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XMRV and prostate cancer-a 'final' perspective

  1. Author:
    Sfanos, K. S.
    Aloia, A. L.
    De Marzo, A. M.
    Rein, A.

  2. Author Address

    [Sfanos, Karen S.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21231 USA. [Aloia, Amanda L.; Rein, Alan] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA. [De Marzo, Angelo M.] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA. [De Marzo, Angelo M.] Johns Hopkins Univ, Sch Med, Brady Urol Res Inst, Baltimore, MD 21231 USA.;Sfanos, KS (reprint author), Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21231 USA;ksfanos@jhmi.edu
    1. Year: 2012
    2. Date: Feb
  2. Journal: Nature Reviews Urology
    1. 9
    2. 2
    3. Pages: 111-118
  4. Type of Article: Article
  5. ISSN: 1759-4812
  1. Abstract:

    XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft. These new findings strongly imply that XMRV does not circulate in humans, but is only present in the laboratory. Thus, there is no reason to believe that it has any role in the etiology of prostate cancer or other diseases.

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  2. DOI: 10.1038/nrurol.2011.225
  3. View record in Web of Science®
  4. WOS: 000300416500010

Library Notes

  1. Fiscal Year: FY2011-2012
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