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Poly(diol-co-citrate)s as Novel Elastomeric Perivascular Wraps for the Reduction of Neointimal Hyperplasia

  1. Author:
    Serrano, M. C.
    Vavra, A. K.
    Jen, M.
    Hogg, M. E.
    Murar, J.
    Martinez, J.
    Keefer, L. K.
    Ameer, G. A.
    Kibbe, M. R.

  2. Author Address

    [Serrano, MC; Jen, M; Ameer, GA] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA [Vavra, AK; Hogg, ME; Murar, J; Martinez, J; Ameer, GA; Kibbe, MR] Northwestern Univ, Inst BioNanotechnol Med, Div Vasc Surg, Feinberg Sch Med, Chicago, IL 60611 USA [Keefer, LK] NCI, Comparat Carcinogenesis Lab, Ctr Canc Res, Frederick, MD 21702 USA;Ameer, GA (reprint author), Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA;g-ameer@northwestern.edu mkibbe@nmh.org
    1. Year: 2011
    2. Date: May
  2. Journal: Macromolecular Bioscience
    1. 11
    2. 5
    3. Pages: 700-709
  4. Type of Article: Article
  5. ISSN: 1616-5187
  1. Abstract:

    The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.

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External Sources

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  2. DOI: 10.1002/mabi.201000509
  3. View record in Web of Science®
  4. WOS: 000290443200014

Library Notes

  1. Fiscal Year: FY2010-2011
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