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  1. 1.   A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma
  2. Gaikwad, Snehal M; Phyo, Zaw; Arteaga, Anaisa Quintanilla; Gorjifard, Sayeh; Calabrese,Dave; Connors, Daniel; Huang, Jing; Michalowski, Aleksandra M; Zhang, Shuling; Liu, Zheng-Gang; Schneekloth,Jay; Mock, Beverly A
  3. Cancers. 2020, Oct 13; 12(10): pii: E2952.
  1. 2.   S-(4-methoxyphenyl)-4-methoxybenzenesulfonothioate as a promising lead compound for the development a renal carcinoma agent
  2. Namtes, Camila I; Pereira, Ingrid D; Bai,Ruoli; Hamel,Ernest; Burnett,Jim; de Oliveira, Rodrigo J; Matos, Maria de F C; Beatriz, Adilson; Yonekawa, Murilo K A; Perdomo, Renata T; de Lima, Dênis P; Bogo, Danielle; Dos Santos, Edson Dos Anjos
  3. ChemMedChem. 2020, JAN 16;
  1. 3.   The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  2. Ratner, Dmitry; Orning, M. Pontus A.; Proulx, Megan K.; Wang, Donghai; Gavrilin, Mikhail A.; Wewers, Mark D.; Alnemri, Emad S.; Johnson, Peter; Lee, Bettina; Mecsas, Joan; Kayagaki, Nobuhiko; Goguen, Jon D.; Lien, Egil
  3. PLOS PATHOGENS. 2016, Dec 2; 12(12): e1006035.
  1. 4.   Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
  2. Abnet, C. C.; Wang, Z. M.; Song, X.; Hu, N.; Zhou, F. Y.; Freedman, N. D.; Li, X. M.; Yu, K.; Shu, X. O.; Yuan, J. M.; Zheng, W.; Dawsey, S. M.; Liao, L. M.; Lee, M. P.; Ding, T.; Qiao, Y. L.; Gao, Y. T.; Koh, W. P.; Xiang, Y. B.; Tang, Z. Z.; Fan, J. H.; Chung, C. C.; Wang, C. Y.; Wheeler, W.; Yeager, M.; Yuenger, J.; Hutchinson, A.; Jacobs, K. B.; Giffen, C. A.; Burdett, L.; Fraumeni, J. F.; Tucker, M. A.; Chow, W. H.; Zhao, X. K.; Li, J. M.; Li, A. L.; Sun, L. D.; Wei, W.; Li, J. L.; Zhang, P.; Li, H. L.; Cui, W. Y.; Wang, W. P.; Liu, Z. C.; Yang, X.; Fu, W. J.; Cui, J. L.; Lin, H. L.; Zhu, W. L.; Liu, M.; Chen, X.; Chen, J.; Guo, L.; Han, J. J.; Zhou, S. L.; Huang, J.; Wu, Y.; Yuan, C.; Ji, A. F.; Kul, J. W.; Fan, Z. M.; Wang, J. P.; Zhang, D. Y.; Zhang, L. Q.; Zhang, W.; Chen, Y. F.; Ren, J. L.; Dong, J. C.; Xing, G. L.; Guo, Z. G.; Yang, J. X.; Mao, Y. M.; Yuan, Y.; Guo, E. T.; Hou, Z. C.; Liu, J.; Li, Y.; Tang, S.; Chang, J.; Peng, X. Q.; Han, M.; Yin, W. L.; Liu, Y. L.; Hu, Y. L.; Liu, Y.; Yang, L. Q.; Zhu, F. G.; Yang, X. F.; Feng, X. S.; Wang, Z.; Gao, S. G.; Liu, H. L.; Yuan, L.; Jin, Y.; Zhang, Y. R.; Sheyhidin, I.; Li, F.; Chen, B. P.; Ren, S. W.; Liu, B.; Li, D.; Zhang, G. F.; Yue, W. B.; Feng, C. W.; Qige, Q. R. W.; Zhao, J. T.; Yang, W. J.; Lei, G. Y.; Chen, L. Q.; Li, E. M.; Xu, L. Y.; Wu, Z. Y.; Bao, Z. Q.; Chen, J. L.; Li, X. C.; Zhuang, X.; Zhou, Y. F.; Zuo, X. B.; Dong, Z. M.; Wang, L. W.; Fan, X. P.; Wang, J.; Zhou, Q.; Ma, G. S.; Zhang, Q. X.; Liu, H.; Jian, X. Y.; Lian, S. Y.; Wang, J. S.; Chang, F. B.; Lu, C. D.; Miao, J. J.; Chen, Z. G.; Wang, R.; Guo, M.; Fan, Z. L.; Tao, P.; Liu, T. J.; Wei, J. C.; Kong, Q. P.; Fan, L.; Wang, X. Z.; Gao, F. S.; Wang, T. Y.; Xie, D.; Wang, L.; Chen, S. Q.; Yang, W. C.; Hong, J. Y.; Qiu, S. L.; Goldstein, A. M.; Yuan, Z. Q.; Chanock, S. J.; Zhang, X. J.; Taylor, P. R.; Wang, L. D.
