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  1. 1.   alpha-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
  2. Ann, Jihyae; Czikora, Agnes; Saini, Amandeep S.; Zhou, Xiaoling; Mitchell, Gary A.; Lewin, Nancy E.; Peach, Megan; Blumberg, Peter M.; Lee, Jeewoo
  3. Journal of Medicinal Chemistry. 2018, Jul 26; 61(14): 6261-6276.
  1. 2.   Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor
  2. Newton, Alexandra C.; Brognard, John
  3. TRENDS IN PHARMACOLOGICAL SCIENCES. 2017, May; 38(5): 438-447.
  1. 3.   Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.
  2. Czikora, Agnes; Lundberg, Daniel J; Abramovitz, Adelle; Lewin, Nancy E; Kedei, Noemi; Peach, Megan L; Zhou, Xiaoling; Merritt, Raymond C; Craft, Elizabeth A; Braun, Derek C; Blumberg, Peter M
  3. The Journal of biological chemistry. 2016, May 20; 291(21): 11133-47.
  1. 4.   N-Methyl-Substituted Fluorescent DAG-Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity
  2. Gal, N.; Kolusheva, S.; Kedei, N.; Telek, A.; Naeem, T. A.; Lewin, N. E.; Lim, L.; Mannan, P.; Garfield, S. H.; El Kazzouli, S.; Sigano, D. M.; Marquez, V. E.; Blumberg, P. M.; Jelinek, R.
  3. Chembiochem. 2011, Oct; 12(15): 2331-2340.
  1. 5.   High Throughput Extraction of Plant, Marine and Fungal Specimens for Preservation of Biologically Active Molecules
  2. McCloud, T. G.
  3. Molecules. 2010, Jul; 15(7): 4526-4563.
  1. 6.   Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1
  2. Keck, G. E.; Poudel, Y. B.; Rudra, A.; Stephens, J. C.; Kedei, N.; Lewin, N. E.; Peach, M. L.; Blumberg, P. M.
  3. Angewandte Chemie-International Edition. 2010, Jun 21; 49(27): 4580-4584.
  1. 7.   Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
  2. Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; El Kazzouli, S.; Chung, J. U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5198-5220.
  1. 8.   Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins
  2. El Kazzouli, S.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5371-5386.
  1. 9.   Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta
  2. Choi, Y.; Pu, Y.; Peach, M. L.; Kang, J. H.; Lewin, N. E.; Sigano, D. M.; Garfield, S. H.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2007, Jul; 50(15): 3465-3481.
  1. 10.   Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups
  2. Malolanarasimhan, K.; Kedei, N.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Surawski, R. J.; Pavlyukovets, V. A.; Garfield, S. H.; Wincovitch, S.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2007, Mar; 50(5): 962-978.
  1. 11.   Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms
  2. Pu, Y. M.; Peach, M. L.; Garfield, S. H.; Wincovitch, S.; Marquez, V. E.; Blumberg, P. M.
  3. Journal of Biological Chemistry. 2006, Nov; 281(44): 33773-33788.
  1. 12.   Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions
  2. Kang, J. H.; Benzaria, S.; Sigano, D. M.; Lewin, N. E.; Pu, Y. M.; Peach, M. L.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2006, Jun; 49(11): 3185-3203.
  1. 13.   Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
  2. Liu, J.; Xie, Y. X.; Merrick, B. A.; Shen, J.; Ducharme, D. M. K.; Collins, J.; Diwan, B. A.; Logsdon, D.; Waalkes, M. P.
  3. Toxicology and Applied Pharmacology. 2006, Jun; 213(3): 216-223.
  1. 14.   p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
  2. Zhao, Y. F.; Chaiswing, L.; Velez, J. M.; Batinic-Haberle, I.; Colburn, N. H.; Oberley, T. D.; St Clair, D. K.
  3. Cancer Research. 2005, MAY 1; 65(9): 3745-3750.
  1. 15.   Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo
  2. Cataisson, C.; Pearson, A. J.; Torgerson, S.; Nedospasov, S. A.; Yuspa, S. H.
  3. Journal of Immunology. 2005, FEB 1; 174(3): 1686-1692.
  1. 16.   A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2
  2. Bream, J. H.; Hodge, D. L.; Gonsky, R.; Spolski, R.; Leonard, W. J.; Krebs, S.; Targan, S.; Morinobu, A.; O'Shea, J. J.; Young, H. A.
  3. Journal of Biological Chemistry. 2004, SEP 24; 279(39): 41249-41257.
  1. 17.   Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, SEP 23; 47(20): 4858-4864.
  1. 18.   Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands
  2. Lee, J.; Kim, S. Y.; Kang, J. H.; Acs, G.; Acs, P.; Blumberg, P. M.; Marquez, V. E.
  3. European Journal of Medicinal Chemistry. 2004 39(1): 69-77.
  1. 19.   Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms
  2. Hou, D. X.; Kai, K.; Li, J. J.; Lin, S. G.; Terahara, N.; Wakamatsu, M.; Fujii, M.; Young, M. R.; Colburn, N.
  3. Carcinogenesis. 2004 25(1): 29-36.
  1. 20.   Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers
  2. Waalkes, M. P.; Ward, J. M.; Diwan, B. A.
  3. Carcinogenesis. 2004 25(1): 133-141.
  1. 21.   Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(3): 644-655.
  1. 22.   Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis
  2. Kim, D. J.; Akiyama, T. E.; Harman, F. S.; Burns, A. M.; Shan, W. W.; Ward, J. M.; Kennett, M. J.; Gonzalez, F. J.; Peters, J. M.
  3. Journal of Biological Chemistry. 2004 279(22): 23719-23727.
  1. 23.   Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
  2. Waalkes, M. P.; Liu, J.; Ward, J. M.; Diwan, L. A.
  3. Toxicology. 2004 198(1-3): 31-38.
  1. 24.   Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation
  2. Dhar, A.; Hu, J.; Reeves, R.; Resar, L. M. S.; Colburn, N. H.
  3. Oncogene. 2004 23(25): 4466-4476.
  1. 25.   Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands
  2. Duan, D. H.; Lewin, N. E.; Sigano, D. M.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(12): 3248-3254.
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