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Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping

  1. Author:
    Murphy, W. J.
    Sun, S.
    Chen, Z. Q.
    Pecon-Slattery, J.
    O'Brien, S. J.

  2. Author Address

    Murphy WJ NCI, Frederick Canc Res & Dev Ctr, Lab Genom Divers Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Genom Divers Frederick, MD 21702 USA George Mason Univ, Grad Program Biol Fairfax, VA 22030 USA NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, Sci Applicat Int Corp Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Genome Research
    1. 9
    2. 12
    3. Pages: 1223-1230
  4. Type of Article: Article
  1. Abstract:

    A radiation hybrid [RH]-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY-DBY-UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production. [References: 42]

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