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  1. 1.   Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4
  2. Zhou, Bing-Rui; Feng, Hanqiao; Huang, Furong; Zhu, Iris; Portillo-Ledesma, Stephanie; Shi,Dan; Zaret, Kenneth S; Schlick, Tamar; Landsman, David; Wang, Qianben; Bai, Yawen
  3. Molecular Cell. 2024, Jul 31;
  1. 2.   Combination of Wnt/ß-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer
  2. Dahlmann, Mathias; Monks, Anne; Harris,Erik; Kobelt, Dennis; Osterland, Marc; Khaireddine, Fadi; Herrmann, Pia; Kemmner, Wolfgang; Burock, Susen; Walther, Wolfgang; Shoemaker, Robert H; Stein, Ulrike
  3. Cancers. 2021, Dec 22; 14(1):
  1. 3.   Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
  2. Niu, Haichan; Strecker, Tracy E.; Gerberich, Jeni L.; Campbell, James W.; Saha, Debabrata; Mondal, Deboprosad; Hamel,Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, JUN 13; 62(11): 5594-5615.
  1. 4.   Therapeutic vaccine to cure large mouse hepatocellular carcinomas.
  2. Han, Zhen; Yang, De; Trivett, Anna; Oppenheim, Joost
  3. Oncotarget. 2017, Aug 8; 8(32): 52061-52071.
  1. 5.   Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
  2. Pettit, G. R.; Rosenberg, H. J.; Dixon, R.; Knight, J. C.; Hamel, E.; Chapuis, J. C.; Pettit, R. K.; Hogan, F.; Sumner, B.; Ain, K. B.; Trickey-Platt, B.
  3. Journal of Natural Products. 2012, Mar; 75(3): 385-393.
  1. 6.   S100A4-induced cell motility and metastasis is restricted by the Wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells
  2. Sack, U.; Walther, W.; Scudiero, D.; Selby, M.; Aumann, J.; Lemos, C.; Fichtner, I.; Schlag, P. M.; Shoemaker, R. H.; Stein, U.
  3. Molecular Biology of the Cell. 2011, Sep; 22(18): 3344-3354.
  1. 7.   Population pharmacokinetic analysis of sorafenib in patients with solid tumours
  2. Jain, L.; Woo, S.; Gardner, E. R.; Dahut, W. L.; Kohn, E. C.; Kummar, S.; Mould, D. R.; Giaccone, G.; Yarchoan, R.; Venitz, J.; Figg, W. D.
  3. British Journal of Clinical Pharmacology. 2011, Aug; 72(2): 294-305.
  1. 8.   Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1
  2. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W.; Pettit, G. R.; Trawick, M. L.; Pinney, K. G.
  3. Journal of Natural Products. 2011, Jul; 74(7): 1568-1574.
  1. 9.   Intervening in beta-Catenin Signaling by Sulindac Inhibits S100A4-Dependent Colon Cancer Metastasis
  2. Stein, U.; Arlt, F.; Smith, J.; Sack, U.; Herrmann, P.; Walther, W.; Lemm, M.; Fichtner, I.; Shoemaker, R. H.; Schlag, P. M.
  3. Neoplasia. 2011, Feb; 13(2): 131-144.
  1. 10.   Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Cara, C. L.; Carrion, M. D.; Brancale, A.; Hamel, E.; Chen, L. C.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2010, May; 53(10): 4248-4258.
  1. 11.   E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes
  2. Pettit, R. K.; Pettit, G. R.; Hamel, E.; Hogan, F.; Moser, B. R.; Wolf, S.; Pon, S.; Chapuis, J. C.; Schmidt, J. M.
  3. Bioorganic & Medicinal Chemistry. 2009 17(18): 6606-6612.
  1. 12.   Design, synthesis and structure-activity relationship of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(19): 6862-6871.
  1. 13.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridi ne derivatives as antimitotic agents and inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Kandil, S.; Brancale, A.; Sarkar, T.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2008 18(18): 5041-5045.
  1. 14.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxyphenyisulfonyl)-5-aryl thiophenes as a new class of antitubulin agents
  2. Romagnoli, R.; Baraldi, P. G.; Remusat, V.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Fruttarolo, F.; Tabrizi, M. A.; Balzarini, J.; Hamel, E.
  3. Medicinal Chemistry. 2007, Nov; 3(6): 507-512.
  1. 15.   The pregnane X receptor gene-humanized mouse: A model for investigating drug-drug interactions mediated by cytochromes P450 3A
  2. Ma, X.; Shah, Y.; Cheung, C.; Guo, G. L.; Feigenbaum, L.; Krausz, K. W.; Idle, J. R.; Gonzalez, F. J.
  3. Drug Metabolism and Disposition. 2007, Feb; 35(2): 194-200.
  1. 16.   Structural dynamics of the cooperative binding of organic molecules in the human cytochrome P450 3A4
  2. Fishelovitch, D.; Hazan, C.; Shaik, S.; Wolfson, H. J.; Nussinov, R.
  3. Journal of the American Chemical Society. 2007, Feb; 129(6): 1602-1611.
  1. 17.   New arylthioindoles: Potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies
  2. De Martino, G.; Edler, M. C.; La Regina, G.; Coluccia, A.; Barbera, M. C.; Barrow, D.; Nicholson, R. I.; Chiosis, G.; Brancale, A.; Hamel, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2006, FEB 9; 49(3): 947-954.
  1. 18.   Structure-based discovery of a boronic acid bioisostere of combretastatin A-4
  2. Kong, Y.; Grembecka, J.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Sabat, M.; Rieger, J.; Brown, M. L.
  3. Chemistry & Biology. 2005, SEP; 12(9): 1007-1014.
  1. 19.   Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4
  2. Pettit, G. R.; Rhodes, M. R.; Herald, D. L.; Hamel, E.; Schmidt, J. M.; Pettitt, R. K.
  3. Journal of Medicinal Chemistry. 2005, JUN 16; 48(12): 4087-4099.
  1. 20.   Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype
  2. Kowara, R.; Karaczyn, A.; Cheng, R. Y. S.; Salnikow, K.; Kasprzak, K. S.
  3. Toxicology and Applied Pharmacology. 2005, MAY 15; 205(1): 1-10.
  1. 21.   The CYP2E1-humanized transgenic mouse: Role of CYP2E1 in acetaminophen hepatotoxicity
  2. Cheung, C.; Yu, A. M.; Ward, J. M.; Krausz, K. W.; Akiyama, T. E.; Feigenbaum, L.; Gonzalez, F. J.
  3. Drug Metabolism and Disposition. 2005, MAR; 33(3): 449-457.
  1. 22.   Arylthioindoles, potent inhibitors of tubulin polymerization
  2. De Martino, G.; La Regina, G.; Coluccia, A.; Edler, M. C.; Barbera, M. C.; Brancale, A.; Wilcox, E.; Hamel, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2004, DEC 2; 47(25): 6120-6123.
  1. 23.   A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel
  2. Dabydeen, D. A.; Florence, G. J.; Paterson, I.; Hamel, E.
  3. Cancer Chemotherapy and Pharmacology. 2004 53(5): 397-403.
  1. 24.   One-pot synthesis of benzo b furan and indole inhibitors of tubulin polymerization
  2. Flynn, B. L.; Hamel, E.; Jung, M. K.
  3. Journal of Medicinal Chemistry. 2002 45(12): 2670-2673.
  1. 25.   Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs
  2. Pettit, G. R.; Minardi, M. D.; Boyd, M. R.; Pettit, R. K.
  3. Anti-Cancer Drug Design. 2000 15(6): 397-403.
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