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  1. 1.   Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus
  2. Zhou, D. W.; Chung, S. H.; Miller, M.; Le Grice, S. F. J.; Wlodawer, A.
  3. Journal of Structural Biology. 2012, Mar; 177(3): 638-645.
  1. 2.   Mechanisms and Factors that Influence High Frequency Retroviral Recombination
  2. Delviks-Frankenberry, K.; Galli, A.; Nikolaitchik, O.; Mens, H.; Pathak, V. K.; Hu, W. S.
  3. Viruses-Basel. 2011, Sep; 3(9): 1650-1680.
  1. 3.   Synthesis, Activity, and Structural Analysis of Novel alpha-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H
  2. Chung, S. M.; Himmel, D. M.; Jiang, J. K.; Wojtak, K.; Bauman, J. D.; Rausch, J. W.; Wilson, J. A.; Beutler, J. A.; Thomas, C. J.; Arnold, E.; Le Grice, S. F. J.
  3. Journal of Medicinal Chemistry. 2011, Jul; 54(13): 4462-4473.
  1. 4.   Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors
  2. Nikolenko, G. N.; Kotelkin, A. T.; Oreshkova, S. F.; Ilyichev, A. A.
  3. Molecular Biology. 2011, Feb; 45(1): 93-109.
  1. 5.   Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
  2. Chung, S. M.; Wendeler, M.; Rausch, J. W.; Beilhartz, G.; Gotte, M.; O'Keefe, B. R.; Bermingham, A.; Beutler, J. A.; Liu, S. X.; Zhuang, X. W.; Le Grice, S. F. J.
  3. Antimicrobial Agents and Chemotherapy. 2010, Sep; 54(9): 3913-3921.
  1. 6.   Reverse transcriptase in motion: Conformational dynamics of enzyme-substrate interactions
  2. Gotte, M.; Rausch, J. W.; March, B.; Sarafianos, S.; Le Grice, S. F. J.
  3. Biochimica Et Biophysica Acta-Proteins and Proteomics. 2010, May; 1804(5): 1202-1212.
  1. 7.   A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
  2. Nikolenko, G. N.; Delviks-Frankenberry, K. A.; Pathak, V. K.
  3. Journal of Virology. 2010, May; 84(10): 5238-5249.
  1. 8.   Synthesis of nucleoside 5 '-O-alpha,beta-methylene-beta-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase
  2. Ahmadibeni, Y.; Dash, C.; Hanley, M. J.; Le Grice, S. F. J.; Agarwal, H. K.; Parang, K.
  3. Organic & Biomolecular Chemistry. 2010, Mar; 8(6): 1271-1274.
  1. 9.   The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
  2. Abram, M. E.; Sarafianos, S. G.; Parniak, M. A.
  3. Retrovirology. 2010, Feb; 7: 9.
  1. 10.   Revisiting Plus-Strand DNA Synthesis in Retroviruses and Long Terminal Repeat Retrotransposons: Dynamics of Enzyme: Substrate Interactions
  2. Fabris, D.; Marino, J. P.; Le Grice, S. F. J.
  3. Viruses-Basel. 2009, Dec; 1(3): 657-677.
  1. 11.   Subtype-Specific Differences in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Connection Subdomain of CRF01_AE Are Associated with Higher Levels of Resistance to 3 '-Azido-3 '-Deoxythymidine
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Maldarelli, F.; Hase, S.; Takebe, Y.; Pathak, V. K.
  3. Journal of Virology. 2009 83(17): 8502-8513.
  1. 12.   Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
  2. Dunn, L. L.; McWilliams, M. J.; Das, K.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2009 83(23): 12336-12344.
  1. 13.   Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
  2. Post, K.; Kankia, B.; Gopalakrishnan, S.; Yang, V.; Cramer, E.; Saladores, P.; Gorelick, R. J.; Guo, J. H.; Musier-Forsyth, K.; Levin, J. G.
  3. Nucleic Acids Research. 2009 37(6): 1755-1766.
  1. 14.   A Succession of Mechanisms Stimulate Efficient Reconstituted HIV-1 Minus Strand Strong Stop DNA Transfer
  2. Song, M.; Balakrishnan, M.; Gorelick, R. J.; Bambara, R. A.
  3. Biochemistry. 2009 48(8): 1810-1819.
  1. 15.   Dynamic binding orientations direct activity of HIV reverse transcriptase
  2. Abbondanzieri, E. A.; Bokinsky, G.; Rausch, J. W.; Zhang, J. X.; Le Grice, S.; Zhuang, X. W.
  3. Nature. 2008 453(7192): 184-189.
  1. 16.   The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase
  2. Chang, K. W.; Oh, J.; Alvord, W. G.; Hughes, S. H.
  3. Journal of Virology. 2008 82(17): 8592-8604.
  1. 17.   Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect
  2. Gao, L.; Hanson, M. N.; Balakrishnan, M.; Boyer, P. L.; Roques, B. P.; Hughes, S. H.; Kim, B.; Bambara, R. A.
  3. Journal of Biological Chemistry. 2008 283(14): 9196-9205.
  1. 18.   Integration of Rous Sarcoma Virus DNA: a CA Dinucleotide Is Not Required for Integration of the U3 End of Viral DNA
  2. Oh, J.; Chang, K. W.; Hughes, S. H.
  3. Journal of Virology. 2008 82(22): 11480-11483.
  1. 19.   Rous sarcoma virus (RSV) integration in vivo: a CA dinucleotide is not required in U3, and RSV linear DNA does not autointegrate
  2. Oh, J.; Chang, K. W.; Wierzchoslawski, R.; Alvord, W. G.; Hughes, S. H.
  3. Journal of Virology. 2008 82(1): 503-512.
  1. 20.   Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity
  2. Wendeler, M.; Lee, H. F.; Bermingham, A.; Miller, J. T.; Chertov, O.; Bona, M. K.; Baichoo, N. S.; Ehteshami, M.; Beutler, J.; O'Keefe, B. R.; Gotte, M.; Kvaratskhelia, M.; Le Grice, S.
  3. Acs Chemical Biology. 2008 3(10): 635-644.
  1. 21.   Human T-cell leukemia virus type 1 integration target sites in the human genome: Comparison with those of other retroviruses
  2. Derse, D.; Crise, B.; Li, Y.; Princler, G.; Lum, N.; Stewart, C.; McGrath, C. F.; Hughes, S. H.; Munroe, D. J.; Wu, X. L.
  3. Journal of Virology. 2007, Jun; 81(12): 6731-6741.
  1. 22.   Analysis of amino acids in the beta 7-beta 8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication
  2. Mulky, A.; Vu, B. C.; Conway, J. A.; Hughes, S. H.; Kappes, J. C.
  3. Journal of Molecular Biology. 2007, Feb; 365(5): 1368-1378.
  1. 23.   Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis
  2. Rausch, J. W.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2007, Jan; 35(1): 256-268.
  1. 24.   Mutations in the connection domain of HIV-1 reverse transcriptase increase 3 '-azido-3 '-deoxythymidine resistance
  2. Nikolenko, G. N.; Delviks-Frankenberry, K. A.; Palmer, S.; Maldarelli, F.; Fivash, M. J.; Coffin, J. M.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2007, Jan; 104(1): 317-322.
  1. 25.   Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes
  2. Rausch, J. W.; Le Grice, S. F. J.
  3. Current HIV Research. 2007, Jan; 5(1): 11-22.
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