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  1. 1.   Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1ß axes bridge innate immunity and epithelial apoptosis to promote emphysema
  2. Ruwanpura, Saleela M; McLeod, Louise; Dousha, Lovisa F; Seow, Huei J; West, Alison C; West, Alice J; Weng, Teresa; Alanazi, Mohammad; MacDonald, Martin; King, Paul T; Bardin, Philip G; Gabay, Cem; Klinman, Dennis M; Bozinovski, Steven; Vlahos, Ross; Anderson, Gary P; Rose-John, Stefan; Saad, Mohamed I; Jenkins, Brendan J
  3. Proceedings of the National Academy of Sciences of the United States of America. 2022, Sep 06; 119(36): e2201494119.
  1. 2.   Tocilizumab in patients with symptomatic Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
  2. Ramaswami, Ramya; Lurain, Kathryn; Peer, Cody J.; Serquina, Anna; Wang, Victoria; Widell, Anaida; Goncalves, Priscila; Steinberg, Seth M.; Marshall,Vickie; George, Jomy; Figg, William D.; Whitby,Denise; Ziegelbauer, Joseph; Uldrick, Thomas S.; Yarchoan, Robert
  3. BLOOD. 2020, JUN 18; 135(25): 2316-2319.
  1. 3.   Initiation of antiretroviral therapy in early HIV infection reduces but does not abrogate chronic residual inflammation
  2. Sereti, I.; Krebs, S. J.; Phanuphak, N.; Fletcher, J. L.; Slike, B.; Pinyakorn, S.; O'Connell, R. J.; Rupert, Adam; Chomont, N.; Valcour, V.; Kim, J. H.; Robb, M. L.; Michael, N. L.; Douek, D. C.; Ananworanich, J.; Utay, N. S.
  3. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017, Jan 15; 64(2): 124-131.
  1. 4.   Nitric oxide is a key component in inflammation-accelerated tumorigenesis
  2. Hussain, S. P.; He, P.; Subleski, J.; Hofseth, L. J.; Trivers, G. E.; Mechanic, L.; Hofseth, A. B.; Bernard, M.; Schwank, J.; Nguyen, G.; Mathe, E.; Djurickovic, D.; Haines, D.; Weiss, J.; Back, T.; Gruys, E.; Laubach, V. E.; Wiltrout, R. H.
  3. Cancer Research. 2008 68(17): 7130-7136.
  1. 5.   Differential roles of C/EBP beta regulatory domains in specifviuy MCP-1 and IL-6 transcription
  2. Spooner, C. J.; Guo, X. R.; Johnson, P. F.; Schwartz, R. C.
  3. Molecular Immunology. 2007, Feb; 44(6): 1384-1392.
  1. 6.   C/EBP beta serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription
  2. Spooner, C. J.; Sebastian, T.; Shuman, J. D.; Durairaj, S.; Guo, X. R.; Johnson, P. F.; Schwartz, R. C.
  3. Cytokine. 2007, Feb; 37(2): 119-127.
  1. 7.   Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients
  2. Zhang, L.; Kao, W. H. L.; Berthier-Schaad, Y.; Liu, Y.; Plantinga, L.; Jaar, B. G.; Fink, N.; Powe, N.; Klag, M. J.; Smith, M. W.; Coresh, J.
  3. Journal of the American Society of Nephrology. 2006, Aug; 17(8): 2285-2292.
  1. 8.   Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
  2. Kim, B. G.; Li, C. L.; Qiao, W. H.; Mamura, M.; Kasperczak, B.; Anver, M.; Wolfraim, L.; Hong, S.; Mushinski, E.; Potter, M.; Kim, S. J.; Fu, X. Y.; Deng, C. X.; Letterio, J. J.
  3. Nature. 2006, Jun; 441(7096): 1015-1019.
  1. 9.   Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation
  2. Nunez, N. P.; Oh, W. J.; Rozenberg, J.; Perella, C.; Anver, M.; Barrett, J. C.; Perkins, S. N.; Berrigan, D.; Moitra, J.; Varticovski, L.; Hursting, S. D.; Vinson, C.
  3. Cancer Research. 2006, MAY 15; 66(10): 5469-5476.
  1. 10.   Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
  2. Fuss, I. J.; Becker, C.; Yang, Z. Q.; Groden, C.; Hornung, R. L.; Heller, F.; Neurath, M. F.; Strober, W.; Mannon, P. J.
