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  1. 1.   Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities
  2. Desai, Parth; Takahashi, Nobuyuki; Kumar, Rajesh; Nichols, Samantha; Malin, Justin; Hunt, Allison; Schultz, Christopher; Cao, Yingying; Tillo, Desiree; Nousome, Darryl; Chauhan, Lakshya; Sciuto, Linda; Jordan, Kimberly; Rajapakse, Vinodh; Tandon, Mayank; Lissa, Delphine; Zhang, Yang; Kumar, Suresh; Pongor, Lorinc; Singh, Abhay; Schroder, Brett; Sharma, Ajit Kumar; Chang, Tiangen; Vilimas, Rasa; Pinkiert, Danielle; Graham, Chante; Butcher,Donna; Warner,Andrew; Sebastian, Robin; Mahon, Mimi; Baker, Karen; Cheng, Jennifer; Berger, Ann; Lake, Ross; Abel, Melissa; Krishnamurthy, Manan; Chrisafis, George; Fitzgerald, Peter; Nirula, Micheal; Goyal, Shubhank; Atkinson, Devon; Bateman, Nicholas W; Abulez, Tamara; Nair, Govind; Apolo, Andrea; Guha, Udayan; Karim,Baktiar; El Meskini,Rajaa; Ohler,Zoe; Jolly, Mohit Kumar; Schaffer, Alejandro; Ruppin, Eytan; Kleiner, David; Miettinen, Markku; Brown, G Tom; Hewitt, Stephen; Conrads, Thomas; Thomas, Anish
  3. Cell Reports. Medicine. 2024, Jun 18; 5(6): 101610.
  1. 2.   Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design
  2. Shaw,Gary; Fan,Lixin; Cherry,Scott; Shi,Genbin; Tropea, Joseph E; Ji,Xinhua
  3. Current Research in Structural Biology. 2023, Jan 30; 5: 100095.
  1. 3.   Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach
  2. Smith, Kyle P; Lee, Woonghee; Tonelli, Marco; Lee, Yeongjoon; Light, Samuel H; Cornilescu,Gabriel; Chakravarthy, Srinivas
  3. Protein Science : a Publication of the Protein Society. 2022, Feb 08; 31(5):
  1. 4.   Arrow pushing in RNA modification sequencing
  2. Bartee,David; Thalalla Gamage,Supuni; Link,Courtney; Meier,Jordan
  3. Chemical Society reviews. 2021, Jul 14;
  1. 5.   Structural mimicry drives HIV-1 Rev-mediated HERV-K expression
  2. O'Carroll, Ina P; Fan,Lixin; Kroupa,Tomas; McShane, Erin K; Theodore, Christophe; Yates, Elizabeth A; Kondrup, Benjamin; Ding,Jienyu; Martin, Tyler S; Rein,Alan; Wang,Yun-Xing
  3. Journal of molecular biology. 2020, Dec 4; 432(24): pii: S0022-2836(20)30630-6.
  1. 6.   SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations
  2. Liao, Tsung-Jen; Jang,Hyunbum; Fushman, David; Nussinov,Ruth
  3. The Journal of chemical physics. 2020, Jul 28; 153(4): 045106.
  1. 7.   Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival
  2. Higuchi, Takashi; Sugisawa, Norihiko; Park, Jun Ho; Sun, Yu; Zhu, Guangwei; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Translational oncology. 2020, Jul 10; 13(10): 100826.
  1. 8.   Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems
  2. Boer, Robert E.; Torrey, Zachary R.; Schneekloth,Jay
  3. ACS CHEMICAL BIOLOGY. 2020, Apr 17; 15(4): 808-818.
  1. 9.   High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1
  2. Liao,Tsung-Jen; Jang,Hyunbum; Nussinov,Ruth; Fushman, David
  3. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2020, Feb 19; 142: 3401-3411.
  1. 10.   Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy
  2. Peyser,Brian; Hermone,Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead,Melinda; McGrath,Connor; Gussio,Rick; Wipf, Peter
  3. Molecular cancer therapeutics. 2019, OCT; 18(10): 1765-1774.
  1. 11.   Design and characterization of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems
  2. Harding, Rachel J; Loppnau, Peter; Ackloo, Suzanne; Lemak, Alexander; Hutchinson, Ashley; Hunt, Brittany; Holehouse, Alex S; Ho, Jolene C; Fan, Lixin; Toledo-Sherman, Leticia; Seitova, Alma; Arrowsmith, Cheryl H
  3. The Journal of biological chemistry. 2019, APR 26; 294(17): 6986-7001.
  1. 12.   New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model
  2. Konstantinovic, Jelena; Kiris, Erkan; Kota, Krishna P.; Kugelman-Tonos, Johanny; Videnovic, Milica; Cazares, Lisa H.; Jovanovic, Natasa Terzic; Verbic, Tatjana Z.; Andjelkoyic, Boban; Duplantier, Allen J.; Bavari, Sina; Solaja, Bogdan A.
