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  1. 1.   RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
  2. Sebastiani, Jessica; Puxeddu, Michela; Nalli, Marianna; Bai,Ruoli; Altieri, Ludovica; Rovella, Paola; Gaudio, Eugenio; Trisciuoglio, Daniela; Spriano, Filippo; Lavia, Patrizia; Fionda, Cinzia; Masci, Domiziana; Urbani, Andrea; Bigogno, Chiara; Dondio, Giulio; Hamel,Ernest; Bertoni, Francesco; Silvestri, Romano; La Regina, Giuseppe
  3. European Journal of Medicinal Chemistry. 2022, Dec 05; 246: 114997.
  1. 2.   Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide-chlorambucil conjugate
  2. Funasaki, Shintaro; Mehanna, Sally; Ma, Wenjuan; Nishizawa, Hidekazu; Kamikubo, Yasuhiko; Sugiyama, Hiroshi; Ikeda, Shuji; Motoshima, Takanobu; Hasumi, Hisashi; Linehan, W Marston; Schmidt,Laura; Ricketts, Chris; Suda, Toshio; Oike, Yuichi; Kamba, Tomomi; Baba, Masaya
  3. Cancer Science. 2022, Apr 09;
  1. 3.   Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Bufano, Marianna; Nalli, Marianna; Sebastiani, Jessica; Brancaccio, Diego; Da Pozzo, Eleonora; Tremolanti, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Sinicropi, Maria Stefania; Ceramella, Jessica; Iacopetta, Domenico; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2021, Oct 5; 221
  1. 4.   Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana
  2. Jiang, Wei; Wang,Dongdong; Wilson,Brice; Kang, Unwoo; Bokesch, Heidi R; Smith,Emily; Wamiru,Antony; Goncharova,Katya; Voeller, Donna; Lipkowitz, Stanley; O'Keefe,Barry; Gustafson,Kirk
  3. Marine drugs. 2021, Jun 24; 19(7):
  1. 5.   The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
  2. Xu,Xiaoping; Ni, Kai; He,Yafeng; Ren, Jianke; Sun, Chongkui; Liu, Yie; Aladjem, Mirit; Burkett, Sandra; Finney, Richard; Ding, Xia; Sharan,Shyam; Muegge,Kathrin
  3. Nature communications. 2021, Jun 10; 12(1):
  1. 6.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 7.   A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays
  2. Biswas,Kajal; Lipton, Gary B; Stauffer,Stacey; Sullivan,Teresa; Cleveland, Linda; Southon,Eileen; Reid,Susan; Magidson,Valentin; Iversen, Edwin S; Sharan,Shyam
  3. NPJ genomic medicine. 2020, Dec 08; 5(1): 52.
  1. 8.   Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
  2. Sebastian, Robin; Hosogane, Eri K; Sun, Eric G; Tran, Andy D; Reinhold, William C; Burkett,Sandra; Sturgill, David M; Gudla, Prabhakar R; Pommier, Yves; Aladjem, Mirit I; Oberdoerffer, Philipp
  3. Molecular cell. 2020, SEP 3; 79(5): 836-+.
  1. 9.   Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Nalli, Marianna; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Mazzoni, Cristina; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2020, Jan 1; 185: 111828.
  1. 10.   The Regulatory Role of MicroRNA in Hepatitis-B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) Pathogenesis
  2. Sartorius, Kurt; Makarova, Julia; Sartorius, Benn; An,Ping; Winkler,Cheryl; Chuturgoon, Anil; Kramvis, Anna
  3. Cells. 2019, DEC; 8(12):
  1. 11.   IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion
  2. Conlon, Kevin C.; Potter, E. Lake; Pittaluga, Stefania; Lee, Chyi-Chia Richard; Miljkovic, Milos D.; Fleisher, Thomas A.; Dubois, Sigrid; Bryant, Bonita R.; Petrus, Michael; Perera, Liyanage P.; Hsu, Jennifer; Figg, William D.; Peer, Cody J.; Shih, Joanna H.; Yovandich,Jason; Creekmore,Stephen; Roederer, Mario; Waldmann, Thomas A.
