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Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins

  1. Author:
    Xia, Li
    Schrump, David S.
    Gildersleeve, Jeffrey

  2. Author Address

    NCI, Biol Chem Lab, Ctr Canc Res, NIH, 376 Boyles St,Room 208, Frederick, MD 21702 USA.NCI, Thorac Oncol Sect, Thorac & GI Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
    1. Year: 2016
    2. Date: Dec 22
  2. Journal: Cell Chemical Biology
  3. CELL PRESS,
    1. 23
    2. 12
    3. Pages: 1515-1525
  5. Type of Article: Article
  6. ISSN: 2451-9448
  1. Abstract:

    Whole-cell cancer vaccines are a promising strategy for treating cancer, but the characteristics of a favorable immune response are not fully understood. New insights could enable development of better vaccines, discovery of new antigens, and identification of biomarkers of efficacy. Using glyco-antigen microarrays, we demonstrate that GVAX Pancreas (a granulocyte macrophage colony-stimulating factor- modified whole-cell tumor vaccine) induces large immunoglobulin G and immunoglobulinMresponses to many antigens, including tumor-associated carbohydrates, blood group antigens, alpha-Gal, and bovine fetuin. Antibody responses to alpha-Gal, a glycan found in fetal bovine serum (FBS) used to produce the vaccine, correlated inversely with overall survival and appear to compete with productive responses to the vaccine. H1299 lysate vaccine, produced with FBS, also induced responses to alpha-Gal and fetuin but not K562-GM, which is produced in serum-free medium. Our results provide new potential biomarkers to evaluate productive/unproductive immune responses and suggest that removal/reduction of FBS could improve the efficacy of whole-cell vaccines.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.chembiol.2016.10.012
  3. PMID: 27889407
  4. PMCID: PMC5182097
  5. View record in Web of Science®
  6. WOS: 000392842300012

Library Notes

  1. Fiscal Year: FY2016-2017
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