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Hiv Infection - How Effective Is Drug Combination Treatment

  1. Author:
    Grossman, Z.
    Feinberg, M.
    Kuznetsov, V.
    Dimitrov, D.
    Paul, W.

  2. Author Address

    Grossman Z NIH OFF AIDS RES BETHESDA, MD 20892 USA NIH LAB EXPT & COMPUTAT BIOL FREDERICK, MD 21702 USA TEL AVIV UNIV SACKLER FAC MED DEPT PHYSIOL & PHARMACOL IL-69978 TEL AVIV ISRAEL
    1. Year: 1998
  2. Journal: Immunology Today
    1. 19
    2. 11
    3. Pages: 528-532
  4. Type of Article: Review
  1. Abstract:

    The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs. [References: 22]

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