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Vitamin E Succinate Induces Fas-Mediated Apoptosis in Estrogen Receptor-Negative Human Breast Cancer Cells

  1. Author:
    Turley, J. M.
    Fu, T.
    Ruscetti, F. W.
    Mikovits, J. A.
    Bertolette, D. C.
    Birchenallroberts, M. C.

  2. Author Address

    Birchenallroberts MC NCI LAB LEUKOCYTE BIOL DIV BASIC SCI BLDG 567 ROOM 276 FREDERICK, MD 21702 USA NCI LAB LEUKOCYTE BIOL DIV BASIC SCI FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR INTRAMURAL RES SUPPORT PROGRAM APPLICAT INT CORP FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Cancer Research
    1. 57
    2. 5
    3. Pages: 881-890
  4. Type of Article: Article
  1. Abstract:

    Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells, VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway, Total protein levels of the Fas receptor (Fas; APO-1/CD-95) and the Fas Ligand (Fas-L) were increased following VES treatment, In addition, VES increased cell surface Fas expression, Fas-neutralizing antibodies and Fas-L antisense oligonucleotides blocked VES-induced apoptosis, The presence of Fas-L antisense oligonucleotides also completely blocked the VES-mediated increase in Fas-L protein expression. These data indicate a role for Fas signaling in VES-mediated apoptotic cell death of human breast cancer cells. These findings also suggest that VES may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are refractory to antiestrogen therapy. [References: 61]

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