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Genomewide Linkage Scan for Diabetic Renal Failure and Albuminuria: The FIND Study

  1. Author:
    Igo, R. P.
    Iyengar, S. K.
    Nicholas, S. B.
    Goddard, K. A. B.
    Langefeld, C. D.
    Hanson, R. L.
    Duggirala, R.
    Divers, J.
    Abboud, H.
    Adler, S. G.
    Arar, N. H.
    Horvath, A.
    Elston, R. C.
    Bowden, D. W.
    Guo, X. Q.
    Ipp, E.
    Kao, W. H. L.
    Kimmel, P. L.
    Knowler, W. C.
    Meoni, L. A.
    Molineros, J.
    Nelson, R. G.
    Pahl, M. V.
    Parekh, R. S.
    Rasooly, R. S.
    Schelling, J. R.
    Shah, V. O.
    Smith, M. W.
    Winkler, C. A.
    Zager, P. G.
    Sedor, J. R.
    Freedman, B. I.
    Family Invest Nephropathy, D.

  2. Author Address

    [Iyengar, SK] Case Western Reserve Univ, Dept Epidemiol & Biostat, Genet Anal & Data Coordinating Ctr, Cleveland, OH 44106 USA [Nicholas, SB] Univ Calif Los Angeles, Los Angeles, CA USA [Goddard, KAB] Kaiser Permanente NW, Ctr Hlth Res, Portland, OR USA [Langefeld, CD; Divers, J; Bowden, DW; Freedman, BI] Wake Forest Sch Med, Winston Salem, NC USA [Hanson, RL; Knowler, WC; Nelson, RG] NIDDKD, Phoenix, AZ USA [Duggirala, R] Texas Biomed Res Inst, San Antonio, TX USA [Abboud, H; Arar, NH] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA [Adler, SG; Ipp, E] Harbor UCLA Med Ctr, Torrance, CA 90509 USA [Guo, XQ] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA [Kao, WHL; Meoni, LA; Parekh, RS] Johns Hopkins Univ, Baltimore, MD USA [Kimmel, PL; Rasooly, RS] NIDDK, NIH, Bethesda, MD USA [Molineros, J] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA [Pahl, MV] Univ Calif Irvine, Irvine, CA USA [Shah, VO; Zager, PG] Univ New Mexico, Albuquerque, NM 87131 USA [Winkler, CA] NCI, Basic Res Lab, Ctr Canc Res, SAIC Frederick, Frederick, MD 21701 USA [Smith, MW] NCI, Genet & Genom Grp, Adv Technol Program, SAIC Frederick, Frederick, MD 21701 USA;Iyengar, SK (reprint author), Case Western Reserve Univ, Dept Epidemiol & Biostat, Genet Anal & Data Coordinating Ctr, Wolstein Res Bldg,Rm 1300,10900 Euclid Ave, Cleveland, OH 44106 USA;ski@case.edu
    1. Year: 2011
    2. Date: May
  2. Journal: American Journal of Nephrology
    1. 33
    2. 5
    3. Pages: 381-389
  4. Type of Article: Article
  5. ISSN: 0250-8095
  1. Abstract:

    Background: Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with type 1 and type 2 diabetes. The multicenter FIND consortium aims to identify genes for DN and its associated quantitative traits, e.g. the urine albumin:creatinine ratio (ACR). Herein, the results of whole-genome linkage analysis and a sparse association scan for ACR and a dichotomous DN phenotype are reported in diabetic individuals. Methods: A genomewide scan comprising more than 5,500 autosomal single nucleotide polymorphism markers (average spacing of 0.6 cM) was performed on 1,235 nuclear and extended pedigrees (3,972 diabetic participants) ascertained for DN from African-American (AA), American-Indian (AI), European-American (EA) and Mexican-American (MA) populations. Results: Strong evidence for linkage to DN was detected on chromosome 6p (p = 8.0 x 10(-5) LOD = 3.09) in EA families as well as suggestive evidence for linkage to chromosome 7p in Al families. Regions on chromosomes 3p in AA, 7q in EA, 16q in AA and 22q in MA displayed suggestive evidence of linkage for urine ACR. The linkage peak on chromosome 22q overlaps the MYH9/APOL1 gene region, previously implicated in AA diabetic and nondiabetic nephropathies. Conclusion:These results strengthen the evidence for previously identified genomic regions and implicate several novel loci potentially involved in the pathogenesis of DN. Copyright (C) 2011 S. Karger AG, Basel

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External Sources

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  2. DOI: 10.1159/000326763
  3. View record in Web of Science®
  4. WOS: 000290841100001

Library Notes

  1. Fiscal Year: FY2010-2011
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