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Performance of microscopic observation drug susceptibility for the rapid diagnosis of tuberculosis and detection of drug resistance in Bamako, Mali

  1. Author:
    Sanogo, M.
    Kone, B.
    Diarra, B.
    Maiga, M.
    Baya, B.
    Somboro, A. M.
    Sarro, Y. S.
    Togo, A. C. G.
    Dembele, B. P. P.
    Goita, D.
    Kone, A.
    M'Baye, O.
    Coulibaly, N.
    Diabate, S.
    Traore, B.
    Diallo, M. H.
    Coulibaly, Y. I.
    Saleeb, P.
    Belson, M.
    Orsega, S.
    Siddiqui, S.
    Polis, M. A.
    Dao, S.
    Murphy, R. L.
    Diallo, S.

  2. Author Address

    USTTB, Univ Clin Res Ctr, SEREFO Labs, Bamako, Mali.Inst Trop Med, Biomed Dept, Antwerp, Belgium.Leidos Biomed Res Inc, Clin Res Directorate, Clin Monitoring Res Program, NCI Campus Frederick, Frederick, MD USA.USTTB, Filariasis Unit, MRTC, Bamako, Mali.Univ Maryland, Sch Med, Baltimore, MD 21201 USA.NIAID, Div Clin Res, 9000 Rockville Pike, Bethesda, MD 20892 USA.Northwestern Univ, Div Infect Dis, Chicago, IL 60611 USA.
    1. Year: 2017
    2. Date: Jun
  2. Journal: CLINICAL MICROBIOLOGY AND INFECTION
  3. ELSEVIER SCI LTD,
    1. 23
    2. 6
  5. Type of Article: Article
  6. ISSN: 1198-743X
  1. Abstract:

    Objectives: In Mali early detection and treatment of multidrug-resistant tuberculosis MDR-TB) are still challenging due to the cost, time and/or complexity associated with regular tests. Microscopic Observation Drug Susceptibility MODS) is a low-cost assay validated by WHO in 2010. It is a liquid-culture-based assay to detect the 'cording' characteristic of Mycobacterium tuberculosis complex and to assess susceptibility to both isoniazid and rifampicin defining multidrug-resistant tuberculosis MDR-TB). In this study we aimed to evaluate the performance of MODS as diagnostic tool compared with a validated methoddMycobacteria Growth Indicator Tube/Antimicrobial Susceptibility Testing/Streptomycin, Isoniazid, Rifampicin and Ethambutol MGIT/AST/SIRE).

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cmi.2017.01.004
  3. View record in Web of Science®
  4. WOS: 000405331900017

Library Notes

  1. Fiscal Year: FY2016-2017
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