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Synthesis and biological activity of a novel C4-C6 bridged paclitaxel analog

  1. Author:
    Yuan, H. Q.
    Kingston, D. G. I.
    Sackett, D. L.
    Hamel, E.

  2. Author Address

    Kingston DGI Virginia Polytech Inst & State Univ, Dept Chem Blacksburg, VA 24061 USA Virginia Polytech Inst & State Univ, Dept Chem Blacksburg, VA 24061 USA NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Tetrahedron
    1. 55
    2. 32
    3. Pages: 9707-9716
  4. Type of Article: Article
  1. Abstract:

    The novel paclitaxel analog 15 with a bridge between the C-4 and C-6 positions was synthesized and was found to be less active than paclitaxel in in vitro tubulin assembly and cytotoxicity assays. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 25]

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