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Inflammatory large bowel disease in immunodeficient rats naturally and experimentally infected with Helicobacter bilis

  1. Author:
    Haines, D. C.
    Gorelick, P. L.
    Battles, J. K.
    Pike, K. M.
    Anderson, R. J.
    Fox, J. G.
    Taylor, N. S.
    Shen, Z.
    Dewhirst, F. E.
    Anver, M. R.
    Ward, J. M.

  2. Author Address

    Ward JM NCI, Vet & Tumor Pathol Sect, Anim Sci Branch, Off Lab Anim Resources,Div Basic Sci,FCRDC Fairview 201,POB B Frederick, MD 21702 USA NCI, Vet & Tumor Pathol Sect, Anim Sci Branch, Off Lab Anim Resources,Div Basic Sci,FCRDC Frederick, MD 21702 USA NCI, Pathol Histotechnol Lab, Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA NCI, Lab Anim Sci Program, Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA NCI, Lab Cell & Mol Struct, Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA MIT, Div Comparat Med Cambridge, MA 02139 USA Forsyth Dent Ctr, Dept Mol Genet Boston, MA 02115 USA
    1. Year: 1998
  2. Journal: Veterinary Pathology
    1. 35
    2. 3
    3. Pages: 202-208
  4. Type of Article: Article
  1. Abstract:

    Proliferative and ulcerative typhlitis, colitis, and proctitis were found incidentally in a breeding colony of male athymic nude (Cr:NIH-rnu) rats. Within the crypts of the large intestine, modified Steiner's silver stain revealed spiral organisms that were identified by culture, polymerase chain reaction, and sequencing to be Helicobacter bills. The large bowel disease was reproduced in H. bilis-free male athymic nude rats that were injected intraperitoneally with a culture of H. bilis from the affected colony. The organism was isolated from the feces and cecum of the experimentally infected rats. H. bilis should be considered a potential pathogen in immunocompromised rats. The infection in immunocompromised rats may serve as an animal model for inflammatory large bowel disease. [References: 46]

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