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  1. 1.   Antiproliferative Cassaine Diterpenoid Amines from the Leaves and Twigs of the Traditional Thai Medicinal Plant Erythrophleum teysmannii (Kurz) Craib
  2. Orfanoudaki,Maria; Wang,Dongdong; Du,Lin; Ruchirawat, Somsak; Kittakoop, Prasat; Grkovic,Tanja; Mahidol, Chulabhorn; O'Keefe,Barry
  3. Journal of Ethnopharmacology. 2025, Jun 25; 352: 120167.
  1. 2.   Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization
  2. VanNatta, Jennifer M; Carlson, Graham J; Niu, Haichan; Bai, Ruoli; Wanniarachchi, Hashini I; Schuetze, Regan; Trawick, Mary Lynn; Hamel,Ernest; Mason, Ralph P; Pinney, Kevin G
  3. ACS Medicinal Chemistry Letters. 2025, Jun 12; 16(6): 1098-1107.
  1. 3.   Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma
  2. Nagarkar, Akanksha; Turbeville, Jackson; Hinshaw, Molly A; LeBoit, Philip E; Gagan, Jeffrey; Raffeld, Mark; Aldape, Kenneth; Shah, Niharika; Barr, Frederic G; Xi, Liqiang; Lee, Ina; Ferrone, Christina K; Pack, Svetlana D; Kaplan, Rosandra; Malone, Mary Frances Wedekind; Yohe,Marielle; Sargen, Michael R
  3. Journal of Cutaneous Pathology. 2025, Jun 03;
  1. 4.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 5.   Unusual Vilasinin-Class Limonoids from Trichilia rubescens
  2. Amuti, Saidanxia; Saito, Yohei; Fukuyoshi, Shuichi; Miyake, Katsunori; Newman,Dave; O'Keefe,Barry; Lee, Kuo-Hsiung; Nakagawa-Goto, Kyoko
  3. Molecules (Basel, Switzerland). 2024, Jan 30; 29(3):
  1. 6.   Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
  2. Ren, Wen; Deng, Yuling; Ward, Jacob D; Vairin, Rebecca; Bai,Ruoli; Wanniarachchi, Hashini I; Hamal, Khagendra B; Tankoano, Pouguiniseli E; Tamminga, Caleb S; Bueno, Lorena M A; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. European Journal of Medicinal Chemistry. 2023, Sep 06; 263: 115794.
  1. 7.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 8.   Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives
  2. Saito, Yohei; Taniguchi, Yukako; Hirazawa, Sachika; Miura, Yuta; Tsurimoto, Hiroyuki; Nakayoshi, Tomoki; Oda, Akifumi; Hamel,Ernest; Yamashita, Katsumi; Goto, Masuo; Nakagawa-Goto, Kyoko
  3. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021, OCT 15; 222
  1. 9.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 10.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 11.   Identification of proliferative diabetic retinopathy-associated genes on the protein-protein interaction network by using heat diffusion algorithm
  2. Zhang, Jian; Zhang, Meihua; Zhao,Huijie; Xu, Xun
  3. Biochimica et biophysica acta. Molecular basis of disease. 2020, OCT 1; 1866(10): 165794.
  1. 12.   New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action
  2. Daidone, Giuseppe; D'Anneo, Antonella; Raimondi, Maria Valeria; Raffa, Demetrio; Hamel,Ernest; Plescia, Fabiana; Lauricella, Marianna; Maggio, Benedetta
  3. Bioorganic chemistry. 2020, AUG; 101: pii: 103989.
  1. 13.   Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents
  2. Oliva, Paola; Onnis, Valentina; Balboni, Elisa; Hamel,Ernest; Estévez-Sarmiento, Francisco; Quintana, José; Estévez, Francisco; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Romagnoli, Romeo
  3. Molecules (Basel, Switzerland). 2020, May 06; 25(9):
  1. 14.   Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Cacciari, Barbara; Balzarini, Jan; Liekens, Sandra; Hamel,Ernest; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Zurlo, Matteo; Finotti, Alessia; Gambari, Roberto
