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Analysis of amino insertion mutations in the fingers subdomain of HIV-1 reverse transcriptase

  1. Author:
    Boyer, P. L.
    Lisziewicz, J.
    Lori, F.
    Hughes, S. H.

  2. Author Address

    Hughes SH NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program POB B Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA Georgetown Univ, Res Inst Genet & Human Therapy Washington, DC 20007 USA Policlin San Matteo, IRCCS, RIGHT I-27100 Pavia Italy
    1. Year: 1999
  2. Journal: Journal of Molecular Biology
    1. 286
    2. 4
    3. Pages: 995-1008
  4. Type of Article: Article
  1. Abstract:

    In response to dideoxy inosine/hydroxyurea dual therapy, HIV-1 (human immunodeficiency virus type-1) variants were isolated that had a small amino acid insertion and flanking amino acid substitutions in the fingers subdomain of HIV-1. We have analyzed the reverse transcriptase variants for their effects on HIV-1 reverse transcriptase activity. The data suggests that the inserted amino acid residues are responsible for low-level resistance to the nucleoside analog ddITP, while the role of the flanking amino acid substitutions is to compensate for the deleterious effects of the insertion. [References: 26]

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