  3. Human Molecular Genetics. 2012, May; 21(9): 2132-2141.
  1. 5.   JS-K, a Glutathione S-Transferase-Activated Nitric Oxide Donor With Antineoplastic Activity in Malignant Gliomas
  2. Weyerbrock, A.; Osterberg, N.; Psarras, N.; Baumer, B.; Kogias, E.; Werres, A.; Bette, S.; Saavedra, J. E.; Keefer, L. K.; Papazoglou, A.
  3. Neurosurgery. 2012, Feb; 70(2): 497-510.
  1. 6.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 7.   Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism
  2. Soria, J. A.; Arroyo, D. S.; Gaviglio, E. A.; Rodriguez-Galan, M. C.; Wang, J. M.; Iribarren, P.
  3. Neurobiology of Disease. 2011, Sep; 43(3): 616-624.
  1. 8.   Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative
  2. Tebbenkamp, A. T. N.; Green, C.; Xu, G. L.; Denovan-Wright, E. M.; Rising, A. C.; Fromholt, S. E.; Brown, H. H.; Swing, D.; Mandel, R. J.; Tessarollo, L.; Borchelt, D. R.
  3. Human Molecular Genetics. 2011, Jul; 20(14): 2770-2782.
  1. 9.   Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1 beta Activation and Severe Autoinflammation in Mice
  2. Chae, J. J.; Cho, Y. H.; Lee, G. S.; Cheng, J.; Liu, P. P.; Feigenbaum, L.; Katz, S. I.; Kastner, D. L.
  3. Immunity. 2011, May; 34(5): 755-768.
  1. 10.   Oligomer procyanidins from grape seeds induce a paraptosis-like programmed cell death in human glioblastoma U-87 cells
  2. Zhang, F. J.; Yang, J. Y.; Mou, Y. H.; Sun, B. S.; Wang, J. M.; Wu, C. F.
  3. Pharmaceutical Biology. 2010, Aug; 48(8): 883-890.
  1. 11.   Substituted E-3-(3-Indolylmethylene)-1,3-dihydroindo1-2-ones with Antitumor Activity. In Depth Study of the Effect on Growth of Breast Cancer Cells
  2. Andreani, A.; Bellini, S.; Burnelli, S.; Granaiola, M.; Leoni, A.; Locatelli, A.; Morigi, R.; Rambaldi, M.; Varoli, L.; Calonghi, N.; Cappadone, C.; Zini, M.; Stefanelli, C.; Masotti, L.; Shoemaker, R. H.
  3. Journal of Medicinal Chemistry. 2010, Aug; 53(15): 5567-5575.
  1. 12.   Synthesis and in vitro Evaluation of 3H-Pyrrolo[3,2-f]quinolin-9-one Derivatives That Show Potent and Selective Anti-leukemic Activity
  2. Ferlin, M. G.; Bortolozzi, R.; Brun, P.; Castagliuolo, I.; Hamel, E.; Basso, G.; Viola, G.
  3. Chemmedchem. 2010, Jul; 5(8): 1373-1385.
  1. 13.   Caspase polymorphisms and genetic susceptibility to multiple myeloma
  2. Hosgood, H. D.; Baris, D.; Zhang, Y.; Zhu, Y.; Zheng, T.; Yeager, M.; Welch, R.; Zahm, S.; Chanock, S.; Rothman, N.; Lan, Q.
