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Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture

  1. Author:
    Kennelly, E. J.
    Flynn, T. J.
    Mazzola, E. P.
    Roach, J. A.
    McCloud, T. G.
    Danford, D. E.
    Betz, J. M.

  2. Author Address

    Kennelly EJ CUNY Herbert H Lehman Coll, Dept Biol Sci 250 Bedford Pk Blvd W Bronx, NY 10468 USA US FDA, Ctr Food Safety & Appl Nutr Washington, DC 20204 USA Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Journal of Natural Products
    1. 62
    2. 10
    3. Pages: 1385-1389
  4. Type of Article: Article
  1. Abstract:

    The novel alkaloid thalictroidine (1), as well as the known alkaloids taspine (2), magnoflorine (3), anagyrine (4), baptifoline (5), 5,6-dehydro-alpha-isolupanine (6), alpha-isolupanine (7), lupanine (8), N-methylcytisine (9), and sparteine (10), were identified from an extract of Caulophyllum thalictroides rhizomes. N-Methylcytisine exhibited teratogenic activity in the rat embryo culture (REC), an in vitro method to detect potential teratogens. The structure of 1 was elucidated using various spectroscopic methods, primarily by NMR techniques. Thalictroidine, anagyrine, and a-isolupanine were not teratogenic in the REC at tested concentrations. Taspine (2) showed high embryotoxicity, but no teratogenic activity, in the REC. [References: 24]

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