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Antireplicative and Anticytopathic Activities of Prostratin, a Non-Tumor-Promoting Phorbol Ester, Against Human Immunodeficiency Virus (Hiv)

  1. Author:
    Gulakowski, R. J.
    McMahon, J. B.
    Buckheit, R. W.
    Gustafson, K. R.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI FREDERICK CANC RES & DEV CTR LDDRD DEV THERAPEUT PROGRAM DIV CANC TREATMENT DIAG & CTRS FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR LDDRD DEV THERAPEUT PROGRAM DIV CANC TREATMENT DIAG & CTRS FREDERICK, MD 21702 USA FREDERICK RES CTR SO RES INST VIROL RES DIV FREDERICK, MD 21701 USA
    1. Year: 1997
  2. Journal: Antiviral Research
    1. 33
    2. 2
    3. Pages: 87-97
  4. Type of Article: Article
  1. Abstract:

    Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV) 3-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both Viral strain and host cell type. Prostratin activated Viral expression in two latently-infected cell lines, but had little or no effect on chronically-infected cell lines. Prostratin caused a dose-dependent, but reversible, decrease in CD4 expression in the CEM-SS and MT-2 cell lines. This down-regulation of CD4 was inhibited in a dose-dependent manner by the protein kinase C (PKC) antagonist, staurosporine. In addition, the cytoprotective and cytostatic effects of prostratin in CEM-SS cells acutely infected with HIV-1(RF) were reversed by bryostatin-1, a PKC agonist. Prostratin had no effect on reverse transcriptase or HIV-1 protease, nor did it inhibit the binding of gp120 to CD4. We conclude that prostratin inhibits HIV cytopathicity and replication through mechanism(s) involving PKC enzyme(s). Copyright (C) 1997 Elsevier Science B.V. [References: 22]

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