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Induced Production of N-Formyl Alkaloids from Aspergillus fumigatus by Co-culture with Streptomyces peucetius

  1. Author:
    Zuck, K. M.
    Shipley, S.
    Newman, D. J.

  2. Author Address

    [Zuck, KM; Shipley, S] SAIC Frederick Inc, Frederick, MD 21702 USA [Newman, DJ] NCI, Nat Prod Branch, Frederick, MD 21702 USA;Zuck, KM (reprint author), SAIC Frederick Inc, POB B, Frederick, MD 21702 USA;zuckk@mail.nih.gov
    1. Year: 2011
    2. Date: Jul
  2. Journal: Journal of Natural Products
    1. 74
    2. 7
    3. Pages: 1653-1657
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    Co-culture of the fungus Aspergillus fumigatus with the bacteria Streptomyces peucetius led to the induction of production of formyl xanthocillin analogues. This mixed fermentation yielded two new metabolites, fumiformamide (1) and N,N'-((1Z,3Z)-1,4-bis(4-methoxyphenyl)buta-1,3-diene-2,3-diyl)diformamid e (2), together with two known N-formyl derivatives and the xanthocillin analogue BU-4704. The structures were determined by spectroscopic methods and by comparison with literature. Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity.

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External Sources

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  2. DOI: 10.1021/np200255f
  3. View record in Web of Science®
  4. WOS: 000293036100016

Library Notes

  1. Fiscal Year: FY2010-2011
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