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Pregnancy on vandetanib in metastatic medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2B

  1. Author:
    Thomas, Nicholas
    Glod, John
    Derse-Anthony, Claudia
    Baple, Emma L
    Obsborne, Nigel
    Sturley, Rachel
    Vaidya, Bijay
    Newbold, Kate
    Brooke, Antonia

  2. Author Address

    Department of Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Paediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA., Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21702., Department of Genetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., University of Exeter Medical School, Exeter, UK., Department of Neonatology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Department of Obstetrics, Royal Devon and Exeter NHS Foundation Trust Exeter, UK., Head and Neck Oncology Unit, the Royal Marsden NHS Foundation Trust, Sutton, UK.,
    1. Year: 2018
    2. Date: May
    3. Epub Date: 2018 02 19
  2. Journal: Clinical endocrinology
    1. 5
    2. Pages: 754-756
  4. Type of Article: Article
  5. ISSN: 0300-0664
  1. Abstract:

    Vandetanib is a tyrosine kinase inhibitor (TKI) used in the treatment of medullary thyroid carcinoma occurring in >95% of patients with multiple endocrine neoplasia type 2b (MEN 2b). Pregnancy in women with MEN 2b on vandetanib is previously unreported and has multiple potential implications for both the mother and developing fetus [1]. We describe the case of a 22 year old woman with a background of MEN 2b who was first diagnosed aged 6 presenting with marfanoid habitus, and oral mucosal neuromas. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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External Sources

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  2. DOI: 10.1111/cen.13577
  3. PMID: 29457255
  4. View record in Web of Science®
  5. WOS: 000430170300020

Library Notes

  1. Fiscal Year: FY2017-2018
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