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Prevalence of Etravirine-Associated Mutations in Clinical Samples With Genotypic Resistance to Nevirapine and Efavirenz in Brazilian Clinics

  1. Author:
    Martins, A. N.
    Arruda, M. B.
    Aleixo, A. W.
    Pires, A. F.
    Greco, D. B.
    Brindeiro, R. D.
    Tanuri, A.

  2. Author Address

    [Martins, AN; Arruda, MB; Pires, AF; Brindeiro, RD; Tanuri, A] Univ Fed Rio de Janeiro, Dept Genet, Lab Virol Mol, Rio De Janeiro, Brazil [Martins, AN] NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21701 USA [Arruda, MB; Pires, AF] Univ Fed Rio de Janeiro, Dept Biochem, Inst Chem, Rio De Janeiro, Brazil [Aleixo, AW; Greco, DB] Univ Fed Minas Gerais, Lab Imunol & Biol Mol, Infect Dis Serv, Belo Horizonte, MG, Brazil [Aleixo, AW; Greco, DB] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil;Tanuri, A (reprint author), Univ Fed Rio de Janeiro, Dept Genet, Lab Virol Mol, Rio De Janeiro, Brazil;atanuri@biologia.ufrj.br
    1. Year: 2011
    2. Date: Aug
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 57
    2. Pages: S193-S196
  4. Type of Article: Article
  5. ISSN: 1525-4135
  1. Abstract:

    Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.

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External Sources

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  2. DOI: 10.1097/QAI.0b013e31821e9cf6
  3. View record in Web of Science®
  4. WOS: 000293235900011

Library Notes

  1. Fiscal Year: FY2010-2011
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