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  1. 1.   Benzyl Ammonium Carbamates Undergo Two-Step Linker Cleavage and Improve the Properties of Antibody Conjugates
  2. Li,Xiaoyi; Patel,Nimit; Kalen,Joseph; Schnermann,Martin
  3. Angewandte Chemie (International ed. in English). 2024, Dec 18; e202417651.
  1. 2.   Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem
  2. Ataca, Sila; Sangesland, Maya; de Paiva Fróes Rocha, Rebeca; Torrents de la Peña, Alba; Ronsard, Larance; Boyoglu-Barnum, Seyhan; Gillespie, Rebecca A; Tsybovsky,Yaroslav; Stephens,Tyler; Moin, Syed M; Lederhofer, Julia; Creanga, Adrian; Andrews, Sarah F; Barnes, Ralston M; Rohrer, Daniel; Lonberg, Nils; Graham, Barney S; Ward, Andrew B; Lingwood, Daniel; Kanekiyo, Masaru
  3. Cell Reports. 2024, Nov 22; 43(12): 114990.
  1. 3.   The Janus kinase 1 is critical for pancreatic cancer initiation and progression
  2. Shrestha, Hridaya; Rädler, Patrick D; Dennaoui, Rayane; Wicker, Madison N; Rajbhandari, Nirakar; Sun, Yunguang; Peck, Amy R; Vistisen, Kerry; Triplett, Aleata A; Beydoun, Rafic; Sterneck,Esta; Saur, Dieter; Rui, Hallgeir; Wagner, Kay-Uwe
  3. Cell Reports. 2024, May 10; 43(5): 114202.
  1. 4.   Investigating the NRAS 5' UTR as a target for small molecules
  2. Balaratnam,Sumirtha; Torrey, Zachary R; Calabrese,Dave; Banco, Michael T; Yazdani, Kamyar; Liang, Xiao; Fullenkamp,Chris; Seshadri,Sri; Holewinski,Ronald; Andresson,Thorkell; Ferré-D'Amaré, Adrian R; Incarnato, Danny; Schneekloth,Jay
  3. Cell Chemical Biology. 2023, Jun 15; 30(6): 643-657.e8.
  1. 5.   Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site
  2. Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel,Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry. 2023, Feb 24; 82: 117217.
  1. 6.   Dual B-cell targeting therapy ameliorates autoimmune cholangitis
  2. Zhang, Weici; Shao, Tihong; Leung, Patrick S C; Tsuneyama, Koichi; Heuer, Luke; Young,Howard; Ridgway, William M; Gershwin, M Eric
  3. Journal of Autoimmunity. 2022, Aug 24; 132: 102897.
  1. 7.   Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities
  2. Romagnoli, Romeo; Oliva, Paola; Prencipe, Filippo; Manfredini, Stefano; Budassi, Federica; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Manfreda, Lorenzo; Mariotto, Elena; Bortolozzi, Roberta; Viola, Giampietro
  3. Pharmaceuticals (Basel, Switzerland). 2022, Aug 21; 15(8):
  1. 8.   Aminoflavone upregulates putative tumor suppressor miR-125b-2-3p to inhibit luminal A breast cancer stem cell-like properties
  2. Mavingire, Nicole; Campbell,Petreena; Liu, Tiantian; Wooten, Jonathan; Khan, Salma; Chen, Xin; Matthews, Jason; Wang, Charles; Brantley, Eileen
  3. Precision Clinical Medicine. 2022, Jun; 5(2): pbac008.
  1. 9.   Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
  2. Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Molecules . 2022, Jan 05; 27(1):
  1. 10.   Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents
  2. Islam, Farhana; Quadery, Tasdique M.; Bai,Ruoli; Luckett-Chastain, Lerin R.; Hamel,Ernest; Ihnat, Michael A.; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry Letters. 2021, Jun 1; 41
  1. 11.   Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer
  2. Choudhary, Shruti; Doshi, Arpit; Luckett-Chastain, Lerin; Ihnat, Michael; Hamel,Ernest; Mooberry, Susan L.; Gangjee, Aleem
  3. Bioogranic & Medicinal Chemistry. 2021, Apr 1; 35
  1. 12.   Inhibition of Nonfunctional Ras
  2. Nussinov,Ruth; Jang, Hyunbum; Gursoy, Attila; Keskin, Ozlem; Gaponenko, Vadim
  3. Cell Chemical Biology. 2021, Feb 18; 28(2): 121-133.
  1. 13.   The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity
  2. Xiang, Weiguo; Quadery, Tasdique M; Hamel,Ernest; Luckett-Chastain, Lerin R; Ihnat, Michael A; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & medicinal chemistry. 2021, Jan 1; 29: 115887.
