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Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study

  1. Author:
    Simmons, G.
    Glynn, S. A.
    Komaroff, A. L.
    Mikovits, J. A.
    Tobler, L. H.
    Hackett, J.
    Tang, N.
    Switzer, W. M.
    Heneine, W.
    Hewlett, I. K.
    Zhao, J. Q.
    Lo, S. C.
    Alter, H. J.
    Linnen, J. M.
    Gao, K.
    Coffin, J. M.
    Kearney, M. F.
    Ruscetti, F. W.
    Pfost, M. A.
    Bethel, J.
    Kleinman, S.
    Holmberg, J. A.
    Busch, M. P.
    Blood, X. S. R. W. G.

  2. Author Address

    [Simmons, G; Tobler, LH; Busch, MP] Blood Syst Res Inst, San Francisco, CA 94118 USA. [Simmons, G; Tobler, LH; Busch, MP] Univ Calif San Francisco, San Francisco, CA 94118 USA. [Glynn, SA] NHLBI, Transfus Med & Cellular Therapeut Branch, NIH, Bethesda, MD 20892 USA. [Komaroff, AL] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Komaroff, AL] Brigham & Womens Hosp, Boston, MA 02115 USA. [Mikovits, JA; Pfost, MA] Univ Nevada, Whittemore Peterson Inst, Reno, NV 89557 USA. [Hackett, J; Tang, N] Abbott Labs, Abbott Pk, IL 60064 USA. [Switzer, WM; Heneine, W] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Hewlett, IK; Zhao, JQ] US FDA, Off Blood Res, Rockville, MD 20852 USA. [Lo, SC] US FDA, Off Cellular Tissue & Gene Therapies Review, Bethesda, MD 20892 USA. [Alter, HJ] NIH, Dept Transfus Med, Bethesda, MD 20892 USA. [Linnen, JM; Gao, K] Gen Probe, San Diego, CA 92121 USA. [Coffin, JM] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA. [Kearney, MF; Ruscetti, FW] NCI, Frederick, MD 21702 USA. [Bethel, J] WESTAT Corp, Rockville, MD 20850 USA. [Kleinman, S] Univ British Columbia, Dept Pathol, Victoria, BC V9A4W4, Canada. [Holmberg, JA] US Dept HHS, Rockville, MD 20852 USA.;Busch, MP (reprint author), Blood Syst Res Inst, San Francisco, CA 94118 USA;mbusch@bloodsystems.org
    1. Year: 2011
    2. Date: Nov
  2. Journal: Science
    1. 334
    2. 6057
    3. Pages: 814-817
  4. Type of Article: Article
  5. ISSN: 0036-8075
  1. Abstract:

    Murine leukemia viruses (MLVs), including xenotropic-MLV-related virus (XMRV), have been controversially linked to chronic fatigue syndrome (CFS). To explore this issue in greater depth, we compiled coded replicate samples of blood from 15 subjects previously reported to be XMRV/MLV-positive (14 with CFS) and from 15 healthy donors previously determined to be negative for the viruses. These samples were distributed in a blinded fashion to nine laboratories, which performed assays designed to detect XMRV/MLV nucleic acid, virus replication, and antibody. Only two laboratories reported evidence of XMRV/MLVs; however, replicate sample results showed disagreement, and reactivity was similar among CFS subjects and negative controls. These results indicate that current assays do not reproducibly detect XMRV/MLV in blood samples and that blood donor screening is not warranted.

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External Sources

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  2. DOI: 10.1126/science.1213841
  3. View record in Web of Science®
  4. WOS: 000296849600049

Library Notes

  1. Fiscal Year: FY2011-2012
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