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  1. 1.   The mechanism of PI3K activation at the atomic level
  2. Zhang,Mingzhen; Jang,Hyunbum; Nussinov,Ruth
  3. Chemical science. 2019, Mar 28; 10(12): 3671-3680.
  1. 2.   Calmodulin (CaM) Activates PI3K alpha by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85 alpha
  2. Zhang,Mingzhen; Li, Zhigang; Wang, Guanqiao; Jang,Hyunbum; Sacks, David B.; Zhang, Jian; Gaponenko, Vadim; Nussinov,Ruth
  3. JOURNAL OF PHYSICAL CHEMISTRY B. 2018, Dec 13; 122(49): 11137-11146.
  1. 3.   Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit
  2. Wang, Guanqiao; Zhang, Mingzhen; Jang, Hyunbum; Lu, Shaoyong; Lin, Shizhou; Chen, Guoqiang; Nussinov, Ruth; Zhang, Jian; Gaponenko, Vadim
  3. Biochemistry. 2018, Mar 27; 57(12): 1917-1928.
  1. 4.   An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe
  2. Saio, T.; Ogura, K.; Shimizu, K.; Yokochi, M.; Burke, T. R.; Inagaki, F.
  3. Journal of Biomolecular Nmr. 2011, Nov; 51(3): 395-408.
  1. 5.   Selectivity and Mechanism of Action of a Growth Factor Receptor-Bound Protein 2 Src Homology 2 Domain Binding Antagonist
  2. Giubellino, A.; Shi, Z. D.; Jenkins, L.; Worthy, K. M.; Bindu, L. K.; Athauda, G.; Peruzzi, B.; Fisher, R. J.; Appella, E.; Burke, T. R.; Bottaro, D. P.
  3. Journal of Medicinal Chemistry. 2008 51(23): 7459-7468.
  1. 6.   EphrinB1 signals from the cell surface to the nucleus by recruitment of STAT3
  2. Bong, Y. S.; Lee, H. S.; Carim-Todd, L.; Mood, K.; Nishanian, T. G.; Tessarollo, L.; Daar, I. O.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2007, Oct; 104(44): 17305-17310.
  1. 7.   Preparation of orthogonally-protected 3-methoxy-4-phosphonomethyl-L-phenylalanine, a new reagent for the synthesis of phosphotyrosyl mimetic-containing peptides
  2. Choi, W. J.; Xang, S. U.; Burke, T. R.
  3. Letters in Organic Chemistry. 2007, Sep; 4(6): 433-439.
  1. 8.   Calorimetric investigation of phosphorylated and non-phosphorylated peptide ligand binding to the human Grb7-SH2 domain
  2. Spuches, A. M.; Argiros, H. J.; Lee, K. H.; Haas, L. L.; Perch, S. C.; Krag, D. N.; Roller, P. P.; Wilcox, D. E.; Lyons, B. A.
  3. Journal of Molecular Recognition. 2007, Jul-Aug; 20(4): 245-252.
  1. 9.   Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics
  2. Jiang, S.; Li, P.; Peach, M. L.; Bindu, L.; Worthy, K. W.; Fisher, R. J.; Burke, T. R.; Nicklaus, M.; Roller, P. P.
  3. Biochemical and Biophysical Research Communications. 2006, Oct; 349(2): 497-503.
  1. 10.   Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles
  2. Choi, W. J.; Shi, Z. D.; Worthy, K. M.; Bindu, L.; Karki, R. G.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry Letters. 2006, Oct; 16(20): 5265-5269.
