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  1. 1.   Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors
  2. Tirosh, Amit; Mukherjee, Sanjit; Lack, Justin; Gara, Sudheer Kumar; Wang, Sophie; Quezado, Martha M; Keutgen, Xavier M; Wu, Xiaolin; Cam, Maggie; Kumar, Suresh; Patel, Dhaval; Nilubol, Naris; Tyagi, Monica Varun; Kebebew, Electron
  3. Cancer. 2019, Apr 15; 125(8): 1247-1257.
  1. 2.   Genetic predisposition to kidney cancer
  2. Schmidt, Laura; Linehan, W. Marston
  3. SEMINARS IN ONCOLOGY. 2016, Oct; 43(5): 566-574.
  1. 3.   RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
  2. Lipkowitz, S.; Weissman, A. M.
  3. Nature Reviews Cancer. 2011, Sep; 11(9): 629-643.
  1. 4.   Molecular Diagnosis and Therapy of Kidney Cancer
  2. Linehan, W. M.; Bratslavsky, G.; Pinto, P. A.; Schmidt, L. S.; Neckers, L.; Bottaro, D. P.; Srinivasan, R.
  3. Annual Review of Medicine. 2010, Feb; 61: 329-343.
  1. 5.   Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours
  2. Ivanova, A. V.; Vortmeyer, A.; Ivanov, S. V.; Nickerson, M. L.; Maher, E. R.; Lerman, M. I.
  3. Journal of Pathology. 2008 214(1): 46-57.
  1. 6.   Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design
  2. Liu, J.; Nussinov, R.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2008 105(3): 901-906.
  1. 7.   Identification of the genes for kidney cancer: Opportunity for disease-specific targeted therapeutics
  2. Linehan, W. M.; Pinto, P. A.; Srinivasan, R.; Merino, M.; Choyke, P.; Choyke, L.; Coleman, J.; Toro, J.; Glenn, G.; Vocke, C.; Zbar, B.; Schmidt, L. S.; Bottaro, D.; Neckers, L.
  3. Clinical Cancer Research. 2007, Jan; 13(2): 671S-679S.
  1. 8.   Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression
  2. Woldemichael, G. M.; Vasselli, J. R.; Gardella, R. S.; McKee, T. C.; Linehan, W. M.; McMahon, J. B.
  3. Journal of Biomolecular Screening. 2006, Sep; 11(6): 678-687.
  1. 9.   Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis
  2. Hong, S. B.; Furihata, M.; Baba, M.; Zbar, B.; Schmidt, L. S.
  3. Laboratory Investigation. 2006, Jul; 86(7): 664-675.
  1. 10.   Expression of hypoxia-inducible carbonic anhydrases in brain tumors
  2. Proescholdt, M. A.; Mayer, C.; Kubitza, M.; Schubert, T.; Liao, S. Y.; Stanbridge, E. J.; Ivanov, S.; Oldfield, E. H.; Brawanski, A.; Merrill, M. J.
  3. Neuro-Oncology. 2005, OCT; 7(4): 465-475.
  1. 11.   Topotecan blocks hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
  2. Beppu, Y.; Nakamura, K.; Linehan, W. M.; Rapisarda, A.; Thiele, C. J.
  3. Cancer Research. 2005, JUN 1; 65(11): 4775-4781.
  1. 12.   Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
  2. Salnikow, K.; Donald, S. P.; Bruick, R. K.; Zhitkovich, A.; Phang, J. M.; Kasprzak, K. S.
  3. Journal of Biological Chemistry. 2004, SEP 24; 279(39): 40337-40344.
  1. 13.   Genetic basis of cancer of the kidney: Disease specific approaches to therapy
  2. Linehan, W. M.; Vasselli, J.; Srinivasan, R.; Walther, M. M.; Merino, M.; Choyke, P.; Vocke, C.; Schmidt, L.; Isaacs, J. S.; Glenn, G.; Toro, J.; Zbar, B.; Bottaro, D.; Neckers, L.
