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  1. 1.   Virtual screening for small-molecule pathway regulators by image-profile matching
  2. Rohban, Mohammad H; Fuller, Ashley M; Tan, Ceryl; Goldstein, Jonathan T; Syangtan, Deepsing; Gutnick, Amos; DeVine, Ann; Nijsure, Madhura P; Rigby,Megan; Sacher, Joshua R; Corsello, Steven M; Peppler, Grace B; Bogaczynska, Marta; Boghossian, Andrew; Ciotti, Gabrielle E; Hands, Allison T; Mekareeya, Aroonroj; Doan, Minh; Gale, Jennifer P; Derynck, Rik; Turbyville,Tommy; Boerckel, Joel D; Singh, Shantanu; Kiessling, Laura L; Schwarz, Thomas L; Varelas, Xaralabos; Wagner, Florence F; Kafri, Ran; Eisinger-Mathason, T S Karin; Carpenter, Anne E
  3. Cell Systems. 2022, Sep 01; 13(9): 724-736.e9.
  1. 2.   Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer
  2. Medina, Scott H; Bush, Brian; Cam, Maggie; Sevcik, Emily; DelRio, Frank W; Nandy, Kaustav; Schneider, Joel
  3. Biomaterials. 2019, May; 202: 1-11.
  1. 3.   Predicting tumor cell line response to drug pairs with deep learning
  2. Xia, Fangfang; Shukla, Maulik; Brettin, Thomas; Garcia-Cardona, Cristina; Cohn, Judith; Allen, Jonathan E.; Maslov, Sergei; Holbeck, Susan L.; Doroshow, Jim; Evrard, Yvonne; Stahlberg, Eric; Stevens, Rick L.
  3. BMC bioinformatics. 2018, Dec 21; 19(Supp 18):
  1. 4.   Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability
  2. Houliston, R Scott; Lemak, Alexander; Iqbal, Aman; Ivanochko, Danton; Duan, Shili; Kaustov, Lilia; Ong, Michelle S; Fan, Lixin; Senisterra, Guillermo; Brown, Peter J; Wang, Yun-Xing; Arrowsmith, Cheryl H
  3. Journal of Biological Chemistry. 2017, Dec 22; 292(51): 20947-20959.
  1. 5.   Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer.
  2. Chen, Ina; Mathews-Greiner, Lesley; Li, Dandan; Abisoye-Ogunniyan, Abisola; Ray, Satyajit; Bian, Yansong; Shukla, Vivek; Zhang, Xiaohu; Guha, Raj; Thomas, Craig; Gryder, Berkley; Zacharia, Athina; Beane, Joal D; Ravichandran, Sarangan; Ferrer, Marc; Rudloff, Udo
  3. Journal of translational medicine. 2017, May 01; 15(1): 92.
  1. 6.   Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii
  2. Klausmeyer, P.; Zhou, Q.; Scudiero, D. A.; Uranchimeg, B.; Melillo, G.; Cardellina, J. H.; Shoemaker, R. H.; Chang, C. J.; McCloud, T. G.
  3. Journal of Natural Products. 2009, May 22; 72(5): 805-12.
  1. 7.   Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa
  2. Meragelman, T. L.; Scudiero, D. A.; Davis, R. E.; Staudt, L. M.; McCloud, T. G.; Cardellina, J. H. 2nd.; Shoemaker, R. H.
  3. Journal of Natural Products. 2009, Mar 27; 72(3): 336-9.
  1. 8.   Development of a cell-based assay to quantify the inflammatory potential of test substances and screen compound libraries for anti-cancer drug candidates in a high-throughput format
  2. Kozlov, S. V.
  3. Methods in molecular biology (Clifton, N.J.). 2009 512: 159-167.
  1. 9.   DNA fingerprinting of the NCI-60 cell line panel
  2. Lorenzi, P. L.; Reinhold, W. C.; Varma, S.; Hutchinson, A. A.; Pommier, Y.; Chanock, S. J.; Weinstein, J. N.
  3. Molecular Cancer Therapeutics. 2009 8(4): 713-724.
  1. 10.   Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
  2. Gills, J.; Lo Piccolo, J.; Tsurutani, J.; Shoemaker, R. H.; Best, C. J. M.; Abu-Asab, M. S.; Borojerdi, J.; Warfel, N. A.; Gardner, E. R.; Danish, M.; Hollander, M. C.; Kawabata, S.; Tsokos, M.; Figga, W. D.; Steeg, P. S.; Dennis, P. A.
  3. Clinical Cancer Research. 2007, Sep; 13(17): 5183-5194.
  1. 11.   Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
  2. Shankavaram, U. T.; Reinhold, W. C.; Nishizuka, S.; Major, S.; Morita, D.; Chary, K. K.; Reimers, M. A.; Scherf, U.; Kahn, A.; Dolginow, D.; Cossman, J.; Kaldjian, E. P.; Scudiero, D. A.; Petricoin, E.; Liotta, L.; Lee, J. K.; Weinstein, J. N.