  3. CLINICAL CANCER RESEARCH. 2019, Aug 15; 25(16): 4945-4954.
  1. 12.   Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit
  2. Wang, Guanqiao; Zhang, Mingzhen; Jang, Hyunbum; Lu, Shaoyong; Lin, Shizhou; Chen, Guoqiang; Nussinov, Ruth; Zhang, Jian; Gaponenko, Vadim
  3. Biochemistry. 2018, Mar 27; 57(12): 1917-1928.
  1. 13.   3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin
  2. La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, Vitalba; Agriesti, Francesca; Piccoli, Claudia; Tataranni, Tiziana; Nalli, Marianna; Brancale, Andrea; Vultaggio, Stefania; Mercurio, Ciro; Varasi, Mario; Saponaro, Concetta; Sergio, Sara; Maffia, Michele; Coluccia, Addolorata Maria Luce; Hamel, Ernest; Silvestri, Romano
  3. ACS Medicinal Chemistry Letters. 2017, Apr 26; 8(5): 521-526.
  1. 14.   IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity
  2. Shirota, Hidekazu; Klinman, Dennis; Ito, Shuku-ei; Ito, Hiroyasu; Kubo, Masato; Ishioka, Chikashi
  3. CANCER IMMUNOLOGY RESEARCH. 2017, Jan; 5(1): 61-71.
  1. 15.   Centriole Remodeling during Spermiogenesis in Drosophila
  2. Khire, Atul; Jo, Kyoung H.; Kong, Dong; Akhshi, Tara; Blachon, Stephanie; Cekic, Anthony R.; Hynek, Sarah; Ha, Andrew; Loncarek, Jadranka; Mennella, Vito; Avidor-Reiss, Tomer
  3. CURRENT BIOLOGY. 2016, Dec 5; 26(23): 3183-3189.
  1. 16.   Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect
  2. Thomas, J. A.; Shatzer, T. L.; Gorelick, R. J.
  3. Retrovirology. 2011, Jun; 8: 14.
  1. 17.   Structure of human dual-specificity phosphatase 27 at 2.38 angstrom resolution
  2. Lountos, G. T.; Tropea, J. E.; Waugh, D. S.
  3. Acta Crystallographica Section D-Biological Crystallography. 2011, May; 67: 471-479.
  1. 18.   Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
  2. Crea, F.; Hurt, E. M.; Mathews, L. A.; Cabarcas, S. M.; Sun, L.; Marquez, V. E.; Danesi, R.; Farrar, W. L.
  3. Molecular Cancer. 2011, Apr; 10: 10.
  1. 19.   Polymorphic C-terminal beta-Sheet Interactions Determine the Formation of Fibril or Amyloid beta-derived Diffusible Ligand-like Globulomer for the Alzheimer A beta 42 Dodecamer
  2. Ma, B. Y.; Nussinov, R.
  3. Journal of Biological Chemistry. 2010, Nov; 285(47): 37102-37110.
  1. 20.   Role of Phosphatidylinositol 3-Kinase in Friend Spleen Focus-Forming Virus-Induced Erythroid Disease
  2. Umehara, D.; Watanabe, S.; Ochi, H.; Anai, Y.; Ahmed, N.; Kannagi, M.; Hanson, C.; Ruscetti, S.; Nishigaki, K.
  3. Journal of Virology. 2010, Aug; 84(15): 7675-7682.
  1. 21.   Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes
  2. Dahle, O.; Kumar, A.; Kuehn, M. R.
  3. Science Signaling. 2010, Jun; 3(127): 8.
  1. 22.   Natural product scaffolds as leads-to drugs
  2. Newman, D. J.; Cragg, G. M.
  3. Future Medicinal Chemistry. 2009, Nov; 1(8): 1415-1427.
  1. 23.   Alternatively Activated and Immunoregulatory Monocytes in Human Filarial Infections
  2. Babu, S.; Kumaraswami, V.; Nutman, T. B.
  3. Journal of Infectious Diseases. 2009 199(12): 1827-1837.
  1. 24.   Role of Proinflammatory Cytokines IL-18 and IL-1 beta in Bleomycin-Induced Lung Injury in Humans and Mice
  2. Hoshino, T.; Okamoto, M.; Sakazaki, Y.; Kato, S.; Young, H. A.; Aizawal, H.
  3. American Journal of Respiratory Cell and Molecular Biology. 2009 41(6): 661-670.
  1. 25.   Variants in Interferon-Alpha Pathway Genes and Response to Pegylated Interferon-Alpha2a Plus Ribavirin for Treatment of Chronic Hepatitis C Virus Infection in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial
  2. Welzel, T. M.; Morgan, T. R.; Bonkovsky, H. L.; Naishadham, D.; Pfeiffer, R. M.; Wright, E. C.; Hutchinson, A. A.; Crenshaw, A. T.; Bashirova, A.; Carrington, M.; Dotrang, M.; Sterling, R. K.; Lindsay, K. L.; Fontana, R. J.; Lee, W. M.
  3. Hepatology. 2009 49(6): 1847-1858.
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