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Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii

  1. Author:
    Diyabalanage, T.
    Ratnayake, R.
    Wilson, J. A.
    Henrich, C. J.
    Beutler, J. A.
    Colburn, N. H.
    McMahon, J. B.
    Gustafson, K. R.

  2. Author Address

    [Diyabalanage, T; Ratnayake, R; Wilson, JA; Henrich, CJ; Beutler, JA; McMahon, JB; Gustafson, KR] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA [Henrich, CJ] NCI, SAIC Frederick, Frederick, MD 21702 USA [Colburn, NH] NCI, Lab Canc Prevent, Ctr Canc Res, Frederick, MD 21702 USA;Gustafson, KR (reprint author), NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA;gustafki@mail.nih.gov
    1. Year: 2011
    2. Date: Aug
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 21
    2. 15
    3. Pages: 4397-4399
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    A high throughput screen for inhibitors of the oncogenic transcription factor activator protein-1 (AP-1) was applied to the NCI repository of natural product extracts. The liphophilic extract of the plant Nothospondias staudtii (Simaroubaceae) displayed significant AP-1 inhibition. Bioassay-guided fractionation of the extract lead to a new quassinoid named nothospondin (1), and the known compound glaucarubinone (2). The structure of 1 was elucidated by spectroscopic methods. Compounds 1 and 2 showed potent, dose-dependent AP-1 inhibition at noncytotoxic concentrations. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.bmcl.2011.06.044
  3. View record in Web of Science®
  4. WOS: 000292729900004

Library Notes

  1. Fiscal Year: FY2010-2011
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