  3. Hematological Oncology. 2008 26(3): 148-151.
  1. 14.   Interaction of a cyclic, bivalent Smac mimetic with the X-linked inhibitor of apoptosis protein
  2. Nikolovska-Coleska, Z.; Meagher, J. L.; Jiang, S.; Yang, C. Y.; Qiu, S.; Roller, P. P.; Stuckey, J. A.; Wang, S.
  3. Biochemistry. 2008 47(37): 9811-9824.
  1. 15.   The CD95 receptor: Apoptosis revisited
  2. Peter, M. E.; Budd, R. C.; Desbarats, J.; Hedrick, S. M.; Hueber, A. O.; Newell, M. K.; Owen, L. B.; Tschopp, J.; Wajant, H.; Wallach, D.; Wiltrout, R. H.; Zornig, M.; Lynch, D. H.
  3. Cell. 2007, May; 129(3): 447-450.
  1. 16.   JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells
  2. Udupi, V.; Yu, M.; Malaviya, S.; Saavedra, J. E.; Shami, P. J.
  3. Leukemia Research. 2006, Oct; 30(10): 1279-1283.
  1. 17.   Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis
  2. Malet, G.; Martin, A. G.; Orzaez, M.; Vicent, M. J.; Masip, I.; Sanclimens, G.; Ferrer-Montiel, A.; Mingarro, I.; Messeguer, A.; O Fearnhead, H.; Perez-Paya, E.
  3. Cell Death and Differentiation. 2006, Sep; 13(9): 1523-1532.
  1. 18.   Intracellular nucleotides act as critical prosurvival factors by binding to cyctochrome c and inhibiting apoptosome
  2. Chandra, D.; Bratton, S. B.; Person, M. D.; Tian, Y. A.; Martin, A. G.; Ayres, M.; Fearnhead, H. O.; Gandhi, V.; Tang, D. G.
  3. Cell. 2006, Jun; 125(7): 1333-1346.
  1. 19.   Inhibition of transcription factor NF-kappa B signaling proteins IKK beta and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity
  2. Liang, M. C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A.; Gilmore, T. D.
  3. Biochemical Pharmacology. 2006, FEB 28; 71(5): 634-645.
  1. 20.   IL-3-mediated TNF production is necessary for mast cell development
  2. Wright, H. V.; Bailey, D.; Kashyap, M.; Kepley, C. L.; Drutskaya, M. S.; Nedospasov, S. A.; Ryan, J. J.
  3. Journal of Immunology. 2006, FEB 15; 176(4): 2114-2121.
  1. 21.   CB694, a novel antimitotic with antitumor activities
  2. Weiderhold, K. N.; Randall-Hiubek, D. A.; Polin, L. A.; Hamel, E.; Mooberry, S. L
  3. International Journal of Cancer. 2006, FEB 15; 118(4): 1032-1040.
  1. 22.   Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin
  2. Tanaka, Y.; Igarashi, S.; Nakamura, M.; Gafni, J.; Torcassi, C.; Schilling, G.; Crippen, D.; Wood, J. D.; Sawa, A.; Jenkins, N. A.; Copeland, N. G.; Borchelt, D. R.; Ross, C. A.; Ellerby, L. M.
  3. Neurobiology of Disease. 2006, FEB; 21(2): 381-391.
  1. 23.   Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma
  2. Khan, T.; Hixon, J. A.; Stauffer, J. K.; Lincoln, E.; Back, T. C.; Brenner, J.; Lockett, S.; Nagashima, K.; Powell, D.; Wigginton, J. M.
  3. Journal of the National Cancer Institute. 2006, FEB 1; 98(3): 190-202.
  1. 24.   HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir
  2. Garg, H.; Blumenthal, R.
  3. Journal of Leukocyte Biology. 2006, Feb; 79(2): 351-362.
  1. 25.   Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
  2. Martin, L. J.; Pan, Y.; Price, A. C.; Sterling, W.; Copeland, N. G.; Jenkins, N. A.; Price, D. L.; Lee, M. K.
  3. Journal of Neuroscience. 2006, JAN 4; 26(1): 41-50.
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