  1. 11.   Design and concise synthesis of fully protected analogues of L-gamma-carboxyglutamic acid
  2. Jiang, S.; Li, P.; Lai, C. C.; Kelley, J. A.; Roller, P. P.
  3. Journal of Organic Chemistry. 2006, Sep; 71(19): 7307-7314.
  1. 12.   Development of Grb2 SH2 domain signaling antagonists: A potential new class of antiproliferative agents
  2. Burke, T. R.
  3. International Journal of Peptide Research and Therapeutics. 2006, Mar; 12(1): 33-48.
  1. 13.   Design and synthesis of phosphonodifluoromethyl phenylalanine (F(2)Pmp): A useful phosphotyrosyl mimetic
  2. Burke, T. R.
  3. Current Topics in Medicinal Chemistry. 2006 6(14): 1465-1471.
  1. 14.   A practical synthesis of fully protected L-gamma-carboxyglutamic acid
  2. Jiang, S.; Lai, C. C.; Kelley, J. A.; Roller, P. P.
  3. Tetrahedron Letters. 2006, Jan; 47(1): 23-25.
  1. 15.   Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
  2. Phan, J.; Shi, Z. D.; Burke, T. R.; Waugh, D. S.
  3. Journal of Molecular Biology. 2005, OCT 14; 353(1): 104-115.
  1. 16.   Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Liu, H. P.; Zhang, M. C.; Worthy, K. M.; Bindu, L.; Yang, D. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005, JUL 1; 13(13): 4200-4208.
  1. 17.   Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform
  2. Kang, S. U.; Shi, Z. D.; Worthy, K. M.; Bindu, L. K.; Dharmawardana, P. G.; Choyke, S. J.; Bottaro, D. P.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2005, JUN 16; 48(12): 3945-3948.
  1. 18.   Binding affinity difference induced by the stereochemistry of the sulfoxide bridge of the cyclic peptide inhibitors of Grb2-SH2 domain: NMR studies for the structural origin
  2. Shi, Y. H.; Song, Y. L.; Lin, D. H.; Tan, J. Z.; Roller, P. P.; Li, Q.; Long, Y. Q.; Song, G. Q.
  3. Biochemical and Biophysical Research Communications. 2005, MAY 20; 330(4): 1254-1261.
  1. 19.   Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles
  2. Oishi, S.; Shi, Z. D.; Worthy, K. M.; Bindu, L. K.; Fisher, R. J.; Burke, T. R.
  3. Chembiochem. 2005, APR; 6(4): 668-674.
  1. 20.   Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic
  2. Shi, Z. D.; Karki, R. G.; Oishi, S.; Worthy, K. M.; Bindu, L. K.; Dharmawardana, P. G.; Nicklaus, M. C.; Bottaro, D. P.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry Letters. 2005, MAR 1; 15(5): 1385-1388.
  1. 21.   Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics
  2. Oishi, S.; Karki, R. G.; Kang, S. U.; Wang, X. Z.; Worthy, K. M.; Bindu, L. K.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2005, FEB 10; 48(3): 764-772.
  1. 22.   Utilization of a common pathway for the synthesis of high affinity macrocyclic Grh2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction
  2. Shi, Z. D.; Karki, R. G.; Worthy, K. M.; Bindu, L. K.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Chemistry & Biodiversity. 2005 2(4): 447-456.
  1. 23.   Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface resonance plasmon technology
  2. Lung, F. D. T.; Chang, C. W.; Chong, M. C.; Liou, C. C.; Li, P.; Peach, M. L.; Nicklaus, M. C.; Lou, B. S.; Roller, P. P.
  3. Peptide Science (Biopolymers). 2005 80(5): 628-635.
  1. 24.   Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic
  2. Oishi, S.; Karki, R. G.; Shi, Z. D.; Worthy, K. M.; Bindu, L.; Chertov, O.; Esposito, D.; Frank, P.; Gillette, W. K.; Maderia, M.; Hartley, J.; Nicklaus, M. C.; Barchi, J. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005 13(7): 2431-2438.
  1. 25.   A one-step synthesis of N-alpha-Fmoc-4-O-[O ',O ''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine from commercially available starting material
  2. Kang, S. U.; Burke, T. R.
  3. Tetrahedron Letters. 2004, NOV 15; 45(47): 8611-8613.
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