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Thyroid-specific enhancer-binding protein thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia

  1. Author:
    Kimura, S.
    Ward, J. M.
    Minoo, P.

  2. Author Address

    Kimura S NCI, Lab Metab, NIH Bldg 37,Room 3E-24,9000 Rockville Pike Bethesda, MD 20892 USA NCI, Lab Metab, NIH Bethesda, MD 20892 USA NCI, Vet & Tumor Pathol Sect Frederick, MD 21702 USA Univ So Calif, Sch Med, Dept Pediat Los Angeles, CA 90033 USA
    1. Year: 1999
  2. Journal: Biochimie
    1. 81
    2. 4
    3. Pages: 321-327
  4. Type of Article: Article
  1. Abstract:

    Targeted disruption of the homeobox gene T/ebp (Ttf1) in mice results in ablation of the thyroid and pituitary, and severe deformities in development of the lung and hypothalamus. T/ebp is expressed in the thyroid, lung, and ventral forebrain during normal embryogenesis. Examination of thyroid development in T/ebp homozygous null mutant embryos revealed that the thyroid rudiment is initially formed but is eliminated through apoptosis. Absence of T/EBP expression in the lung primordium does not activate apoptosis since a lung tissue, albeit dysmorphic, is nevertheless formed in T/ebp(-/-) embryos. These results demonstrate that T/EBP is not required for the initial specification of thyroid or lung primordia, but is absolutely essential for the development and morphogenesis of these organs. (C) Societe francaise de biochimie et biologie moleculaire / Elsevier, Paris. [References: 53]

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