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  1. 1.   In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines
  2. Behrsing, H. P.; Furniss, M. J.; Robillard, K. A.; Tomaszewski, J. E.; Parchment, R. E.
  3. Cancer Chemotherapy and Pharmacology. 2010, May; 65(6): 1083-1091.
  1. 2.   HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses
  2. Donovan, P. J.; Smith, G. T.; Dove, L. F.; Klose, J.; Powell, D. A.
  3. Birth Defects Research Part B-Developmental and Reproductive Toxicology. 2006, Oct; 77(5): 399-404.
  1. 3.   The mutagenic effects of 7,12-dimethylbenz[a]anthacene, 3-methylcholanthrene and benzo[a]pyrene to the developing Syrian hamster fetus measured by an in vivo/in vitro mutation assay
  2. Donovan, P. J.; Smith, G. T.; Nardone, R.
  3. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2004, OCT 4; 554(1-2): 111-120.
  1. 4.   DNA repair protein levels vis-a-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program
  2. Xu, Z. Y.; Chen, Z. P.; Malapetsa, A.; Alaoui-Jamali, M.; Bergeron, J.; Monks, A.; Myers, T. G.; Mohr, G.; Sausville, E. A.; Scudiero, D. A.; Aloyz, R.; Panasci, L. C.
  3. Anti-Cancer Drugs. 2002 13(5): 511-519.
  1. 5.   Both extraneuronal monoamine transporter and O-6-methylguanine- DNA methyltransferase expression influence the antitumor efficacy of 2-chloroethyl-3-sarcosinamide-1-nitrosourea in human tumor xenografts
  2. Chen, Z. P.; Wang, Z. M.; Carter, C. A.; Alley, M. C.; Mohr, G.; Panasci, L. C.
  3. Journal of Pharmacology and Experimental Therapeutics. 2001 296(3): 712-715.
  1. 6.   Phase I trial of carmustine plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
  2. Friedman, H. S.; Pluda, J.; Quinn, J. A.; Ewesuedo, R. B.; Long, L.; Friedman, A. H.; Cokgor, I.; Colvin, O. M.; Haglund, M. M.; Ashley, D. M.; Rich, J. N.; Sampson, J.; Pegg, A. E.; Moschel, R. C.; McLendon, R. E.; Provenzale, J. M.; Stewart, E. S.; Tourt-Uhlig, S.; Garcia-Turner, A. M.; Herndon, J. E.; Bigner, D. D.; Dolan, M. E.
  3. Journal of Clinical Oncology. 2000 18(20): 3522-3528.
  1. 7.   Plasma and cerebrospinal fluid pharmacokinetics of O-6- benzylguanine and analogues in nonhuman primates
  2. Long, L.; Berg, S. L.; Roy, S. K.; McCully, C. L.; Song-Yoo, H. W.; Moschel, R. C.; Balis, F. M.; Dolan, M. E.
  3. Clinical Cancer Research. 2000 6(9): 3662-3669.
  1. 8.   O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials
  2. Keir, S. T.; Dolan, M. E.; Pegg, A. E.; Lawless, A.; Moschel, R. C.; Bigner, D. D.; Friedman, H. S.
  3. Cancer Chemotherapy and Pharmacology. 2000 45(6): 437-440.
  1. 9.   Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism
  2. Kokkinakis, D. M.; Moschel, R. C.; Pegg, A. E.; Schold, S. C.
  3. Cancer Chemotherapy and Pharmacology. 2000 45(1): 69-77.
  1. 10.   Critical windows of exposure for children's health: Cancer in human epidemiological studies and neoplasms in experimental animal models
  2. Anderson, L. M.; Diwan, B. A.; Fear, N. T.; Roman, E.
  3. Environmental Health Perspectives. 2000 108(Suppl 3): 573-594.
  1. 11.   Cell sensitivity to transplacental carcinogenesis by N-ethyl-N-nitrosourea is greatest in early post-implantation development
  2. Donovan, P. J.
  3. Mutation Research - Fundamental & Molecular Mechanisms of Mutagenesis. 1999 427(1): 59-63.
  1. 12.   Cell sensitivity to transplacental mutagenesis by N-ethyl-N-nitrosourea is greatest during early gestation in the Syrian hamster
  2. Donovan, P. J.; Smith, G. T.
  3. Mutation Research - Fundamental & Molecular Mechanisms of Mutagenesis. 1999 427(1): 47-58.
  1. 13.   Selective Mutation of K-Ras By N-Ethylnitrosourea Shifts From Codon 12 to Codon 61 During Fetal Mouse Lung Maturation
  2. Sithanandam, G.; Ramakrishna, G.; Diwan, B. A.; Anderson, L. M.
  3. Oncogene. 1998 17(4): 493-502.
  1. 14.   O-6-Alkylguanine-Dna Alkyltransferase Inactivation By Ester Prodrugs of O-6-Benzylguanine Derivatives and Their Rate of Hydrolysis By Cellular Esterases
  2. Dolan, M. E.; Roy, S. K.; Garbiras, B. J.; Helft, P.; Paras, P.; Chae, M. Y.; Moschel, R. C.; Pegg, A. E.
  3. Biochemical Pharmacology. 1998 55(10): 1701-1709.
  1. 15.   Gestation stage- and carcinogen-specific K-ras mutations in mouse lung tumors initiated transplacentally
  2. Sithanandam, G.; Diwan, B. A.; Anderson, L. M.
  3. Annual Meeting of the American Association for Cancer Research. 1997, 38 A1896.
  1. 16.   Malignant transformation of human prostate epithelial cells by N-nitroso-N-methylurea
  2. Rhim, J.; Jin, S.; Jung, M.; Thraves, P.; Kuethel, M.; Webber, M.; Hukku, B.
  3. Annual Meeting of the American Association for Cancer Research. 1997, 38 A2494.
  1. 17.   Intraarterial O-6-Benzylguanine Enables the Specific Therapy of Nitrosourea-Resistant Intracranial Human Glioma Xenografts in Athymic Rats With 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
  2. Kurpad, S. N.; Dolan, M. E.; McLendon, R. E.; Archer, G. E.; Moschel, R. C.; Pegg, A. E.; Bigner, D. D.; Friedman, H. S.
  3. Cancer Chemotherapy and Pharmacology. 1997 39(4): 307-316.
  1. 18.   Tgf-Alpha Sustains Clonal Expansion By Promoter-Dependent, Chemically Initiated Rat Hepatocytes
  2. Kaufmann, W. K.; Byrd, L. L.; Palmieri, D.; Nims, R. W.; Rice, J. M.
  3. Carcinogenesis. 1997 18(7): 1381-1387.
  1. 19.   2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea Novel Chloroethylnitrosourea Analogue With Enhanced Antitumor Activity Against Human Glioma Xenografts
  2. Marcantonio, D.; Panasci, L. C.; Hollingshead, M. G.; Alley, M. C.; Camalier, R. F.; Sausville, E. A.; Dykes, D. J.; Carter, C. A.; Malspeis, L.
  3. Cancer Research. 1997 57(18): 3895-3898.
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