  3. Inflammatory Bowel Diseases. 2006, JAN; 12(1): 9-15.
  1. 11.   A transcription inhibitor, Actinomycin D, enhances HIV-1 replication through an interleukin-6-dependent pathway
  2. Imamichi, T.; Conrads, T. P.; Zhou, M.; Liu, Y. X.; Adelsberger, J. W.; Veenstra, T. D.; Lane, H. C.
  3. Jaids-Journal of Acquired Immune Deficiency Syndromes. 2005, DEC 1; 40(4): 388-397.
  1. 12.   Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity
  2. Sun, K.; Wilkins, D. E. C.; Anver, M. R.; Sayers, T. J.; Panoskaltsis-Mortari, A.; Blazar, B. R.; Weiniak, L. A.; Murphy, W. J.
  3. Blood. 2005, NOV 1; 106(9): 3293-3299.
  1. 13.   The role of IL-6 and STAT3 in inflammation and cancer
  2. Hodge, D. R.; Hurt, E. M.; Farrar, W. L.
  3. European Journal of Cancer. 2005, NOV; 41(16): 2502-2512.
  1. 14.   Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity
  2. Carlos, C. A.; Dong, H. F.; Howard, O. M. Z.; Oppenheim, J. J.; Hanisch, F. G.; Finn, O. J.
  3. Journal of Immunology. 2005, AUG 1; 175(3): 1628-1635.
  1. 15.   Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE(2) and TGF-beta(1)
  2. Ha, C. T.; Waterhouse, R.; Wessells, J.; Wu, J. A.; Dveksler, G. S.
  3. Journal of Leukocyte Biology. 2005, JUN; 77(6): 948-957.
  1. 16.   Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
  2. Hodge, D. R.; Peng, B.; Cherry, J. C.; Hurt, E. M.; Fox, S. D.; Kelley, J. A.; Munroe, D. J.; Farrar, W. L.
  3. Cancer Research. 2005, JUN 1; 65(11): 4673-4682.
  1. 17.   HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood
  2. Pinto, L. A.; Castle, P. E.; Roden, R. B.; Harro, C. D.; Lowy, D. R.; Schiller, J. T.; Wallace, D.; Williams, M.; Kopp, W.; Frazer, I. H.; Berzofsky, J. A.; Hildesheim, A.
  3. Vaccine. 2005, MAY 20; 23(27): 3555-3564.
  1. 18.   Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
  2. Hodge, D. R.; Peng, B.; Pompeia, C.; Thomas, S.; Cho, E.; Clausen, P. A.; Marquez, V. E.; Farrar, W. L.
  3. Cancer Biology & Therapy. 2005, May; 4(5): 585-592.
  1. 19.   Dendritic cells endocytose Bacillus anthracis spores: Implications for anthrax pathogenesis
  2. Brittingham, K. C.; Ruthel, G.; Panchal, R. G.; Fuller, C. L.; Ribot, W. J.; Hoover, T. A.; Young, H. A.; Anderson, A. O.; Bavari, S.
  3. Journal of Immunology. 2005, MAY 1; 174(9): 5545-5552.
  1. 20.   Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
  2. Pengt, B.; Hodge, D. R.; Thomas, S. B.; Cherry, J. M.; Munroe, D. J.; Pompeia, C.; Xiao, W. H.; Farrar, W. L.
  3. Journal of Biological Chemistry. 2005, FEB 11; 280(6): 4182-4187.
  1. 21.   Endogenous leukemia inhibitory factor attenuates endotoxin response
  2. Weber, M. A.; Schnyder-Candrian, S.; Schnyder, B.; Quesniaux, V.; Poli, V.; Stewart, C. L.; Ryffel, B.
  3. Laboratory Investigation. 2005, FEB; 85(2): 276-284.
  1. 22.   The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappa B activity in drug-sensitive MCF-7 cells
  2. Brantley, E.; Patel, V.; Stinson, S. F.; Trapani, V.; Hose, C. D.; Ciolino, H. P.; Yeh, G. C.; Gutkind, J. S.; Sausville, E. A.; Loaiza-Perez, A. I.
  3. Anti-Cancer Drugs. 2005, FEB; 16(2): 137-143.
  1. 23.   Nuclear receptors as negative modulators of STAT3 in multiple myeloma
  2. Wang, L. H.; Yang, X. Y.; Zhang, X. H.; Farrar, W. L.
  3. Cell Cycle. 2005, FEB; 4(2): 242-245.
  1. 24.   Co-operative functions between nuclear factors NF kappa B and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells
  2. Xiao, W. H.; Hodge, D. R.; Wang, L. H.; Yang, X. Y.; Zhang, X. H.; Farrar, W. L.
  3. Prostate. 2004, DEC 1; 61(4): 354-370.
  1. 25.   NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells
  2. Xiao, W. H.; Hodge, D. R.; Wang, L. H.; Yang, X. Y.; Zhang, X. H.; Farrar, W. L.
  3. Cancer Biology & Therapy. 2004, OCT; 3(10): 1007-1017.
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