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  1. 1.   The SRC family kinase inhibitor NXP900 demonstrates potent anti-tumor activity in squamous cell carcinomas
  2. Dash,Sweta; Hanson, Sabrina; King, Ben; Nyswaner, Katherine; Foss, Kelcie; Tesi,Noelle; Harvey, Mungo J B; Navarro-Marchal, Saúl A; Woods, Allison; Poradosu, Enrique; Unciti-Broceta, Asier; Carragher, Neil O; Brognard,John
  3. The Journal of Biological Chemistry. 2024, Jul 30; 107615.
  1. 2.   Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors
  2. Merida, Isabel; Arranz-Nicolás, Javier; Torres-Ayuso,Pedro; Ávila-Flores, Antonia
  3. Handbook of experimental pharmacology. 2019, Jun 22;
  1. 3.   Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy
  2. Logue, J. S.; Morrison, D. K.
  3. Genes & Development. 2012, Apr; 26(7): 641-650.
  1. 4.   Identification of a Src Tyrosine Kinase/SIAH2 E3 Ubiquitin Ligase Pathway That Regulates C/EBP delta Expression and Contributes to Transformation of Breast Tumor Cells
  2. Sarkar, T. R.; Sharan, S.; Wang, J.; Pawar, S. A.; Cantwell, C. A.; Johnson, P. F.; Morrison, D. K.; Wang, J. M.; Sterneck, E.
  3. Molecular and Cellular Biology. 2012, Jan; 32(2): 320-332.
  1. 5.   Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide
  2. Varricchio, L.; Migliaccio, A.; Castoria, G.; Yamaguchi, H.; de Falco, A.; Di Domenico, M.; Giovannelli, P.; Farrar, W.; Appella, E.; Auricchio, F.
  3. Molecular Cancer Research. 2007, Nov; 5(11): 1213-1221.
  1. 6.   Calorimetric investigation of phosphorylated and non-phosphorylated peptide ligand binding to the human Grb7-SH2 domain
  2. Spuches, A. M.; Argiros, H. J.; Lee, K. H.; Haas, L. L.; Perch, S. C.; Krag, D. N.; Roller, P. P.; Wilcox, D. E.; Lyons, B. A.
  3. Journal of Molecular Recognition. 2007, Jul-Aug; 20(4): 245-252.
  1. 7.   Development of Grb2 SH2 domain signaling antagonists: A potential new class of antiproliferative agents
  2. Burke, T. R.
  3. International Journal of Peptide Research and Therapeutics. 2006, Mar; 12(1): 33-48.
  1. 8.   Adaphostin targets Src and Zap-70 in addition to Bcr/abl kinase
  2. Kondapaka, S. B.; Sarangan, R.; Burke, J. R.; Mesner, K. K.; Shoemaker, R. H.
  3. Clinical Cancer Research. 2005, DEC 15; 11(24, Part 2 Suppl. S): 9162S-9162S.
  1. 9.   Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Liu, H. P.; Zhang, M. C.; Worthy, K. M.; Bindu, L.; Yang, D. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005, JUL 1; 13(13): 4200-4208.
  1. 10.   Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles
  2. Oishi, S.; Shi, Z. D.; Worthy, K. M.; Bindu, L. K.; Fisher, R. J.; Burke, T. R.
  3. Chembiochem. 2005, APR; 6(4): 668-674.
  1. 11.   Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics
  2. Oishi, S.; Karki, R. G.; Kang, S. U.; Wang, X. Z.; Worthy, K. M.; Bindu, L. K.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2005, FEB 10; 48(3): 764-772.
  1. 12.   Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic
  2. Oishi, S.; Karki, R. G.; Shi, Z. D.; Worthy, K. M.; Bindu, L.; Chertov, O.; Esposito, D.; Frank, P.; Gillette, W. K.; Maderia, M.; Hartley, J.; Nicklaus, M. C.; Barchi, J. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005 13(7): 2431-2438.
