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Selected human leukocyte antigen class II polymorphisms and risk of adult glioma

  1. Author:
    Bassig, B. A.
    Inskip, P. D.
    Burdette, L.
    Shapiro, W. R.
    Selker, R. G.
    Fine, H. A.
    Loeffler, J. S.
    Black, P. M.
    Dubrow, R.
    Brenner, A. V.

  2. Author Address

    [Inskip, PD; Brenner, AV] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA [Bassig, BA; Dubrow, R] Yale Univ, Sch Med, Yale Sch Publ Hlth, New Haven, CT 06510 USA [Burdette, L] NCI Frederick, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Ft Detrick, MD 21702 USA [Shapiro, WR] St Josephs Hosp, Barrow Neurol Inst, Phoenix, AZ 85013 USA [Selker, RG] Western Penn Hosp, Div Neurosurg, Pittsburgh, PA 15224 USA [Fine, HA] NCI, Neurooncol Branch, Bethesda, MD 20892 USA [Loeffler, JS] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA [Black, PM] Brigham & Womens Hosp, Boston, MA 02115 USA;Brenner, AV (reprint author), NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,MSC 7362, Bethesda, MD 20892 USA;brennera@mail.nih.gov
    1. Year: 2011
    2. Date: Apr
  2. Journal: Journal of Neuroimmunology
    1. 233
    2. 1-2
    3. Pages: 185-191
  4. Type of Article: Article
  5. ISSN: 0165-5728
  1. Abstract:

    Few studies have examined the relationship between human leukocyte antigen (HLA) polymorphisms and adult glioma, particularly at class II loci. We evaluated the association between selected HLA class II polymorphisms and adult glioma in a large, hospital-based case-control study, using unconditional logistic regression. DQB1*06 (OR=1.67, 95% CI=1.17-2.39) and DRB1*13 (OR=1.69, 95% CI=1.08-2.64) alleles were associated with an increased risk of glioma, while the DQB1*05 allele showed an inverse association (OR=0.63, 95% CI=0.43-0.93). These results, which were of borderline significance once controlled for the false discovery rate, suggest a potential role for the DQB1*06, DQB1*05, and DRB1*13 alleles in glioma susceptibility. (C) 2010 Published by Elsevier B.V.

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External Sources

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  2. DOI: 10.1016/j.jneuroim.2010.11.005
  3. View record in Web of Science®
  4. WOS: 000290070000024

Library Notes

  1. Fiscal Year: FY2010-2011
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