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  1. 1.   Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy
  2. Lountos, G. T.; Jobson, A. G.; Tropea, J. E.; Self, C. R.; Zhang, G. T.; Pommier, Y.; Shoemaker, R. H.; Waugh, D. S.
  3. Journal of Structural Biology. 2011, Dec; 176(3): 292-301.
  1. 2.   X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket
  2. Lountos, G. T.; Jobson, A. G.; Tropea, J. E.; Self, C. R.; Zhang, G. T.; Pommier, Y.; Shoemaker, R. H.; Waugh, D. S.
  3. Febs Letters. 2011, Oct; 585(20): 3245-3249.
  1. 3.   Development of a High-Throughput Cell-Based Reporter Assay to Identify Stabilizers of Tumor Suppressor Pdcd4
  2. Blees, J. S.; Schmid, T.; Thomas, C. L.; Baker, A. R.; Benson, L.; Evans, J. R.; Goncharova, E. I.; Colburn, N. H.; McMahon, J. B.; Henrich, C. J.
  3. Journal of Biomolecular Screening. 2010, Jan; 15(1): 21-29.
  1. 4.   Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]
  2. Jobson, A. G.; Lountos, G. T.; Lorenzi, P. L.; Llamas, J.; Connelly, J.; Cerna, D.; Tropea, J. E.; Onda, A.; Zoppoli, G.; Kondapaka, S.; Zhang, G. T.; Caplen, N. J.; Cardellina, J. H.; Yoo, S. S.; Monks, A.; Self, C.; Waugh, D. S.; Shoemaker, R. H.
  3. Journal of Pharmacology and Experimental Therapeutics. 2009 331(3): 816-826.
  1. 5.   Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening
  2. Peach, M. L.; Tan, N.; Choyke, S. J.; Giubellino, A.; Athauda, G.; Burke, T. R.; Nicklaus, M. C.; Bottaro, D. P.
  3. Journal of Medicinal Chemistry. 2009 52(4): 943-951.
  1. 6.   Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
  2. Surazynski, A.; Liu, Y. M.; Miltyk, W.; Phang, J. M.
  3. Journal of Cellular Biochemistry. 2005, DEC 1; 96(5): 1086-1094.
  1. 7.   Transmembrane inhibitors of P-glycoprotein, an ABC transporter
  2. Tarasova, N. I.; Seth, R.; Tarasov, S. G.; Kosakowska-Cholody, T.; Hrycyna, C. A.; Gottesman, M. M.; Michejda, C. J.
  3. Journal of Medicinal Chemistry. 2005, JUN 2; 48(11): 3768-3775.
  1. 8.   The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries
  2. Kingston, D. G. I.; Newman, D. J.
  3. Current Opinion in Drug Discovery & Development. 2005, MAR; 8(2): 207-227.
  1. 9.   Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase
  2. Liu, Y. S.; Shreder, K. R.; Gai, W. Z.; Corral, S.; Ferris, D. K.; Rosenblum, J. S.
  3. Chemistry & Biology. 2005, JAN; 12(1): 99-107.
  1. 10.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 11.   7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr(308) but not Ser(473) phosphorylation: A basis for decreased insulin-stimulated glucose transport
  2. Kondapaka, S. B.; Zarnowski, M. J.; Yver, D. R.; Sausville, E. A.; Cushman, S. W.
  3. Clinical Cancer Research. 2004, NOV 1; 10(21): 7192-7198.
  1. 12.   Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors
  2. Sechi, M.; Derudas, M.; Dallocchio, R.; Dessi, A.; Bacchi, A.; Sannia, L.; Carta, F.; Palomba, M.; Ragab, O.; Chan, C.; Shoemaker, R.; Sei, S.; Dayam, R.; Neamati, N.
  3. Journal of Medicinal Chemistry. 2004, OCT 7; 47(21): 5298-5310.
  1. 13.   Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages
  2. Bosco, M. C.; Puppo, M.; Pastorino, S.; Mi, Z. H.; Melillo, G.; Massazza, S.; Rapisarda, A.; Varesio, L.
  3. Journal of Immunology. 2004 172(3): 1681-1690.
  1. 14.   Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression
  2. Schnier, J. B.; Nishi, K.; Monks, A.; Gorin, F. A.; Bradbury, E. M.
  3. Biochemical and Biophysical Research Communications. 2003 309(1): 126-134.
  1. 15.   Novel marine and microbial natural product inhibitors of vacuolar ATPase
  2. Beutler, J. A.; McKee, T. C.
  3. Current Medicinal Chemistry. 2003 10(9): 787-796.
  1. 16.   UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines
  2. Monks, A.; Harris, E. D.; Vaigro-Wolff, A.; Hose, C. D.; Connelly, J. W.; Sausville, E. A.
  3. Investigational New Drugs. 2000 18(2): 95-107.
  1. 17.   Subunit-Specific Mutagenesis of the Cysteine 280 Residue of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 - Effects On Sensitivity to a Specific Inhibitor of the Rnase H Activity
  2. Loya, S.; Gao, H. Q.; Avidan, O.; Boyer, P. L.; Hughes, S. H.; Hizi, A.
  3. Journal of Virology. 1997 71(7): 5668-5672.
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