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  1. 1.   Reverse transcriptase in motion: Conformational dynamics of enzyme-substrate interactions
  2. Gotte, M.; Rausch, J. W.; March, B.; Sarafianos, S.; Le Grice, S. F. J.
  3. Biochimica Et Biophysica Acta-Proteins and Proteomics. 2010, May; 1804(5): 1202-1212.
  1. 2.   In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity
  2. Jones, F. D.; Hughes, S. H.
  3. Virology. 2007, Apr; 360(2): 341-349.
  1. 3.   Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis
  2. Rausch, J. W.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2007, Jan; 35(1): 256-268.
  1. 4.   Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization
  2. McWilliams, M. J.; Julias, J. G.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Virology. 2006, May; 348(2): 378-388.
  1. 5.   Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer
  2. Yi-Brunozzi, H. Y.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2005, MAY 20; 280(20): 20154-20162.
  1. 6.   Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
  2. Julias, J. G.; McWilliams, M. J.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, DEC; 78(23): 13315-13324.
  1. 7.   Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection
  2. Rausch, J. W.; Qu, J.; Yi-Brunozzi, H. Y.; Kool, E. T.; Le Grice, S. F. J.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2003 100(20): 11279-11284.
  1. 8.   Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase
  2. Lener, D.; Kvaratskhelia, M.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2003 278(29): 26526-26532.
  1. 9.   Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity
  2. Rausch, J. W.; Lener, D.; Miller, J. T.; Julias, J. G.; Hughes, S. H.; Le Grice, S. F. J.
  3. Biochemistry. 2002 41(15): 4856-4865.
  1. 10.   Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase
  2. Kvaratskhelia, M.; Budihas, S. R.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2002 277(19): 16689-16696.
  1. 11.   Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA : DNA
  2. Sarafianos, S. G.; Das, K.; Tantillo, C.; Clark, A. D.; Ding, J.; Whitcomb, J. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Embo Journal. 2001 20(6): 1449-1461.
  1. 12.   Maintenance of an Unusual Polypurine Tract in Hiv-2 - Stability to Passage in Culture
  2. Lauermann, V.; Hughes, S. H.; Peden, K. W. C.
  3. Virology. 1997 236(1): 208-212.
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