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The landscape of recombination in African Americans

  1. Author:
    Hinch, A. G.
    Tandon, A.
    Patterson, N.
    Song, Y. L.
    Rohland, N.
    Palmer, C. D.
    Chen, G. K.
    Wang, K.
    Buxbaum, S. G.
    Akylbekova, E. L.
    Aldrich, M. C.
    Ambrosone, C. B.
    Amos, C.
    Bandera, E. V.
    Berndt, S. I.
    Bernstein, L.
    Blot, W. J.
    Bock, C. H.
    Boerwinkle, E.
    Cai, Q. Y.
    Caporaso, N.
    Casey, G.
    Cupples, L. A.
    Deming, S. L.
    Diver, W. R.
    Divers, J.
    Fornage, M.
    Gillanders, E. M.
    Glessner, J.
    Harris, C. C.
    Hu, J. J.
    Ingles, S. A.
    Isaacs, W.
    John, E. M.
    Kao, W. H. L.
    Keating, B.
    Kittles, R. A.
    Kolonel, L. N.
    Larkin, E.
    Le Marchand, L.
    McNeill, L. H.
    Millikan, R. C.
    Murphy, A.
    Musani, S.
    Neslund-Dudas, C.
    Nyante, S.
    Papanicolaou, G. J.
    Press, M. F.
    Psaty, B. M.
    Reiner, A. P.
    Rich, S. S.
    Rodriguez-Gil, J. L.
    Rotter, J. I.
    Rybicki, B. A.
    Schwartz, A. G.
    Signorello, L. B.
    Spitz, M.
    Strom, S. S.
    Thun, M. J.
    Tucker, M. A.
    Wang, Z. M.
    Wiencke, J. K.
    Witte, J. S.
    Wrensch, M.
    Wu, X. F.
    Yamamura, Y.
    Zanetti, K. A.
    Zheng, W.
    Ziegler, R. G.
    Zhu, X. F.
    Redline, S.
    Hirschhorn, J. N.
    Henderson, B. E.
    Taylor, H. A.
    Price, A. L.
    Hakonarson, H.
    Chanock, S. J.
    Haiman, C. A.
    Wilson, J. G.
    Reich, D.
    Myers, S. R.