  3. Journal of Medicinal Chemistry. 2018, Feb 22; 61(4): 1595-1608.
  1. 13.   Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution
  2. Sathiyamoorthy, Karthik; Vijayalakshmi, J; Tirupati, Bhramara; Fan, Lixin; Saper, Mark A
  3. The Journal of Biological Chemistry. 2017, Oct 27; 292(43): 17626-17642.
  1. 14.   Three-dimensional structure of the 3 ' X-tail of hepatitis C virus RNA in monomeric and dimeric states
  2. Cantero-Camacho, Angel; Fan, Lixin; Wang, Yun-Xing; Gallego, José
  3. RNA (New York, N.Y.). 2017, Sep 01; 23(9): 1465-1476.
  1. 15.   A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways
  2. Zlotkowski, Katherine; Hewitt, Will; Sinniah, Ranu S; Tropea, Joseph; Needle, Danielle; Lountos, George; Barchi, Joe; Waugh, David; Schneekloth, Jay
  3. SLAS Discovery. 2017, Jul; 22(6): 760-766.
  1. 16.   The Functional Cycle of Rnt1p: Five Consecutive Steps of Double-Stranded RNA Processing by a Eukaryotic RNase III
  2. Song, He; Fang, Xianyang; Jin, Lan; Shaw, Gary; Wang, Yun-Xing; Ji, Xinhua
  3. STRUCTURE. 2017, Feb 7; 25(2): 353-363.
  1. 17.   High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics
  2. Day, C. R.; Chen, H.; Coulon, A.; Meier, J. L.; Larson, D. R.
  3. Methods (San Diego, Calif.). 2016, 1-Mar; 96: 59-68.
  1. 18.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 19.   Two ZnF-UBP Domains in Isopeptidase T (USP5)
  2. Avvakumov, G. V.; Walker, J. R.; Xue, S.; Allali-Hassani, A.; Asinas, A.; Nair, U. B.; Fang, X. Y.; Zuo, X. B.; Wane, Y. X.; Wilkinson, K. D.; Dhe-Paganon, S.
  3. Biochemistry. 2012, Feb; 51(6): 1188-1198.
  1. 20.   Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition
  2. Guo, W.; Wu, S. H.; Wang, L.; Wei, X. L.; Liu, X. Y.; Wang, J.; Lu, Z. M.; Hollingshead, M.; Fang, B. L.
  3. Plos One. 2011, Dec; 6(12):
  1. 22.   RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
  2. Lipkowitz, S.; Weissman, A. M.
  3. Nature Reviews Cancer. 2011, Sep; 11(9): 629-643.
  1. 23.   Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel
  2. Liu, F.; Park, J. E.; Qian, W. J.; Lim, D.; Graber, M.; Berg, T.; Yaffe, M. B.; Lee, K. S.; Burke, T. R.
  3. Nature Chemical Biology. 2011, Sep; 7(9): 595-601.
  1. 24.   A Dual-Readout F(2) Assay That Combines Fluorescence Resonance Energy Transfer and Fluorescence Polarization for Monitoring Bimolecular Interactions
  2. Du, Y. H.; Nikolovska-Coleska, Z.; Qui, M.; Li, L.; Lewis, I.; Dingledine, R.; Stuckey, J. A.; Krajewski, K.; Roller, P. P.; Wang, S. M.; Fu, H. A.
  3. Assay and Drug Development Technologies. 2011, Aug; 9(4): 382-393.
  1. 25.   Synthesis, Activity, and Structural Analysis of Novel alpha-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H
  2. Chung, S. M.; Himmel, D. M.; Jiang, J. K.; Wojtak, K.; Bauman, J. D.; Rausch, J. W.; Wilson, J. A.; Beutler, J. A.; Thomas, C. J.; Arnold, E.; Le Grice, S. F. J.
  3. Journal of Medicinal Chemistry. 2011, Jul; 54(13): 4462-4473.
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