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  1. 1.   Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Liu, H. P.; Zhang, M. C.; Worthy, K. M.; Bindu, L.; Yang, D. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005, JUL 1; 13(13): 4200-4208.
  1. 2.   Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform
  2. Kang, S. U.; Shi, Z. D.; Worthy, K. M.; Bindu, L. K.; Dharmawardana, P. G.; Choyke, S. J.; Bottaro, D. P.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2005, JUN 16; 48(12): 3945-3948.
  1. 3.   Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles
  2. Oishi, S.; Shi, Z. D.; Worthy, K. M.; Bindu, L. K.; Fisher, R. J.; Burke, T. R.
  3. Chembiochem. 2005, APR; 6(4): 668-674.
  1. 4.   Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic
  2. Shi, Z. D.; Karki, R. G.; Oishi, S.; Worthy, K. M.; Bindu, L. K.; Dharmawardana, P. G.; Nicklaus, M. C.; Bottaro, D. P.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry Letters. 2005, MAR 1; 15(5): 1385-1388.
  1. 5.   Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics
  2. Oishi, S.; Karki, R. G.; Kang, S. U.; Wang, X. Z.; Worthy, K. M.; Bindu, L. K.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2005, FEB 10; 48(3): 764-772.
  1. 6.   Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic
  2. Oishi, S.; Karki, R. G.; Shi, Z. D.; Worthy, K. M.; Bindu, L.; Chertov, O.; Esposito, D.; Frank, P.; Gillette, W. K.; Maderia, M.; Hartley, J.; Nicklaus, M. C.; Barchi, J. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005 13(7): 2431-2438.
  1. 7.   Utilization of a common pathway for the synthesis of high affinity macrocyclic Grh2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction
  2. Shi, Z. D.; Karki, R. G.; Worthy, K. M.; Bindu, L. K.; Nicklaus, M. C.; Fisher, R. J.; Burke, T. R.
  3. Chemistry & Biodiversity. 2005 2(4): 447-456.
  1. 8.   Design and synthesis biotinylated ligands exhibiting high GRB2 SH2 domain-binding affinity
  2. Shi, Z. D.; Liu, H. P.; Zhang, M.; Roberts, L. R.; Fisher, R. J.; Yang, D. J.; Bottaro, D.; Linehan, M.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 242-MEDI, Abstract U951-242-MEDI, Abstract U951.
  1. 9.   Examination of the role of phosphoryl-mimicking functionality in the binding of picomolar-affinity Grb2 SH2 domain-binding macrocycles
  2. Kang, S.; Shi, Z. D.; Lee, K.; Worthy, K. M.; Fisher, R. J.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(041-MEDI, Part 2): U12-U12.
  1. 10.   Design, synthesis and utilization of biotinylated macrocyclic Grb2 SH2 domain-binding ligands
  2. Shi, Z. D.; Lee, K.; Liu, H. P.; Zhang, M. C.; Roberts, L. R.; Fisher, R. J.; Yang, D. J.; Bottaro, D.; Linehan, M.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(040-MEDI, Part 2): U12-U12.
  1. 11.   Synthesis of alpha,alpha-disubstituted 4-phosphonophenylalanine analogues as conformationally-constrained phosphotyrosyl mimetics
  2. Oishi, S.; Kang, S. U.; Liu, H. P.; Zhang, M. C.; Yang, D. J.; Deschamps, J. R.; Burke, T. R.
  3. Tetrahedron. 2004 60(13): 2971-2977.
  1. 12.   Ectopic EphA4 receptor induces posterior protrusions via FGF signaling in Xenopus embryos
  2. Park, E. K.; Warner, N.; Bong, Y. S.; Stapleton, D.; Maeda, R.; Pawson, T.; Daar, I. O.
  3. Molecular Biology of the Cell. 2004 15(4): 1647-1655.
  1. 13.   Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Lee, K.; Wei, C. Q.; Roberts, L. R.; Worthy, K. M.; Fisher, R. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2004 47(4): 788-791.
  1. 14.   Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands
  2. Shi, Z. D.; Wei, C. Q.; Lee, K. O.; Liu, H. P.; Zhang, M. C.; Araki, T.; Roberts, L. R.; Worthy, K. M.; Fisher, R. J.; Neel, B. G.; Kelley, J. A.; Yang, D. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2004 47(8): 2166-2169.
  1. 15.   Macrocyclization in the design of non phosphorus-containing GRB2 SH2 domain-binding ligands that exhibit high affinity in cell-based assays
  2. Shi, Z. D.; Wei, C. Q.; Gao, Y.; Lee, K.; Vasselli, J.; Zhang, M. C.; Liu, H. P.; Yang, D. J.; Linehan, M.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2003 225(Part 2): U174-U174.
  1. 16.   Design and synthesis of a novel macrocycle that exhibits high Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Wei, C. Q.; Gao, Y.; Lee, K.; Vasselli, J.; Zhang, M. C.; Liu, H. P.; Yang, D. J.; Linehan, M.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2003 225(Part 2): U191-U192.
  1. 17.   Synthesis of N-Fmoc 3-(4-(di-(tert- butyl)phosphonomethyl)phenyl)pipecolic acid as a conformationally constrained phosphotyrosyl mimetic suitably protected for peptide synthesis
  2. Liu, D. G.; Wang, X. Z.; Gao, Y.; Li, B. H.; Yang, D.; Burke, T. R.
  3. Tetrahedron. 2002 58(52): 10423-10428.
  1. 18.   Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors
  2. Burke, T. R.; Yao, Z. J.; Liu, D. G.; Voigt, J.; Gao, Y.
  3. Biopolymers. 2001 60(1): 32-44.
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