  3. Molecular Cancer Therapeutics. 2007, Mar; 6(3): 820-832.
  1. 12.   Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
  2. Reinhold, W. C.; Reimers, M. A.; Maunakea, A. K.; Kim, S.; Lababidi, S.; Scherf, U.; Shankavaram, U. T.; Ziegler, M. S.; Stewart, C.; Kouros-Mehr, H.; Cui, H. M.; Dolginow, D.; Scudiero, D. A.; Pommier, Y. G.; Munroe, D. J.; Feinberg, A. P.; Weinstein, J. N.
  3. Molecular Cancer Therapeutics. 2007, Feb; 6(2): 391-403.
  1. 13.   Crinamine from Crinum asiaticum var.japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2
  2. Kim, Y. H.; Park, E. J.; Park, M. H.; Badarch, U.; Woldemichael, G. M.; Beutler, J. A.
  3. Biological & Pharmaceutical Bulletin. 2006, Oct; 29(10): 2140-2142.
  1. 14.   Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt
  2. Gills, J. J.; Holbeck, S.; Hollingshead, M.; Hewitt, S. M.; Kozikowski, A. P.; Dennis, P. A.
  3. Molecular Cancer Therapeutics. 2006, Mar; 5(3): 713-722.
  1. 15.   In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative
  2. Hollingshead, M.; Alley, M.; Burger, A. M.; Borgel, S.; Pacula-Cox, C.; Fiebig, H. H.; Sausville, E. A.
  3. Cancer Chemotherapy and Pharmacology. 2005, AUG; 56(2): 115-125.
  1. 16.   Cytotoxicity of RH1: NAD(P)H : quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction
  2. Tudor, G.; Alley, M.; Nelson, C. M.; Huang, R. L.; Covell, D. G.; Gutierrez, P.; Sausville, E. A.
  3. Anti-Cancer Drugs. 2005 16(4): 381-391.
  1. 17.   Fluorinated 2-(4-amino-3-methylphenyl) benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells
  2. Brantley, E.; Trapani, V.; Alley, M. C.; Hose, C. D.; Bradshaw, T. D.; Stevens, M. F. G.; Sausville, E. A.; Stinson, S. F.
  3. Drug Metabolism and Disposition. 2004, DEC; 32(12): 1392-1401.
  1. 18.   The hollow fibre model in cancer drug screening: the NCI experience
  2. Decker, S.; Hollingshead, M.; Bonomi, C. A.; Carter, J. P.; Sausville, E. A.
  3. European Journal of Cancer. 2004 40(6): 821-826.
  1. 19.   Aryl hydrocarbon receptor activation of an antitumor aminoflavone: Basis of selective toxicity for MCF-7 breast tumor cells
  2. Loaiza-Perez, A. I.; Kenney, S.; Boswell, J.; Hollingshead, M.; Alley, M. C.; Hose, C.; Ciolino, H. P.; Yeh, G. C.; Trepel, J. B.; Vistica, D. T.; Sausville, E. A.
  3. Molecular Cancer Therapeutics. 2004 3(6): 715-725.
  1. 20.   RNA cleavage and inhibition of protein synthesis by bleomycin
  2. Abraham, A. T.; Lin, J. J.; Newton, D. L.; Rybak, S.; Hecht, S. M.
  3. Chemistry & Biology. 2003 10(1): 45-52.
  1. 21.   Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4- amino-3-methylphenyl]-5-fluoro-benzothiazole: A potential surrogate marker for patient sensitivity
  2. Hose, C. D.; Hollingshead, M.; Sausville, E. A.; Monks, A.
  3. Molecular Cancer Therapeutics. 2003 2(12): 1265-1272.
  1. 22.   Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase
  2. Koo, H. M.; Vanbrocklin, M.; McWilliams, M. J.; Leppla, S. H.; Duesbery, N. S.; Vande Woude, G. F.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2002 99(5): 3052-3057.
  1. 23.   Mining the National Cancer Institute's tumor-screening database: Identification of compounds with similar cellular activities
  2. Rabow, A. A.; Shoemaker, R. H.; Sausville, E. A.; Covell, D. G.
  3. Journal of Medicinal Chemistry. 2002 45(4): 818-840.
  1. 24.   P450 enzyme expression patterns in the NCI human tumor cell line panel
  2. Yu, L. J.; Matias, J.; Scudiero, D. A.; Hite, K. M.; Monks, A.; Sausville, E. A.; Waxman, D. J.
  3. Drug Metabolism and Disposition. 2001 29(3): 304-312.
  1. 25.   Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
  2. Taverna, P.; Liu, L.; Hanson, A. J.; Monks, A.; Gerson, S. L.
  3. Cancer Chemotherapy and Pharmacology. 2000 46(6): 507-516.
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