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Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides

  1. Author:
    Zhao, Xue Zhi
    Hymel, David
    Burke, Terrence

  2. Author Address

    NCI, Biol Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA.
    1. Year: 2017
    2. Date: OCT 1
  2. Journal: BIOORGANIC & MEDICINAL CHEMISTRY
  3. PERGAMON-ELSEVIER SCIENCE LTD,
    1. 25
    2. 19 Special Issue: SI
    3. Pages: 5041-5049
  5. Type of Article: Article
  6. ISSN: 0968-0896
  1. Abstract:

    An important goal in the development of polo-like kinase 1 (Plk1) polo-box domain (PBD) binding inhibitors is selectivity for Plk1 relative to Plk2 and Plk3. In our current work we show that Plk1 PBD selectivity can be significantly enhanced by modulating interactions within a previously discovered "cryptic pocket" and a more recently identified proximal "auxiliary pocket." Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmc.2017.02.063
  3. View record in Web of Science®
  4. WOS: 000413401200003

Library Notes

  1. Fiscal Year: FY2017-2018
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