  1. 13.   Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells
  2. Shivakrupa, R.; Linnekin, D.
  3. Cellular Signalling. 2005, JAN; 17(1): 103-109.
  1. 14.   Tyr-298 in ephrinB1 is critical for an interaction with the Grb4 adaptor protein
  2. Bong, Y. S.; Park, Y. H.; Lee, H. S.; Mood, K.; Ishimura, A.; Daar, I. O.
  3. Biochemical Journal. 2004 377(Part 2): 499-507.
  1. 15.   Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation
  2. Gamero, A. M.; Sakamoto, S.; Montenegro, J.; Larner, A. C.
  3. Journal of Biological Chemistry. 2004 279(13): 12379-12385.
  1. 16.   Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity
  2. Li, P.; Zhang, M. C.; Peach, M. L.; Zhang, X. D.; Liu, H. P.; Nicklaus, M.; Yang, D. J.; Roller, P. P.
  3. Biochemical and Biophysical Research Communications. 2003 307(4): 1038-1044.
  1. 17.   Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics
  2. Li, P.; Zhang, M. C.; Long, Y. Q.; Peach, M. L.; Liu, H. P.; Yang, D. J.; Nicklaus, M.; Roller, P. P.
  3. Bioorganic & Medicinal Chemistry Letters. 2003 13(13): 2173-2177.
  1. 18.   Phosphatidylinositol 3 '-kinase is required for growth of mast cells expressing the Kit catalytic domain mutant
  2. Shivakrupa, R.; Bernstein, A.; Watring, N.; Linnekin, D.
  3. Cancer Research. 2003 63(15): 4412-4419.
  1. 19.   Synthesis of a phosphotyrosyl analogue having X-1, X-2 and phi angles constrained to values observed for an SH2 domain-bound phosphotyrosyl residue
  2. Wang, X. Z.; Yao, Z. J.; Liu, H. P.; Zhang, M. C.; Yang, D. J.; George, C.; Burke, T. R.
  3. Tetrahedron. 2003 59(32): 6087-6093.
  1. 20.   The role of glycosphingolipids in HIV signaling, entry and pathogenesis
  2. Viard, M.; Parolini, I.; Rawat, S. S.; Fecchi, K.; Sargiacomo, M.; Puri, A.; Blumenthal, R.
  3. Glycoconjugate Journal. 2003 20(3): 213-222.
  1. 21.   Phosphotyrosyl mimetics in the development of signal transduction inhibitors
  2. Burke, T. R.; Lee, K.
  3. Accounts of Chemical Research. 2003 36(6): 426-433.
  1. 22.   Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells
  2. Ptasznik, A.; Urbanowska, E.; Chinta, S.; Costa, M. A.; Katz, B. A.; Stanislaus, M. A.; Demir, G.; Linnekin, D.; Pan, Z. K.; Gewirtz, A. M.
  3. Journal of Experimental Medicine. 2002 196(5): 667-678.
  1. 23.   p60(v-src) and serum control cell shape and apoptosis via distinct pathways in quail neuroretina cells
  2. Aouacheria, A.; Ory, S.; Schmitt, J. R.; Rigal, D.; Jurdic, P.; Gillet, G.
  3. Oncogene. 2002 21(8): 1171-1186.
  1. 24.   Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7
  2. Pero, S. C.; Oligino, L.; Daly, R. J.; Soden, A. L.; Liu, C.; Roller, P. P.; Li, P.; Krag, D. N.
  3. Journal of Biological Chemistry. 2002 277(14): 11918-11926.
  1. 25.   Low-molecular-weight protein tyrosine phosphatase is a positive component of the fibroblast growth factor receptor signaling pathway
  2. Park, E. K.; Warner, N.; Mood, K.; Pawson, T.; Daar, I. O.
  3. Molecular and Cellular Biology. 2002 22(10): 3404-3414.
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