  1. 14.   Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain
  2. Kim, Taejin; Viard,Mathias; Afonin, Kirill A; Gupta, Kshitij; Popov, Mary; Salotti,Jacqueline; Johnson,Peter; Linder, Charles; Heldman, Eliahu; Shapiro,Bruce
  3. Molecular therapy. Nucleic acids. 2020, JUN 5; 20: 359-372.
  1. 15.   Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting
  2. Agrawal, Mukta; Saraf, Swarnlata; Saraf, Shailendra; Dubey, Sunil Kumar; Puri,Anu; Patel, Ravish J.; Ravichandiran, V.; Murty, Upadhyayula Suryanarayana; Alexander, Amit
  3. Journal of controlled release : official journal of the Controlled Release Society. 2020, May 10; 321: 372-415.
  1. 16.   Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems
  2. Boer, Robert E.; Torrey, Zachary R.; Schneekloth,Jay
  3. ACS CHEMICAL BIOLOGY. 2020, Apr 17; 15(4): 808-818.
  1. 17.   Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA
  2. Dai, Yumin; Peralta, Ashley N.; Wynn, Jessica E.; Sherpa,Chringma; Li, Hao; Verma, Astha; Le Grice,Stuart; Santos, Webster L.
  3. Bioorganic & medicinal chemistry. 2019, APR 15; 27(8): 1759-1765.
  1. 18.   Cartilage-Targeted IGF-1 Treatment to Promote Longitudinal Bone Growth
  2. Lui, Julian C; Colbert, Max; Cheung, Crystal Sao Fong; Ad, Michal; Lee, Audrey; Zhu, Zhongyu; Barnes, Kevin M; Dimitrov, Dimiter S; Baron, Jeffrey
  3. Molecular therapy : the journal of the American Society of Gene Therapy. 2019, Mar 6; 27(3): 673-680.
  1. 19.   An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer
  2. Asampille, Gitanjali; Verma, Brijesh Kumar; Swain, Monalisa; Shettar, Abhijith; Rosenzweig, Steven A; Kondaiah, Paturu; Atreya, Hanudatta S
  3. Journal of nanobiotechnology. 2018, Dec 08; 16(1): 101.
  1. 20.   Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication
  2. Dai, Yumin; Wynn, Jessica E.; Peralta, Ashley N.; Sherpa,Chringma; Jayaraman, Bhargavi; Li, Hao; Verma, Astha; Frankel, Alan D.; Le Grice,Stuart; Santos, Webster L.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2018, NOV 8; 61(21): 9611-9620.
  1. 21.   Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents
  2. Pavana, Roheeth Kumar; Shah, Khushbu; Gentile, Taylor; Dybdal-Hargreaves, Nicholas F.; Risinger, April L.; Mooberry, Susan L.; Hamel, Ernest; Gangjee, Aleem
  3. BIOORGANIC & MEDICINAL CHEMISTRY. 2018, NOV 1; 26(20): 5470-5478.
  1. 22.   3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro
  3. Bioorganic chemistry. 2018, Oct; 80: 361-374.
  1. 23.   Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent
  2. Xiang, Weiguo; Choudhary, Shruti; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry. 2018, May 15; 26(9): 2437-2451.
  1. 24.   Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models
  2. Igarashi, Kentaro; Kawaguchi, Kei; Kiyuna, Tasuku; Miyake, Kentaro; Miyake, Masuyo; Singh, Arun S; Eckardt, Mark A; Nelson, Scott D; Russell, Tara A; Dry, Sarah M; Li, Yunfeng; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Tsuchiya, Hiroyuki; Singh, Shree Ram; Eilber, Fritz C; Hoffman, Robert M
  3. Biochemical and Biophysical Research Communications. 2018, Mar 18; 497(4): 1055-1061.
  1. 25.   Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo [3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple -acting angiokinase inhibition as antitumor agents
  2. Pavana, Roheeth Kumar; Choudhary, Shruti; Bastian, Anja; Ihnat, Michael A.; Bai, Ruoli; Hamel, Ernest; Gangjee, Aleem
  3. BIOORGANIC & MEDICINAL CHEMISTRY. 2017, Jan 15; 25(2): 545-556.
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