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  1. 1.   Genotypic Resistance at Viral Rebound Among Patients Who Received Lopinavir/Ritonavir-Based or Efavirenz-Based First Antiretroviral Therapy in South Africa
  2. Dlamini, J. N.; Hu, Z. H.; Ledwaba, J.; Morris, L.; Maldarelli, F. M.; Dewar, R. L.; Highbarger, H. C.; Somaroo, H.; Sangweni, P.; Follmann, D. A.; Pau, A. K.; Phidisa, I. I. S. T.
  3. Jaids-Journal of Acquired Immune Deficiency Syndromes. 2011, Nov; 58(3): 304-308.
  1. 2.   The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC
  2. Davis, C. A.; Parniak, M. A.; Hughes, S. H.
  3. Virology. 2011, Oct; 419(2): 64-71.
  1. 3.   Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine
  2. Boltz, V. F.; Zheng, Y.; Lockman, S.; Hong, F. Y.; Halvas, E. K.; McIntyre, J.; Currier, J. S.; Chibowa, M. C.; Kanyama, C.; Nair, A.; Owino-Ong'or, W.; Hughes, M.; Coffin, J. M.; Mellors, J. W.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2011, May; 108(22): 9202-9207.
  1. 4.   Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors
  2. Nikolenko, G. N.; Kotelkin, A. T.; Oreshkova, S. F.; Ilyichev, A. A.
  3. Molecular Biology. 2011, Feb; 45(1): 93-109.
  1. 5.   Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines (S-DACOs) as high active anti-HIV agents
  2. He, Y. P.; Long, J.; Zhang, S. S.; Li, C.; Lai, C. C.; Zhang, C. S.; Li, D. X.; Zhang, D. H.; Wang, H.; Cai, Q. Q.; Zheng, Y. T.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, Jan; 21(2): 694-697.
  1. 6.   The "Connection" Between HIV Drug Resistance and RNase H
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Pathak, V. K.
  3. Viruses-Basel. 2010, Jul; 2(7): 1476-1503.
  1. 7.   Analysis of amino acids in the beta 7-beta 8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication
  2. Mulky, A.; Vu, B. C.; Conway, J. A.; Hughes, S. H.; Kappes, J. C.
  3. Journal of Molecular Biology. 2007, Feb; 365(5): 1368-1378.
  1. 8.   Development of therapeutics for chronic HCV infection
  2. Huang, Z.; Murray, M. G.; Secrist, J. A.
  3. Antiviral Research. 2006, Sep; 71(2-3): 351-362.
  1. 9.   New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity
  2. Krajewski, K.; Zhang, Y. J.; Parrish, D.; Deschamps, J.; Roller, P. P.; Pathak, V. K.
  3. Bioorganic & Medicinal Chemistry Letters. 2006, Jun; 16(11): 3034-3038.
  1. 10.   HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
  2. Himmel, D. M.; Sarafianos, S. G.; Dharmasena, S.; Hossain, M. M.; McCoy-Simandle, K.; Ilina, T.; Clark, A. D.; Knight, J. L.; Julias, J. G.; Clark, P. K.; Krogh-Jespersen, K.; Levy, R. M.; Hughes, S. H.; Parniak, M. A.; Arnold, E.
  3. Acs Chemical Biology. 2006 1(11): 702-712.
  1. 11.   Chemical library screen for novel inhibitors of Kaposi's sarcoma-associated herpesvirus processive DNA synthesis
  2. Dorjsuren, D.; Burnette, A.; Gray, G. N.; Chen, X. L.; Zhu, W. M.; Roberts, P. E.; Currens, M. J.; Shoemaker, R. H.; Ricciardi, R. P.; Sei, S.