  3. Clinical Cancer Research. 2004, SEP 15; 10(18, Part 2 Suppl. S): 6282S-6289S.
  1. 14.   Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location
  2. Maranchie, J. K.; Afonso, A.; Albert, P. S.; Kalyandrug, S.; Phillips, J. L.; Zhou, S.; Peterson, J.; Ghadimi, B. M.; Hurley, K.; Riss, J.; Vasselli, J. R.; Ried, T.; Zbar, B.; Choyke, P.; Walther, M. M.; Klausner, R. D.; Linehan, W. M.
  3. Human Mutation. 2004 23(1): 40-46.
  1. 15.   HIF-1 - An oxygen and metal responsive transcription factor
  2. Maxwell, P.; Salnikow, K.
  3. Cancer Biology & Therapy. 2004 3(1): 29-35.
  1. 16.   The von Hippel-Lindau gene and protein in tumorigenesis and angiogenesis: A potential target for therapeutic designs
  2. Shiao, Y. H.
  3. Current Medicinal Chemistry. 2003 10(22): 2461-2470.
  1. 17.   VHL down-regulation and differential localization as mechanisms in tumorigenesis
  2. Shiao, Y. H.; Forsti, A.; Egevad, L.; Anderson, L. M.; Lindblad, P.; Hemminki, K.
  3. Kidney International. 2003 64(5): 1671-1674.
  1. 18.   Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene
  2. Ma, W. B.; Tessarollo, L.; Hong, S. B.; Baba, M.; Southon, E.; Back, T. C.; Spence, S.; Lobe, C. G.; Sharma, N.; Maher, G. W.; Pack, S.; Vortmeyer, A. O.; Guo, C. F.; Zbar, B.; Schmidt, L. S.
  3. Cancer Research. 2003 63(17): 5320-5328.
  1. 19.   Studying cancer families to identify kidney cancer genes
  2. Zbar, B.; Klausner, R.; Linehan, W. M.
  3. Annual Review of Medicine-Selected Topics in the Clinical Sciences. 2003 54: 217-233.
  1. 20.   The genetic basis of renal cell carcinoma
  2. Pavlovich, C. P.; Schmidt, L. S.; Phillips, J. L.
  3. Urologic Clinics of North America. 2003 30(3): 437-+.
  1. 21.   Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors
  2. Shiao, Y. H.; Kamata, S. I.; Li, L. M.; Hooth, M. J.; DeAngelo, A. B.; Anderson, L. M.; Wolf, D. C.
  3. Cancer Letters. 2002 187(1-2): 207-214.
  1. 22.   Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors
  2. Shiao, Y. H.; Ramakrishna, G.; Anderson, L. M.; Perantoni, A. O.; Rice, J. M.; Diwan, B. A.
  3. Cancer Letters. 2002 179(1): 33-38.
  1. 23.   VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
  2. Brauch, H.; Weirich, G.; Brieger, J.; Glavac, D.; Rodl, H.; Eichinger, M.; Feurer, M.; Weidt, E.; Puranakanitstha, C.; Neuhaus, C.; Pomer, S.; Brenner, W.; Schirmacher, P.; Storkel, S.; Rotter, M.; Masera, A.; Gugeler, N.; Decker, H. J.
  3. Cancer Research. 2000 60(7): 1942-1948.
  1. 24.   The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes
  2. Lerman, M. I.; Minna, J. D.
  3. Cancer Research. 2000 60(21): 6116-6133.
  1. 25.   Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: Comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma
  2. Walther, M. M.; Reiter, R.; Keiser, H. R.; Choyke, P. L.; Venzon, D.; Hurley, K.; Gnarra, J. R.; Reynolds, J. C.; Glenn, G. M.; Zbar, B.; Linehan, W. M.
  3. Journal of Urology. 1999 162(3 Part 1): 659-664.
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