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  1. 1.   RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
  2. Smith,Russell; Terrell,Elizabeth; Insinna, Christine; Agamasu, Constance; Wagner, Morgan E; Ritt,Daniel; Stauffer,Jimmy; Stephen,Andy; Morrison,Deborah
  3. Molecular Cell. 2022, Nov 17; 82(22): 4262-4276.
  1. 2.   The mechanism of Raf activation through dimerization
  2. Zhang,Mingzhen; Maloney,Ryan; Jang,Hyunbum; Nussinov,Ruth
  3. Chemical Science. 2021, Dec 08; 12(47): 15609-15619.
  1. 3.   B-Raf autoinhibition in the presence and absence of 14-3-3
  2. Zhang,Mingzhen; Jang,Hyunbum; Li, Zhigang; Sacks, David B.; Nussinov,Ruth
  3. Structure. 2021, Jul 1; 29(7): 768-777.e2.
  1. 4.   The Structural Basis of Akt PH Domain Interaction with Calmodulin
  2. Weako,Jackson; Jang, Hyunbum; Keskin, Ozlem; Nussinov,Ruth; Gursoy, Attila
  3. Biophysical Journal. 2021, May 18; 120(10): 1994-2008.
  1. 5.   Inhibition of Nonfunctional Ras
  2. Nussinov,Ruth; Jang, Hyunbum; Gursoy, Attila; Keskin, Ozlem; Gaponenko, Vadim
  3. Cell Chemical Biology. 2021, Feb 18; 28(2): 121-133.
  1. 6.   Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD
  2. Travers, Timothy; López, Cesar A; Agamasu, Constance; Hettige, Jeevapani J; Messing,Simon; García, Angel E; Stephen, Andrew G; Gnanakaran, S
  3. Biophysical journal. 2020, AUG 4; 119(3): 525-538.
  1. 7.   The Mystery of Rap1 Suppression of Oncogenic Ras
  2. Nussinov,Ruth; Jang,Hyunbum; Zhang,Mingzhen; Tsai,Chung-Jung; Sablina, Anna A.
  3. Trends in cancer. 2020, May; 6(5): 369-379.
  1. 8.   Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes
  2. Zemskov, E. A.; Mikhailenko, I.; Hsia, R. C.; Zaritskaya, L.; Belkin, A. M.
  3. Plos One. 2011, Apr; 6(4): 14.
  1. 9.   The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
  2. Abram, M. E.; Sarafianos, S. G.; Parniak, M. A.
  3. Retrovirology. 2010, Feb; 7: 9.
  1. 10.   Subtype-Specific Differences in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Connection Subdomain of CRF01_AE Are Associated with Higher Levels of Resistance to 3 '-Azido-3 '-Deoxythymidine
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Maldarelli, F.; Hase, S.; Takebe, Y.; Pathak, V. K.
  3. Journal of Virology. 2009 83(17): 8502-8513.
  1. 11.   Structure of ERA in complex with the 3 ' end of 16S rRNA: Implications for ribosome biogenesis
  2. Tu, C.; Zhou, X. M.; Tropea, J. E.; Austin, B. P.; Waugh, D. S.; Court, D. L.; Ji, X. H.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009 106(35): 14843-14848.
  1. 12.   Synthesis, processing, and composition of the virion-associated HTLV-1 reverse transcriptase
  2. Mitchell, M. S.; Tozser, J.; Princler, G.; Lloyd, P. A.; Auth, A.; Derse, D.
  3. Journal of Biological Chemistry. 2006, FEB 17; 281(7): 3964-3971.
  1. 13.   Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms
  2. Grivennikov, S. I.; Kuprash, D. V.; Liu, Z. G.; Nedospasov, S. A.
  3. International Review of Cytology - a Survey of Cell Biology, Vol 252. 2006; 252 : 129-+.
  1. 14.   Reduction of the antiapoptotic protein cFLIP enhances the susceptibility of human renal cancer cells to TRAIL apoptosis
  2. Brooks, A. D.; Sayers, T. J.
  3. Cancer Immunology Immunotherapy. 2005, MAY; 54(5): 499-505.
  1. 15.   Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
  2. Nikolenko, G. N.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, FEB 8; 102(6): 2093-2098.
  1. 16.   Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins
  2. Ivanova, A. V.; Ivanov, S. V.; Lerman, M. L.
  3. Cellular and Molecular Life Sciences. 2005, FEB; 62(4): 471-484.
  1. 17.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 18.   RNase H domains obtained from treatment-experienced patients increase resistance to AZT
  2. Nikolenko, G. N.; Frankenberry, K. A.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Antiviral Therapy. 2005 10(4): S89-S89.
  1. 19.   Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase
  2. Bibillo, A.; Lener, D.; Klarmann, G. J.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(1): 171-181.
  1. 20.   Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
  2. Julias, J. G.; McWilliams, M. J.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, DEC; 78(23): 13315-13324.
  1. 21.   Mutations in HIV-1 RNase H domain confer high-level resistance to nucleoside reverse transcriptase inhibitors and provide novel insights into the mechanism of nucleotide excision-mediated drug resistance
  2. Nikolenko, G. N.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Antiviral Therapy. 2004, AUG; 9(4): U35-U36.
  1. 22.   Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(3): 644-655.
  1. 23.   Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase
  2. Boyer, P. L.; Stenbak, C. R.; Clark, P. K.; Linial, M. L.; Hughes, S. H.
  3. Journal of Virology. 2004 78(12): 6112-6121.
  1. 24.   Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase
  2. Lener, D.; Kvaratskhelia, M.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2003 278(29): 26526-26532.
  1. 25.   Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase
  2. Kvaratskhelia, M.; Budihas, S. R.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2002 277(19): 16689-16696.
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