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EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus

  1. Author:
    Wang, Xiaolei
    Sun, Jian
    Li, Chaocui
    Mao, Bingyu

  2. Author Address

    Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650203, Peoples R China.NCI, Lab Cell & Dev Signaling, NIH, Frederick, MD 21702 USA.
    1. Year: 2016
    2. Date: Oct 28
  2. Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  3. ACADEMIC PRESS INC ELSEVIER SCIENCE,
    1. 479
    2. 4
    3. Pages: 759-765
  5. Type of Article: Article
  6. ISSN: 0006-291X
  1. Abstract:

    Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain throughout neurulation in Xenopus embryos. Knockdown of EphA7 by specific morpholino oligonucleotide (MO) disrupted cranial neural tube closure and disturbed apical constriction of hindbrain neuroepithelial cells, indicating weakened cell surface tension. In neural plate explants, EphA7 knockdown inhibited apical filamentous actin (F-actin) accumulation. We further showed that EphA7 is involved in the phosphorylation and activation of focal adhesion kinase (FAK) in vivo and in vitro, a key regulator of actin assembly. Our findings reveal that EphA7 functions as a critical regulator of apical constriction of hindbrain neuroepithelial cells. (C) 2016 Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.bbrc.2016.09.138
  3. View record in Web of Science®
  4. WOS: 000387200300025

Library Notes

  1. Fiscal Year: FY2016-2017
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