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Homozygous Deletions At 3p12 in Breast and Lung Cancer

  1. Author:
    Sundaresan, V.
    Chung, G.
    Heppellparton, A.
    Xiong, J.
    Grundy, C.
    Roberts, I.
    James, L.
    Cahn, A.
    Bench, A.
    Douglas, J.
    Minna, J.
    Sekido, Y.
    Lerman, M.
    Latif, F.
    Bergh, J.
    Li, H.
    Lowe, N.
    Ogilvie, D.
    Rabbitts, P.

  2. Author Address

    Rabbitts P MRC CTR ALDERLEY PK MACCLESFIELD SK10 4TG CHESHIRE ENGLAND MRC CTR MACCLESFIELD SK10 4TG CHESHIRE ENGLAND ZENECA PHARMACEUT MACCLESFIELD SK10 4TG CHESHIRE ENGLAND UNIV TEXAS SW MED CTR HAMON CTR THERAPEUT ONCOL RES DALLAS, TX 75235 USA NCI FREDERICK CANC RES FACIL IMMUNOBIOL LAB FREDERICK, MD 21701 USA UNIV UPPSALA AKAD SJUKHUSET DEPT ONCOL S-75185 UPPSALA SWEDEN
    1. Year: 1998
  2. Journal: Oncogene
    1. 17
    2. 13
    3. Pages: 1723-1729
  4. Type of Article: Article
  1. Abstract:

    We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family. [References: 31]

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