  3. Molecules (Basel, Switzerland). 2020, Apr 07; 25(7): pii : molecules25071690.
  1. 15.   Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Kimatrai Salvador, Maria; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Viola, Giampietro; Bortolozzi, Roberta; Persoons, Leentje; Balzarini, Jan; Liekens, Sandra; Schols, Dominique
  3. Bioorganic chemistry. 2020, APR; 97: 103665.
  1. 16.   Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia
  2. Aimaiti, Simayijiang; Saito, Yohei; Fukuyoshi, Shuichi; Goto, Masuo; Miyake, Katsunori; Newman, David J; O'Keefe,Barry; Lee, Kuo-Hsiung; Nakagawa-Goto, Kyoko
  3. Molecules (Basel, Switzerland). 2019, Nov 05; 24(21): pii: E4005. .
  1. 17.   Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Camacho, Maria Encarnacion; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Grillo, Elisabetta; Bortolozzi, Roberta; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro
  3. European journal of medicinal chemistry. 2019, NOV 1; 181: 111577.
  1. 18.   Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy
  2. Peyser,Brian; Hermone,Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead,Melinda; McGrath,Connor; Gussio,Rick; Wipf, Peter
  3. Molecular cancer therapeutics. 2019, OCT; 18(10): 1765-1774.
  1. 19.   The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species
  2. He, Min; Grkovic,Tanja; Evans,Jason; Thornburg,Chris; Akee,Rhone; Thompson,Jerell; Whitt, James A; Harris,Matthew; Loyal,Jasmine; Britt,John; Jia, Libin; White, Jeffrey D; Newman, David J; O'Keefe,Barry
  3. Fitoterapia. 2019, SEP; 137(137):
  1. 20.   Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
  2. Zhang, Yu; Goto, Masuo; Oda, Akifumi; Hsu, Pei-Ling; Guo, Ling-Li; Fu, Yan-Hui; Morris-Natschke, Susan L.; Hamel,Ernest; Lee, Kuo-Hsiung; Hao, Xiao-Jiang
  3. Molecules (Basel, Switzerland). 2019, Mar 31; 24(7): pii: E1256.
  1. 21.   Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents
  2. Morigi, Rita; Locatelli, Alessandra; Leoni, Alberto; Rambaldi, Mirella; Bortolozzi, Roberta; Mattiuzzo, Elena; Ronca, Roberto; Maccarinelli, Federica; Hamel,Ernest; Bai,Ruoli; Brancale, Andrea; Viola, Giampietro
  3. European journal of medicinal chemistry. 2019, MAR 15; 166: 514-530.
  1. 22.   3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro
  3. Bioorganic chemistry. 2018, Oct; 80: 361-374.
  1. 23.   Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging
  2. Singh, Satyendra K; Singh, Shweta; Gadomski, Stephen; Sun, Lei; Pfannenstein, Alexander; Magidson, Valentin; Chen, Jack; Kozlov, Serguei; Tessarollo, Lino; Klarmann, Kimberly; Keller, Jonathan
  3. Cell Stem Cell. 2018, Aug 02; 23(2): 252-265.e8.
  1. 24.   2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
  2. Romagnoli, Romeo; Kimatrai Salvador, Maria; Schiaffino Ortega, Santiago; Baraldi, Pier Giovanni; Oliva, Paola; Baraldi, Stefania; Lopez-Cara, Luisa Carlota; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Mattiuzzo, Elena; Basso, Giuseppe; Viola, Giampietro
  3. European Journal of Medicinal Chemistry. 2018, Jan 1; 143: 683-698.
  1. 25.   The G-Protein-Coupled Chemoattractant Receptor Fpr2 Exacerbates High Glucose-Mediated Proinflammatory Responses of Müller Glial Cells
  2. Yu, Ying; Bao, Zhiyao; Wang, Xiaofei; Gong, Wang; Chen, Hui; Guan, Huaijin; Le, Yingying; Su, Shaobo; Chen, Keqiang; Wang, Jiming
  3. Frontiers in Immunology. 2017, Dec 19; 8: 1852.
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