  2. Author Address

    [Tandon, Arti; Patterson, Nick; Rohland, Nadin; Reich, David] Broad Inst MIT & Harvard, Cambridge Ctr 7, Cambridge, MA 02142 USA. [Hinch, Anjali G.; Myers, Simon R.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England. [Tandon, Arti; Rohland, Nadin; Reich, David] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Song, Yunli; Myers, Simon R.] Univ Oxford, Dept Stat, Oxford OX1 3TG, England. [Palmer, Cameron D.; Hirschhorn, Joel N.] Broad Inst, Program Med & Populat Genet, Cambridge Ctr 7, Cambridge, MA 02142 USA. [Palmer, Cameron D.; Hirschhorn, Joel N.] Childrens Hosp Boston, Div Endocrinol, Boston, MA 02115 USA. [Palmer, Cameron D.; Hirschhorn, Joel N.] Childrens Hosp Boston, Div Genet, Boston, MA 02115 USA. [Palmer, Cameron D.; Hirschhorn, Joel N.] Childrens Hosp Boston, Program Genom, Boston, MA 02115 USA. [Chen, Gary K.; Casey, Graham; Ingles, Sue A.; Press, Michael F.; Henderson, Brian E.; Haiman, Christopher A.] Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA. [Chen, Gary K.; Casey, Graham; Ingles, Sue A.; Press, Michael F.; Henderson, Brian E.; Haiman, Christopher A.] Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Pathol, Los Angeles, CA 90033 USA. [Wang, Kai] Univ So Calif, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA. [Wang, Kai; Glessner, Joseph; Keating, Brendan; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA. [Buxbaum, Sarah G.; Akylbekova, Ermeg L.] Jackson State Univ, Jackson Heart Study Coordinating Ctr, Jackson, MS 39213 USA. [Akylbekova, Ermeg L.; Musani, Solomon; Taylor, Herman A., Jr.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA. [Aldrich, Melinda C.] Vanderbilt Univ, Sch Med, Dept Thorac Surg, Nashville, TN 37203 USA. [Aldrich, Melinda C.; Blot, William J.; Cai, Qiuyin; Deming, Sandra L.; Signorello, Lisa B.; Zheng, Wei] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol,Dept Med, Nashville, TN 37203 USA. [Aldrich, Melinda C.; Blot, William J.; Cai, Qiuyin; Deming, Sandra L.; Signorello, Lisa B.; Zheng, Wei] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37203 USA. [Ambrosone, Christine B.] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA. [Amos, Christopher; Spitz, Margaret; Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA. [Bandera, Elisa V.] Canc Inst New Jersey, New Brunswick, NJ 08903 USA. [Berndt, Sonja I.; Caporaso, Neil; Tucker, Margaret A.; Ziegler, Regina G.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Bernstein, Leslie] City Hope Natl Med Ctr, Div Canc Etiol, Dept Populat Sci, Beckman Res Inst, Duarte, CA 91010 USA. [Blot, William J.; Signorello, Lisa B.] Int Epidemiol Inst, Rockville, MD 20850 USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ Med, Karmanos Canc Inst, Detroit, MI 48201 USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ Med, Dept Oncol, Detroit, MI 48201 USA. [Boerwinkle, Eric] Univ Texas Houston, Ctr Human Genet, Houston, TX 77030 USA. [Boerwinkle, Eric] Univ Texas Houston, Div Epidemiol, Houston, TX 77030 USA. [Cupples, L. Adrienne] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Cupples, L. Adrienne] Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA. [Diver, W. Ryan; Thun, Michael J.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA. [Divers, Jasmin] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA. [Fornage, Myriam; Gillanders, Elizabeth M.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Inst Mol Med, Houston, TX 77030 USA. [Fornage, Myriam; Gillanders, Elizabeth M.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol, Houston, TX 77030 USA. [Zanetti, Krista A.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Harris, Curtis C.; Zanetti, Krista A.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA. [Hu, Jennifer J.; Rodriguez-Gil, Jorge L.] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA. [Hu, Jennifer J.; Rodriguez-Gil, Jorge L.] Univ Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA. [Isaacs, William] Johns Hopkins Hosp & Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA. [John, Esther M.] Canc Prevent Inst Calif, Fremont, CA 94538 USA. [John, Esther M.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [John, Esther M.] Stanford Canc Ctr, Stanford, CA 94305 USA. [Kao, W. H. Linda] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Kittles, Rick A.] Univ Illinois, Dept Med, Chicago, IL 60607 USA. [Kolonel, Laurence N.; Le Marchand, Loic] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96813 USA. [Larkin, Emma] Vanderbilt Univ, Med Ctr, Div Allergy Pulm & Crit Care, Dept Med,Med Ctr E, Nashville, TN 37232 USA. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Div OVP Canc Prevent & Populat Sci, Houston, TX 77030 USA. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Ctr Community Implementat & Disseminat Res, Duncan Family Inst, Houston, TX 77030 USA. [Millikan, Robert C.; Nyante, Sarah] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Millikan, Robert C.; Nyante, Sarah] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Murphy, Adam] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA. [Neslund-Dudas, Christine; Rybicki, Benjamin A.] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA. [Papanicolaou, George J.] NHLBI, Div Cardiovasc Sci, Bethesda, MD 20892 USA. [Psaty, Bruce M.] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA. [Psaty, Bruce M.] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA. [Psaty, Bruce M.] Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA. [Psaty, Bruce M.] Grp Hlth Res Inst, Seattle, WA 98101 USA. [Psaty, Bruce M.] Grp Hlth Cooperat Puget Sound, Seattle, WA 98101 USA. [Reiner, Alex P.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Rich, Stephen S.] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA. [Rotter, Jerome I.] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA. [Wang, Zhaoming] Natl Canc Inst Frederick, Core Genotype Facil, SAIC Frederick Inc, Frederick, MD 20877 USA. [Witte, John S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Human Genet, San Francisco, CA 94158 USA. [Witte, John S.] Univ Calif San Francisco, Dept Urol, Inst Human Genet, San Francisco, CA 94158 USA. [Zhu, Xiaofeng] Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA. [Redline, Susan] Brigham & Womens Hosp, Dept Med, Div Sleep Med, Boston, MA 02115 USA. [Hirschhorn, Joel N.] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Taylor, Herman A., Jr.] Jackson State Univ, Jackson, MS 39217 USA. [Taylor, Herman A., Jr.] Tougaloo Coll, Tougaloo, MS 39174 USA. [Price, Alkes L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Price, Alkes L.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Hakonarson, Hakon] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA. [Wilson, James G.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.;Reich, D (reprint author), Broad Inst MIT & Harvard, Cambridge Ctr 7, Cambridge, MA 02142 USA;reich@genetics.med.harvard.edu myers@stats.ox.ac.uk
    1. Year: 2011
    2. Date: Aug
  2. Journal: Nature
    1. 476
    2. 7359
    3. Pages: 170-U67
  4. Type of Article: Article
  5. ISSN: 0028-0836
  1. Abstract:

    Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9(P value <10(-245)). We identify a 17-base-pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of PRDM9 alleles common in West Africans and rare in Europeans. Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution.

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External Sources

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  2. DOI: 10.1038/nature10336
  3. View record in Web of Science®
  4. WOS: 000293731900028

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  1. Fiscal Year: FY2010-2011
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