKC alpha and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium
  2. Hsu, Alice; Lum, Michelle A.; Shim, Kang-Sup; Frederick, Peter J.; Morrison, Carl D.; Chen, Baojiang; Lele, Subodh M.; Sheinin, Yuri M.; Daikoku, Takiko; Dey, Sudhansu K.; Leone, Gustavo; Black, Adrian R.; Black, Jennifer D.
  3. CELL REPORTS. 2018, Jul 17; 24(3): 655-669.
  1. 10.   Cell-free formation and interactome analysis of caveolae
  2. Jung, Wooram; Sierecki, Emma; Bastiani, Michele; O'Carroll, Ailis; Alexandrov, Kirill; Rae, James; Johnston, Wayne; Hunter, Dominic J. B.; Ferguson, Charles; Gambin, Yann; Ariotti, Nicholas; Parton, Robert G.
  3. Journal of Cell Biology. 2018, Jun 04; 217(6): 2141-2165.
  1. 11.   Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via G beta gamma/PKC/ERK1/2 pathway and heterologous receptor desensitization
  2. Shi, Ying; Lai, Xiangru; Ye, Lingyan; Chen, Keqiang; Cao, Zheng; Gong, Wang; Jin, Lili; Wang, Chunyan; Liu, Mingyong; Liao, Yuan; Wang, Jiming; Zhou, Naiming
  3. SCIENTIFIC REPORTS. 2017, Feb 10; 7: 42279.
  1. 12.   Negative regulation of human U6 snRNA promoter by p38 kinase through Oct-1
  2. Lin, B. R.; Natarajan, V.
  3. Gene. 2012, Apr; 497(2): 200-207.
  1. 13.   CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute
  2. Zoppoli, G.; Solier, S.; Reinhold, W. C.; Liu, H.; Connelly, J. W.; Monks, A.; Shoemaker, R. H.; Abaan, O. D.; Davis, S. R.; Meltzer, P. S.; Doroshow, J. H.; Pommier, Y.
  3. Oncogene. 2012, Jan; 31(4): 403-418.
  1. 14.   Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy
  2. Lountos, G. T.; Jobson, A. G.; Tropea, J. E.; Self, C. R.; Zhang, G. T.; Pommier, Y.; Shoemaker, R. H.; Waugh, D. S.
  3. Journal of Structural Biology. 2011, Dec; 176(3): 292-301.
  1. 15.   X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket
  2. Lountos, G. T.; Jobson, A. G.; Tropea, J. E.; Self, C. R.; Zhang, G. T.; Pommier, Y.; Shoemaker, R. H.; Waugh, D. S.
  3. Febs Letters. 2011, Oct; 585(20): 3245-3249.
  1. 16.   N-Methyl-Substituted Fluorescent DAG-Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity
  2. Gal, N.; Kolusheva, S.; Kedei, N.; Telek, A.; Naeem, T. A.; Lewin, N. E.; Lim, L.; Mannan, P.; Garfield, S. H.; El Kazzouli, S.; Sigano, D. M.; Marquez, V. E.; Blumberg, P. M.; Jelinek, R.
  3. Chembiochem. 2011, Oct; 12(15): 2331-2340.
  1. 17.   LIM kinase 1-dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes
  2. Ishaq, M.; Lin, B. R.; Bosche, M.; Zheng, X.; Yang, J.; Huang, D. W.; Lempicki, R. A.; Natarajan, V.
  3. Bmc Molecular Biology. 2011, Sep; 12: 14.
  1. 18.   Effect of nitric oxide on neointimal hyperplasia based on sex and hormone status
  2. Hogg, M. E.; Varu, V. N.; Vavra, A. K.; Popowich, D. A.; Banerjee, M. N.; Martinez, J.; Jiang, Q.; Saavedra, J. E.; Keefer, L. K.; Kibbe, M. R.
  3. Free Radical Biology and Medicine. 2011, May; 50(9): 1065-1074.
  1. 19.   Toll-Like Receptor 9 Is Required for Opioid-Induced Microglia Apoptosis
  2. He, L.; Li, H.; Chen, L.; Miao, J. Y.; Jiang, Y. L.; Zhang, Y.; Xiao, Z. X.; Hanley, G.; Li, Y.; Zhang, X. M.; LeSage, G.; Peng, Y.; Yin, D. L.
  3. Plos One. 2011, Apr; 6(4): 10.
  1. 20.   Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats
  2. Yang, Z. W.; Li, D. J.; Liu, C.; Han, P.; Yang, Y. L.; Su, D. F.; Shen, F. M.
  3. Acta Pharmacologica Sinica. 2011, Feb; 32(2): 194-200.
  1. 21.   AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
  2. Smith, F. D.; Langeberg, L. K.; Cellurale, C.; Pawson, T.; Morrison, D. K.; Davis, R. J.; Scott, J. D.
  3. Nature Cell Biology. 2010, Dec; 12(12): 1242-U287.
  1. 22.   Allosteric Regulation of Glycogen Synthase Kinase 3 beta: A Theoretical Study
  2. Buch, I.; Fishelovitch, D.; London, N.; Raveh, B.; Wolfson, H. J.; Nussinov, R.
  3. Biochemistry. 2010, Dec; 49(51): 10890-10901.
  1. 23.   TRPM7 is essential for Mg2+ homeostasis in mammals
  2. Ryazanova, L. V.; Rondon, L. J.; Zierler, S.; Hu, Z. X.; Galli, J.; Yamaguchi, T. P.; Mazur, A.; Fleig, A.; Ryazanov, A. G.
  3. Nature Communications. 2010, Nov; 1: 9.
  1. 24.   Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease
  2. Cabarcas, S. M.; Hurt, E. M.; Farrar, W. L.
  3. Current Molecular Medicine. 2010, Nov; 10(8): 741-755.
  1. 25.   Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities
  2. Raifman, O.; Kolusheva, S.; El Kazzouli, S.; Sigano, D. M.; Kedei, N.; Lewin, N. E.; Lopez-Nicolas, R.; Ortiz-Espin, A.; Gomez-Fernandez, J. C.; Blumberg, P. M.; Marquez, V. E.; Corbalan-Garcia, S.; Jelinek, R.
  3. Chembiochem. 2010, Sep; 11(14): 2003-2009.
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