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  1. 1.   The "Connection" Between HIV Drug Resistance and RNase H
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Pathak, V. K.
  3. Viruses-Basel. 2010, Jul; 2(7): 1476-1503.
  1. 2.   Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3-Azido-3'-deoxythymidine resistance
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Barr, R.; Pathak, V. K.
  3. Journal of Virology. 2007, Jul; 81(13): 6837-6845.
  1. 3.   Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes
  2. Rausch, J. W.; Le Grice, S. F. J.
  3. Current HIV Research. 2007, Jan; 5(1): 11-22.
  1. 4.   Examining Ty3 polypurine tract structure and function by nucleoside analog interference
  2. Dash, C.; Marino, J. P.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2006, FEB 3; 281(5): 2773-2783.
  1. 5.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 6.   Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
  2. Nikolenko, G. N.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, FEB 8; 102(6): 2093-2098.
  1. 7.   Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase
  2. Bibillo, A.; Lener, D.; Klarmann, G. J.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(1): 171-181.
  1. 8.   Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
  2. Sarafianos, S. G.; Das, K.; Hughes, S. H.; Arnold, E.
  3. Current Opinion in Structural Biology. 2004, DEC; 14(6): 716-730.
  1. 9.   Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA
  2. Peletskaya, E. N.; Kogon, A. A.; Tuske, S.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004 78(7): 3387-3397.
  1. 10.   Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
  2. Tuske, S.; Sarafianos, S. G.; Clark, A. D.; Ding, J. P.; Naeger, L. K.; White, K. L.; Miller, M. D.; Gibbs, C. S.; Boyer, P. L.; Clark, P.; Wang, G.; Gaffney, B. L.; Jones, R. A.; Jerina, D. M.; Hughes, S. H.; Arnold, E.
  3. Nature Structural & Molecular Biology. 2004 11(5): 469-474.
  1. 11.   Trapping HIV-1 reverse transcriptase before and after translocation on DNA
  2. Sarafianos, S. G.; Clark, A. D.; Tuske, S.; Squire, C. J.; Das, K.; Sheng, D. Q.; Ilankumaran, P.; Ramesha, A. R.; Kroth, H.; Sayer, J. M.; Jerina, D. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Journal of Biological Chemistry. 2003 278(18): 16280-16288.
  1. 12.   Retroviral mutation rates and reverse transcriptase fidelity
  2. Svarovskaia, E. S.; Cheslock, S. R.; Zhang, W. H.; Hu, W. S.; Pathak, V. K.
  3. Frontiers in Bioscience. 2003 8: D117-D134.
  1. 13.   Site-specific mutagenesis in Escherichia coli by N-2- deoxyguanosine adducts derived from the highly carcinogenic fjord-region benzo c phenanthrene 3,4-diol 1,2-epoxides
  2. Ramos, L. A.; Ponten, I.; Dipple, A.; Kumar, S.; Yagi, H.; Sayer, J. M.; Kroth, H.; Kalena, G.; Jerina, D. M.
  3. Chemical Research in Toxicology. 2002 15(12): 1619-1626.
  1. 14.   Structures of HIV-1 reverse transcriptase with pre- and post- translocation AZTMP-terminated DNA
  2. Sarafianos, S. G.; Clark, A. D.; Das, K.; Tuske, S.; Birktoft, J. J.; Ilankumaran, P.; Ramesha, A. R.; Sayer, J. M.; Jerina, D. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Embo Journal. 2002 21(23): 6614-6624.
  1. 15.   Direct and indirect contributions of RNA secondary structure elements to the initiation of HIV-1 reverse transcription
  2. Goldschmidt, V.; Rigourd, M.; Ehresmann, C.; Le Grice, S. F. J.; Ehresmann, B.; Marquet, R.
  3. Journal of Biological Chemistry. 2002 277(45): 43233-43242.
  1. 16.   Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts
  2. Zhang, W. H.; Svarovskaia, E. S.; Barr, R.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2002 99(15): 10090-10095.
  1. 17.   HIV-1 reverse transcriptase interaction with model RNA-DNA duplexes
  2. Gorshkova, II; Rausch, J. W.; Le Grice, S. F. J.; Crouch, R. J.
  3. Analytical Biochemistry. 2001 291(2): 198-206.
  1. 18.   Effects of amino acid substitutions at position 115 on the fidelity of human immunodeficiency virus type 1 reverse transcriptase
  2. Boyer, P. L.; Hughes, S. H.
  3. Journal of Virology. 2000 74(14): 6494-6500.
  1. 19.   Inhibition of the initiation of HIV-1 reverse transcription by 3 '-azido-3 '-deoxythymidine - Comparison with elongation
  2. Rigourd, M.; Lanchy, J. M.; Le Grice, S. F. J.; Ehresmann, B.; Ehresmann, C.; Marquet, R.
  3. Journal of Biological Chemistry. 2000 275(35): 26944-26951.
  1. 20.   Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2000 97(7): 3056-3061.
  1. 21.   Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids
  2. Sarafianos, S. G.; Das, K.; Clark, A. D.; Ding, J. P.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 1999 96(18): 10027-10032.
  1. 22.   Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site
  2. Sarafianos, S. G.; Das, K.; Ding, J. P.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Chemistry & Biology. 1999 6(5): R137-R146.
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