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Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control study

  1. Author:
    Benavente, Y.
    Mbisa, G.
    Labo, N.
    Casabonne, D.
    Becker, N.
    Maynadie, M.
    Foretova, L.
    Cocco, P. L.
    Nieters, A.
    Staines, A.
    Bofetta, P.
    Brennan, P.
    Whitby, D.
    de Sanjose, S.

  2. Author Address

    [Benavente, Y.; Casabonne, D.; de Sanjose, S.] IDIBELL, Unit Infect & Canc UNIC, Canc Epidemiol Res Programme, Inst Catala Oncol, Barcelona 08908, Spain. [Benavente, Y.; Casabonne, D.; de Sanjose, S.] CIBERESP, Sao Paulo, Brazil. [Mbisa, G.] NCI, Viral Technol Lab, Adv Technol Program, SAIC Frederick Inc, Ft Detrick, MD 21702 USA. [Labo, N.; Whitby, D.] NCI, Viral Oncol Sect, AIDS & Canc Virus Program, SAIC Frederick Inc, Frederick, MD 21702 USA. [Becker, N.] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany. [Maynadie, M.] Univ Burgundy, Registre Hemopathies Malignes Cote Or, EA 4184, Dijon, France. [Foretova, L.] Masaryk Mem Canc Inst, Brno, Czech Republic. [Cocco, P. L.] Univ Cagliari, Dept Publ Hlth, Occupat Hlth Sect, Cagliari, Italy. [Nieters, A.] Univ Med Ctr Freiburg, Dept Mol Epidemiol, Ctr Chron Immunodeficiency, Freiburg, Germany. [Nieters, A.] German Canc Res Ctr, Dept Mol Tumour Epidemiol, D-69120 Heidelberg, Germany. [Staines, A.] Publ Hlth Univ Coll, Dublin, Ireland. [Bofetta, P.] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA. [Bofetta, P.] Int Prevent Res Inst, Lyon, France. [Brennan, P.] Int Prevent Res Inst, IARC, F-69006 Lyon, France. [Maynadie, M.] Biol Hematol Unit, Dijon, France. [Maynadie, M.] Univ Hosp Dijon, CRB Ferdinand Cabanne, Dijon, France.;de Sanjose, S (reprint author), IDIBELL, Unit Infect & Canc UNIC, Canc Epidemiol Res Programme, Inst Catala Oncol, Gran Via Km 199-203, Barcelona 08908, Spain;s.sanjose@iconcologia.net
    1. Year: 2011
    2. Date: Nov
  2. Journal: British Journal of Cancer
    1. 105
    2. 11
    3. Pages: 1768-1771
  4. Type of Article: Article
  5. ISSN: 0007-0920
  1. Abstract:

    BACKGROUND: Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease. METHODS: Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries. RESULTS: Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases (P>0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR) = 4.11, 95% confidence interval (CI) 1.57-10.83) and multiple myeloma (OR = 0.31, 95% CI = 0.11-0.85). CONCLUSION: The KSHV is unlikely to contribute importantly to lymphomagenesis among immunocompetent subjects. However, the observed association with SMZL may underline a chronic antigen mechanism in its aetiology. British Journal of Cancer (2011) 105, 1768-1771. doi:10.1038/bjc.2011.392 www.bjcancer.com

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External Sources

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  2. DOI: 10.1038/bjc.2011.392
  3. View record in Web of Science®
  4. WOS: 000297687600021

Library Notes

  1. Fiscal Year: FY2011-2012
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