  3. Antiviral Research. 2006, JAN; 69(1): 9-23.
  1. 12.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 13.   Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants
  2. Nissley, D. V.; Halvas, E. K.; Hoppman, N. L.; Garfinkel, D. J.; Mellors, J. W.; Strathern, J. N.
  3. Journal of Clinical Microbiology. 2005, NOV; 43(11): 5696-5704.
  1. 14.   Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
  2. Das, K.; Lewi, P. J.; Hughes, S. H.; Arnold, E.
  3. Progress in Biophysics and Molecular Biology. 2005, JUN; 88(2): 209-231.
  1. 15.   In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6dimethylphenyl] amino]-2-pyrimidinyl]amino]-benzonitrile (R278474, rilpivirine)
  2. Janssen, P. A. J.; Lewi, P. J.; Arnold, E.; Daeyaert, F.; de Jonge, M.; Heeres, J.; Koymans, L.; Vinkers, M.; Guillemont, J.; Pasquier, E.; Kukla, M.; Ludovici, D.; Andries, K.; de Bethune, M. P.; Pauwels, R.; Das, K.; Clark, A. D.; Frenkel, Y. V.; Hughes, S. H.; Medaer, B.; De Knaep, F.; Bohets, H.; De Clerck, F.; Lampo, A.; Williams, P.; Stoffels, P.
  3. Journal of Medicinal Chemistry. 2005, MAR 24; 48(6): 1901-1909.
  1. 16.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 17.   Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
  2. Sarafianos, S. G.; Das, K.; Hughes, S. H.; Arnold, E.
  3. Current Opinion in Structural Biology. 2004, DEC; 14(6): 716-730.
  1. 18.   In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques
  2. Ambrose, Z.; Boltz, V.; Palmer, S.; Coffin, J. M.; Hughes, S. H.; KewalRamani, V. N.
  3. Journal of Virology. 2004, DEC; 78(24): 13553-13561.
  1. 19.   Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
  2. Das, K.; Clark, A. D.; Lewi, P. J.; Heeres, J.; de Jonge, M. R.; Koymans, L. M. H.; Vinkers, H. M.; Daeyaert, F.; Ludovici, D. W.; Kukla, M. J.; De Corte, B.; Kavash, R. W.; Ho, C. Y.; Ye, H.; Lichtenstein, M. A.; Andries, K.; Pauwels, R.; de Bethune, M. P.; Boyer, P. L.; Clark, P.; Hughes, S. H.; Janssen, P. A. J.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2004 47(10): 2550-2560.
  1. 20.   Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA
  2. Peletskaya, E. N.; Kogon, A. A.; Tuske, S.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004 78(7): 3387-3397.
  1. 21.   Low frequency non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant variants contribute to failure of efavirenz-containing regimens in NNRTI-experienced patients with negative standard genotypes for NNRTI mutations
  2. Mellors, J.; Palmer, S.; Nissley, D.; Kearney, M.; Halvas, E.; Bixby, C.; Demeter, L.; Eshleman, S.; Bennett, K.; Hart, S.; Vaida, F.; Wantman, M.; Coffin, J.; Hammer, S.
  3. Antiviral Therapy. 2003, JUN; 8(3): U129, Abstract 134-U130, Abstract 134.
  1. 22.   Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription
  2. Post, K.; Guo, J. H.; Howard, K. J.; Powell, M. D.; Miller, J. T.; Hizi, A.; Le Grice, S. F. J.; Levin, J. G.
  3. Journal of Virology. 2003 77(13): 7623-7634.
  1. 23.   Nontemplated nucleotide addition by HIV-1 reverse transcriptase
  2. Golinelli, M. P.; Hughes, S. H.
  3. Biochemistry. 2002 41(18): 5894-5906.
  1. 24.   The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
  2. Hsiou, Y.; Ding, J. P.; Das, K.; Clark, A. D.; Boyer, P. L.; Lewi, P.; Janssen, P. A. J.; Kleim, J. P.; Rosner, M.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 2001 309(2): 437-445.
  1. 25.   Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer
  2. Peletskaya, E. N.; Boyer, P. L.; Kogon, A. A.; Clark, P.; Kroth, H.; Sayer, J. M.; Jerina, D. M.; Hughes, S. H.
  3. Journal of Virology. 2001 75(19): 9435-9445.
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